Latest strategies for rapid and point of care detection of mycotoxins in food: A review

Suo, Zhiguang; Niu, Xingyuan; Wei, Min; Jin, Huali; He, Baoshan

doi:10.1016/j.aca.2023.340888

Cited by 28 publications

(7 citation statements)

References 113 publications

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“…However, the reported side-flow analysis, microfluidic devices, and smartphone-based POCT for mycotoxin detection usually rely on antibodies that are expensive to produce, and the use of animals for this purpose may raise ethical concerns. 158,[160][161][162][163] The introduction of NASAT-based aptasensors into the side-flow analysis and microfluidic system may significantly improve the sensitivity, overcoming the issue of low field detection sensitivity. [164][165][166][167][168] In addition, the use of smartphones to analyze the output signal not only satisfies the portability of the field detection equipment but also ensures the reliability and stability of the result analysis as compared with the naked eye.…”

Section: Author Contributionsmentioning

confidence: 99%

Recent advances in nucleic acid signal amplification-based aptasensors for sensing mycotoxins

Zhang,

Luo,

Cai

et al. 2024

Chem. Commun.

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Section: Author Contributionsmentioning

confidence: 99%

Recent advances in nucleic acid signal amplification-based aptasensors for sensing mycotoxins

Zhang,

Luo,

Cai

et al. 2024

Chem. Commun.

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“…ELISA cannot be used outside the lab. (Suo et al, 2023) and LFAs are restricted to 1D horizontal fluidic flow. However, µPADs create channels through which fluids can flow in multiple directions without the use of additional elements by using patterned surfaces (Kim et al, 2023).…”

Section: Market Demand and Future Prospectsmentioning

confidence: 99%

Evaluation of food μPADs with the new tech perspectives and future prospects

Okutan Arslan,

Trabzon

2023

eFood

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Food microfluidic paper‐based analytical devices (µPADs) are powerful tools to create total analysis systems and have long been demonstrated to be useful for safety and quality applications. Thanks to new technological innovations food µPADs offer exciting new possibilities. This review introduces how µPADs are obtained from chromatography, filter, or office papers and detect analytes from a food sample. We introduce the most current developments in the use of µPADs with an emphasis on paper types, adapted new technologies, and detection limits. Classifications are also made on food µPADs according to applied innovations and adapted novel technologies. In the first section, simple forms of µPADs for the detection of pathogen, mycotoxin, pesticides, and other food components are discussed with technical details. Then, we introduce multisensing approaches for high throughput analysis and a concise summary will be given. In the case of three‐dimensional (3D) µPADs, the use of 3D is discussed and compared to 2D µPADs in terms of its advantageous with the example of a food colorant test device. In the following section, smartphone adoption to µPADs is introduced in detail with eight different assay examples. Centrifugal platform for nickel assay is demonstrated as an enabling approach with shortened assay times by rotational velocity. The potential of user‐friendly hybrid devices is also summarized in the last part. Finally, we present an outlook to underline the opportunities created by smartphone‐based and intelligent µPADs for food safety and quality with real success perspectives

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“…10 The only exception to this comprehensive testing framework is patulin, a mycotoxin produced primarily by Penicillium expansum, a mold that predominantly infects fruits, particularly apples. 11,12 Previous efforts to generate specific and high-affinity antibodies against patulin have not proven effective for use in immunoassay formats commonly employed in immuno-diagnostics, such as enzyme-linked immunosorbent assays (ELISA) and lateral flow immunoassays (LFIA). 13−17 In addition, monoclonal antibodies, which are considered the gold standard among immunoreagents in commercial assays for mycotoxin detection, have not yet been reported for patulin.…”

mentioning

confidence: 99%

“…Consequently, rapid tests for these compounds are marketed by numerous food immunodiagnostic companies . The only exception to this comprehensive testing framework is patulin, a mycotoxin produced primarily by Penicillium expansum, a mold that predominantly infects fruits, particularly apples. , …”

mentioning

confidence: 99%

Harnessing the Intrinsic Chemical Reactivity of the Mycotoxin Patulin for Immunosensing

Duncan,

Agulló,

Mercader

et al. 2024

Anal. Chem.

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Mycotoxins are globally pervasive contaminants that threaten food safety worldwide. Regulatory authorities have established maximum permissible levels for certain mycotoxins, and their presence is routinely monitored throughout the food chain to ensure the provision of healthy food and safe feed for humans and animals. While immunoanalytical methods are essential for mycotoxin screening, monoclonal antibodies for the detection of patulin are notably absent. Moreover, leading immunodiagnostic companies currently do not offer rapid tests for patulin in their product portfolios. This deficiency in mycotoxin testing is primarily due to the electrophilic reactivity of patulin. In this study, we exploit this reactivity to develop an innovative strategy that targets the stable adduct formed by the reaction of patulin with aryl-1,2-dithiolates, rather than analyzing the mycotoxin itself. Based on this previously unknown reaction, we present the first collection of monoclonal antibodies, enabling the long-sought goal of sensitive, simple, and user-friendly immunosensing of patulin.

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Latest strategies for rapid and point of care detection of mycotoxins in food: A review

Cited by 28 publications

References 113 publications

Recent advances in nucleic acid signal amplification-based aptasensors for sensing mycotoxins

Recent advances in nucleic acid signal amplification-based aptasensors for sensing mycotoxins

Evaluation of food μPADs with the new tech perspectives and future prospects

Harnessing the Intrinsic Chemical Reactivity of the Mycotoxin Patulin for Immunosensing

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