Latest on biomaterial-based therapies for topical treatment of psoriasis

Abstract

Psoriasis is an autoimmune inflammatory disease which is fundamentally different from dermatitis. Its treatments include topical medications and systematic drugs depending on different stages of the disease. However, these commonly...

Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis

“…Psoriasis is an inflammatory skin disease mainly mediated by immunity and it affects millions of people around the world [1] , [2] . It is reported that topical therapy, phototherapy, and immunotherapy have been used for the treatment [3] , [4] , [5] . Topical therapy mainly utilizes drugs such as retinoids, vitamin D derivatives to treat psoriasis [6] .…”

Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis

“…Transdermal drug delivery is an effective route for the treatment of skin diseases, because it allows direct targeting of lesions on the skin and reduces the side effects associated with systemic drug delivery (90)(91)(92)(93). However, the skin barrierstratum corneum could greatly impair the bioavailability of transdermal drug delivery.…”

“…unique advantages, microneedles have been widely used as effective transdermal drug delivery tools for the treatment of skin diseases including psoriasis (90,91,94). Du et al developed a microneedle patch made with hyaluronic acid (HA) and encapsulated MTX into the patch, which could effectively penetrate the IMQ-induced mouse epidermis and impair psoriasis-like skin inflammation in mice (95).…”

“…Microneedles is a type of new drug delivery systems developed in recent years, which can significantly improve the permeability and increase the bioavailability of therapeutic agents by piercing the stratum corneum and creating a large number of reversible microchannels in a minimally invasive manner. Due to these unique advantages, microneedles have been widely used as effective transdermal drug delivery tools for the treatment of skin diseases including psoriasis ( 90 , 91 , 94 ). Du et al.…”

Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of Psoriasis: In Vitro Delivery and In Vivo Antipsoriatic Activity Studies

“…Compared with those of healthy skin, psoriatic lesions are thicker and have greater transepidermal water loss, which limit effective transdermal delivery. 20 Another challenge for delivery is the hydrophobic nature of calcipotriol and its low permeation through the stratum corneum . 21 Therefore, developing a new drug delivery system with fewer side effects to improve patient adherence to therapies is highly desirable.…”