Latex from Tabernaemontana catharinensis (A. DC)—Apocynaceae: An alternative for the sustainable production of biologically active compounds

Menecucci, Carolina da Silva; Mucellini, Kathiele Luiza; Oliveira, Márcia Machado de; Higashi, Bruna; Almeida, Rafaela Takako Ribeiro de; Porto, Carla; Pilau, Eduardo Jorge; Gonçalves, José Eduardo; Gonçalves, Regina Aparecida Correia; Oliveira, Arildo José Braz de

doi:10.1016/j.indcrop.2018.11.036

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…The biochemical composition of the crude latex of T. catharinensis presented 52.5% protein, 21.2% free amino acids, and potent proteolytic activity, as described by da Silva Menecucci et al (2019). The analysis also revealed that crude latex contains 26.3% of total sugars.…”

Section: Chemical Characterisation Of the Crude Latex Of Tabernaemontana Catharinensismentioning

confidence: 53%

“…The precipitate was discarded, and the resulting supernatant was lyophilised and maintained at -20 °C until assays were performed. The plot comprising almost all compounds of watersoluble latex was named latex of T. catharinensis (A. DC) (Mousinho et al, 2011;da Silva Menecucci et al, 2019).…”

Section: Bacterial Strains and Culture Mediamentioning

confidence: 99%

“…It presents biological action, such as antioxidant, antiviral, antimicrobial, trypanocidal and antileishmanial (Janning et al, 2011;da Silva Brum et al, 2016;Soares et al, 2007). This plant has lactiferous cells that secrete latex, an aqueous emulsion with various chemical substances and varied bioactive compounds, such as polyphenols, flavonoids, sugars, amino acids, n-alkanes, alkaloids and proteins that are secreted in response to tissue damage in the plant (Boligon et al, 2015;Dussourd, 2017;Lewinsohn, 1991;da Silva Menecucci et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition of T. catharinensis latex used in the current study presents 52.5% protein, 21.2% free amino acids, and a strong proteolytic activity in addition to other properties as described by Menecucci et al, 2019. This research aimed to evaluate the antimicrobial activity of the crude latex of T. catharinensis against microbial species of the genus Alicyclobacillus.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of crude extract of Tabernaemontana catharinensis latex (A. DC) against Alicyclobacillus spp.

Richard

Anjos

Mucellini

et al. 2021

RSD

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Alicyclobacillus spp. is composed of Gram-positive, aerobic, thermoacidophilic, endospore-forming bacteria that cause food and beverage spoilage. The presence of Alicyclobacillus spp. may result in the production of guaiacol, which leads to sensory changes in the odour and taste of citrus juices and acidic foods. Tabernaemontana catharinensis (A. DC) is a plant belonging to the family Apocynaceae that produces milky latex with several biological activities described as antioxidant, antiviral, antimicrobial, trypanocidal and anti-leishmanicidal. Therefore, this study aims to evaluate the antimicrobial activity of the crude latex of T. catharinensis (A. DC) against microorganisms of the genus Alicyclobacillus spp. The minimum inhibitory concentration of latex was 7.81 μg/ml for the five Alicyclobacillus species analysed. The minimum bactericidal concentration for the species Alicyclobacillus acidoterrestris 0244T, A. hesperidum 0298T, A. acidiphilus 0247T and A. cycloheptanicus 0297T was 250 μg/ml. Cytotoxicity analysis demonstrated that latex was toxic to Vero cells at concentrations greater than 84.67 μg/ml. Scanning electron microscopy revealed changes in the cell wall of A. acidoterrestris 0244T present in orange juice when treated with crude latex. The results obtained suggest that the crude latex of T. catharinensis (A. DC) displays an antimicrobial effect against Alicyclobacillus, with potential for application in the food industry.

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Section: Chemical Characterisation Of the Crude Latex Of Tabernaemontana Catharinensismentioning

confidence: 53%

Section: Bacterial Strains and Culture Mediamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of crude extract of Tabernaemontana catharinensis latex (A. DC) against Alicyclobacillus spp.

Richard

Anjos

Mucellini

et al. 2021

RSD

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“…In the year 2000, it was reported that the compound 12-methoxy-4-methyl voachalotine isolated from the roots of Tabernaemontana catharinensis was able to neutralize the lethality and myotoxicity induced by Crotalus durissus venom [116]. Lately, it was found that the latex of T. catharinensis has several other indole alkaloids that are potential candidates for screening against snake phospholipases and metalloproteases [117].…”

Section: Natural Products In the Development Of Antivenom Agentsmentioning

confidence: 99%

Perspective on the Therapeutics of Anti-Snake Venom

Gómez-Betancur

Gogineni²,

Salazar-Ospina

et al. 2019

Molecules

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Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches to envenomation is required to palliate the morbidity and mortality effects of this NTD. The specific therapeutic treatment for this NTD uses snake antivenom immunoglobulins. Unfortunately, access to these vital drugs is limited, principally due to their cost. Different ethnic groups in the affected regions have achieved notable success in treatment for centuries using natural sources, especially plants, to mitigate the effects of snake envenomation. The ethnopharmacological approach is essential to identify the potential metabolites or derivatives needed to treat this important NTD. Here, the authors describe specific therapeutic snakebite envenomation treatments and conduct a review on different strategies to identify the potential agents that can mitigate the effects of the venoms. The study also covers an increased number of literature reports on the ability of natural sources, particularly plants, to treat snakebites, along with their mechanisms, drawbacks and future perspectives.

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Chemistry, Biological Activities, and Uses of Latex from Selected Species of Apocynaceae

Naidoo¹,

Munsamy²,

Naidoo³

et al. 2021

Reference Series in Phytochemistry

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Latex from Tabernaemontana catharinensis (A. DC)—Apocynaceae: An alternative for the sustainable production of biologically active compounds

Cited by 8 publications

References 33 publications

Antibacterial activity of crude extract of Tabernaemontana catharinensis latex (A. DC) against Alicyclobacillus spp.

Antibacterial activity of crude extract of Tabernaemontana catharinensis latex (A. DC) against Alicyclobacillus spp.

Perspective on the Therapeutics of Anti-Snake Venom

Chemistry, Biological Activities, and Uses of Latex from Selected Species of Apocynaceae

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