Latest models for the discovery and development of rheumatoid arthritis drugs

Szostak, Bartosz; Gorący, Anna; Pala, Bartłomiej; Rosik, Jakub; Ustianowski, Łukasz; Pawlik, Andrzej

doi:10.1080/17460441.2022.2131765

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2024

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“…It is one of the most common autoimmune diseases, affecting up to 2% of the global population [1]. The differentiating factors in RA include gender, with a higher prevalence in women, age, and geographical location [2,3]. Large-scale genome-wide association studies (GWASs) have enabled the detection of specific risk genes associated with proinflammatory cytokines, chemokines, signal transducers, transcriptional activators, and pathways, including over 100 single nucleotide polymorphisms (SNPs) located outside of the human leukocyte antigen (HLA) system [4].…”

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confidence: 99%

The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis

Rosik,

Kulpa,

Szczepanik

et al. 2024

Cells

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Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Inflammation of the synovial fluid propagates the pathological process of angiogenesis. Semaphorins play a crucial role in the context of endothelial cell function, and their pleiotropic nature has various effects on the further development of RA. This narrative review summarises the various roles of semaphorins in the pathology of RA and whether they could play a role in developing novel RA treatment options.

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