Latex Immunoturbidimetric Assay for Soluble Fibrin Complex

Hamano, Akiei; Umeda, Masaki; Ueno, Yuta; Tanaka, Seiji; Mimuro, Jun; Sakata, Yoichi

doi:10.1373/clinchem.2004.040360

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…A high level of SF in clinical plasma samples has been recognized to be an indicator of ongoing intravascular coagulation processes (Hamano et al 2005). SF expresses an acute intravascular fibrin formation as well because SF is one of circulating materials growing fibrin clots.…”

Section: Discussionmentioning

confidence: 99%

Association between venous thromboembolism and plasma levels of both soluble fibrin and plasminogen-activator inhibitor 1 in 170 patients undergoing total hip arthroplasty

et al. 2012

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Background and purpose Markers of coagulation and fibrinolysis, such as soluble fibrin (SF), D-dimer, and plasminogen activator inhibitor 1 (PAI-1), have been developed in order to determine thrombotic tendency. We investigated whether these markers could be used to diagnose venous thromboembolism (VTE) in the early phase after primary total hip arthroplasty (THA).Methods This prospective study involved 2 groups: an intermittent pneumatic compression (IPC) group (67 patients who underwent IPC only as prophylaxis for VTE) and a fondaparinux (FPX) group (103 patients who received IPC and FPX postoperatively). Plasma levels of SF and PAI-1 were measured on postoperative day 1. To diagnose postoperative VTE, multi-detector row computed tomography (MDCT) and duplex ultrasonography (US) were performed on postoperative day 7.Results VTE was detected postoperatively in 17 cases in the IPC group (25%) and in 8 cases in the FPX group (6%). In the IPC group, plasma levels of SF and PAI-1 were higher in patients with VTE (p < 0.01) than in those without VTE. On the other hand, in the FPX group there were no differences in the levels of SF or PAI-1 measured before administration of FPX on postoperative day 1. The diagnostic criterion of an increase in SF or PAI-1 above the cutoff level (19.8 µg/mL and 53.5 ng/mL, respectively) provided a sensitivity of 100% and a specificity of 67% in the IPC group. In addition, when this criterion was applied to FPX patients, 7 of the 8 patients with VTE met the criterion, and there was a negative agreement rate of 48/49.Interpretation Screening using the cutoff levels of SF and PAI-1 may be useful and shows high sensitivity in predicting postoperative VTE in the early phase after THA.

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Section: Discussionmentioning

confidence: 99%

Association between venous thromboembolism and plasma levels of both soluble fibrin and plasminogen-activator inhibitor 1 in 170 patients undergoing total hip arthroplasty

et al. 2012

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“…SF reflects acute intravascular fibrin formation as well because SF is one of the circulating materials contributing to fibrin clots [30]. PAI-1 is also produced at the site of inflammation following tissue injury [18,23].…”

Section: Fibrinolysis and Thrombolysis 170mentioning

confidence: 99%

Coagulation and Fibrinolysis Markers and Their Use for the Prediction of High Risk Patients with Venous Thromboembolism Following Total Hip Arthroplasty

Inaba¹,

Yukizawa²,

Saito³

2014

Fibrinolysis and Thrombolysis

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“…When a cross-linking reaction is induced by activated factor XIII (XIIIa), FMC or SF is converted to insoluble fibrin and forms thrombus (Folk and Finlayson 1977). Therefore, FMC is well known as a good indicator of thrombogenic conditions (Misaki et al 2008), such as congenital thrombotic tendency or disseminated intravascular coagulation (DIC) (Siegal et al 1978;Okajima et al 1996;Wada et al 1996;Hamano et al 2005).…”

mentioning

confidence: 99%

Plasma Soluble Fibrin Monomer Complex as a Marker of Coronary Thrombotic Events in Patients with Acute Myocardial Infarction

Ieko

Naito

Yoshida

et al. 2009

Tohoku J. Exp. Med.

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Latex Immunoturbidimetric Assay for Soluble Fibrin Complex

Abstract: In terms of linearity, precision, and sensitivity, the LIA, performed on a Hitachi 911 automated analyzer, may be useful for measurement of SFC in plasma.

Cited by 21 publications

References 17 publications

Association between venous thromboembolism and plasma levels of both soluble fibrin and plasminogen-activator inhibitor 1 in 170 patients undergoing total hip arthroplasty

Association between venous thromboembolism and plasma levels of both soluble fibrin and plasminogen-activator inhibitor 1 in 170 patients undergoing total hip arthroplasty

Coagulation and Fibrinolysis Markers and Their Use for the Prediction of High Risk Patients with Venous Thromboembolism Following Total Hip Arthroplasty

Plasma Soluble Fibrin Monomer Complex as a Marker of Coronary Thrombotic Events in Patients with Acute Myocardial Infarction

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