Latest Trends in Temperature Sensing by Molecular Probes

Ogle, Meredith M.; McWilliams, Ashleigh D. Smith; Jiang, Bo; Martí, Ángel A.

doi:10.1002/cptc.201900255

Cited by 38 publications

(30 citation statements)

References 66 publications

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“…various FRET biosensors. Temperature control is essential for cell viability, and growing evidence highlights the importance of the temperature gradients that are experienced by metabolically active biological tissues (Chrétien et al, 2018;Ogle et al, 2020;Zhou et al, 2020). Importantly, in breast and colon cancer cells, temperature gradients have been linked to the function of the uncoupling protein UCP1, mitochondrial function and cell oxygenation (Jenkins et al, 2016;Kawashima et al, 2020).…”

Section: Protein Interactionsmentioning

confidence: 99%

Luminescence lifetime imaging of three-dimensional biological objects

Dmitriev

Intes

Barroso

2021

Journal of Cell Science

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A major focus of current biological studies is to fill the knowledge gaps between cell, tissue and organism scales. To this end, a wide array of contemporary optical analytical tools enable multiparameter quantitative imaging of live and fixed cells, three-dimensional (3D) systems, tissues, organs and organisms in the context of their complex spatiotemporal biological and molecular features. In particular, the modalities of luminescence lifetime imaging, comprising fluorescence lifetime imaging (FLI) and phosphorescence lifetime imaging microscopy (PLIM), in synergy with Förster resonance energy transfer (FRET) assays, provide a wealth of information. On the application side, the luminescence lifetime of endogenous molecules inside cells and tissues, overexpressed fluorescent protein fusion biosensor constructs or probes delivered externally provide molecular insights at multiple scales into protein–protein interaction networks, cellular metabolism, dynamics of molecular oxygen and hypoxia, physiologically important ions, and other physical and physiological parameters. Luminescence lifetime imaging offers a unique window into the physiological and structural environment of cells and tissues, enabling a new level of functional and molecular analysis in addition to providing 3D spatially resolved and longitudinal measurements that can range from microscopic to macroscopic scale. We provide an overview of luminescence lifetime imaging and summarize key biological applications from cells and tissues to organisms.

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Section: Protein Interactionsmentioning

confidence: 99%

Luminescence lifetime imaging of three-dimensional biological objects

Dmitriev

Intes

Barroso

2021

Journal of Cell Science

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“…small molecules and organic-inorganic hybrids. [23,32,[39][40][41][42][43][44][45][46][47] The investigation of different antennae is required to develop temperatures ensors with divers opticalp roperties and to create a divers offer for the different application fields. Sensors are typically operative in ad istinct temperature region,n amely cryogenic (up to 100 K), medium (100-300 K), biological/physiological (298-323 K) and the high temperature region (!…”

Section: The Importanceo Fl Anthanidesmentioning

confidence: 99%

Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing

Bussche

Kaczmarek

Speybroeck

et al. 2021

Chemistry A European J

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The market shareo fn oncontact temperature sensors is expending due to fast technological and medical evolutions. In the wide varietyo fn oncontact sensors, lanthanide-based temperature sensors stand out. They benefit from high photostability,r elativelyl ong decay times and high quantum yields. To circumvent their low molar light absorption, the incorporationo falight-harvesting antenna is required. This Review provides an overview of the nitrogenrich antennae in lanthanide-based temperature sensors, emitting in the visible light spectrum, and discusses their temperature sensor ability.T he N-rich ligandsa re incorporated in many different platforms. The investigation of different antennae is required to developt emperature sensors with diverse optical properties andt oc reate ad iverse offer for the multiple application fields. Molecular probes, consisting of small molecules, are first discussed. Furthermore, the thermometerp roperties of ratiometric temperature sensors, based on di-and polynuclear complexes,m etal-organic frameworks, periodic mesoporouso rganosilicas andp orous organicp olymers, are summarized. The antenna mainly determines the application potential of the ratiometric thermometer. It can be observed that molecular probesa re operational in the broad physiological range, metal-organic frameworks are generally very useful in the cryogenic region,p eriodic mesoporous organosilica show temperature dependency in the physiological range, and porous organic polymers are operativei n the cryogenic-to-medium temperature range.

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“…[16][17][18][19][20] However, they can hardly be applied to high-temperature indication or sensing because most organic dyes suffer a significant emission quenching at high temperatures due to thermofacilitated nonradiative decay. [21,22] Hightemperature sensors are essential in many aspects, including damage detection of building materials, surface temperature measurement of aeronautical components and the maximum temperature of base installation after the fire disaster. [23][24][25] Especially, with the fast development of modern industrial technology, it is necessary to monitor the surface temperature of the production equipment or components of manufacturing facilities for ensuring production safety, which gives an early warning signal at heating conditions.…”

Section: Single-sample Ratiometric Organic Films For Naked-eye High-temperature Multi-threshold Indicationmentioning

confidence: 99%

Single‐Sample Ratiometric Organic Films for Naked‐Eye High‐Temperature Multi‐Threshold Indication

Kong

Zhan

Yang

et al. 2021

Advanced Optical Materials

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Threshold temperature sensors are crucial for recording the thermal histories of environments under different scenarios. However, most organic threshold thermometers are not suitable for high‐temperature indication due to significant thermo‐facilitated emission quenching. Here, a series of ratiometric luminescent high‐temperature threshold organic film indicators have been realized by synergetic effects of intramolecular local excited to charge transfer states and disaggregation from excimer to monomer. Varying the polymer matrixes with different glass transition temperatures effectively tunes the threshold sensing temperatures. More importantly, the wide sensing span of the high‐temperature region enables the single‐sample films (in one kind of polymer matrix) to achieve multiple temperature threshold indications, directed only by multiple naked‐eye emission color changes. These drop‐casting organic film thermometers indicate great potential in robust and low‐cost outdoor applications, as well as large‐area and flexible threshold temperature sensing.

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Latest Trends in Temperature Sensing by Molecular Probes

Cited by 38 publications

References 66 publications

Luminescence lifetime imaging of three-dimensional biological objects

Luminescence lifetime imaging of three-dimensional biological objects

Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing

Single‐Sample Ratiometric Organic Films for Naked‐Eye High‐Temperature Multi‐Threshold Indication

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