Latest Findings in Intellectual and Developmental Disabilities Research

Tan, Üner

doi:10.5772/1236

Cited by 8 publications

(1 citation statement)

References 428 publications

(493 reference statements)

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“…The prevalence of dental trauma varied from 13.2% to 25.7%. A certain level of trauma was expected because athletes are at major risk of trauma when practising sports, and individual characteristics, such as poor lip closure, slow response to environmental obstacles, slow reflexes or large overjet of maxillary incisors, increase the risk of traumatic oral injuries (23,24,25).…”

Section: Discussionmentioning

confidence: 99%

Oral health needs of athletes with intellectual disability in Eastern Europe: Poland, Romania and Slovenia

Rojas

Wichrowska-Rymarek

Pavlič

et al. 2016

International Dental Journal

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Analysis of the results obtained following screening showed comparable oral health needs of athletes with intellectual disability among countries. Exploration of the oral health systems of the countries revealed similar significant co-payments and lack of incentive for dentists to treat patients with special needs. The results from Romania, Poland and Slovenia demonstrated the need for a structured system in which a special population is a target for oral-health-related education programmes and system-included preventive, restorative and maintenance interventions.

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Section: Discussionmentioning

confidence: 99%

Oral health needs of athletes with intellectual disability in Eastern Europe: Poland, Romania and Slovenia

Rojas

Wichrowska-Rymarek

Pavlič

et al. 2016

International Dental Journal

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Sex differences in quadrupedal walking gaits of Uner Tan syndrome cases, healthy humans and nonhuman primates

Tan

2017

Neurological Research

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Disease Gene Prioritization Using Network and Feature

Xie

Agam

Balasubramanian

et al. 2015

Journal of Computational Biology

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Identifying high-confidence candidate genes that are causative for disease phenotypes, from the large lists of variations produced by high-throughput genomics, can be both timeconsuming and costly. The development of novel computational approaches, utilizing existing biological knowledge for the prioritization of such candidate genes, can improve the efficiency and accuracy of the biomedical data analysis. It can also reduce the cost of such studies by avoiding experimental validations of irrelevant candidates. In this study, we address this challenge by proposing a novel gene prioritization approach that ranks promising candidate genes that are likely to be involved in a disease or phenotype under study. This algorithm is based on the modified conditional random field (CRF) model that simultaneously makes use of both gene annotations and gene interactions, while preserving their original representation. We validated our approach on two independent disease benchmark studies by ranking candidate genes using network and feature information. Our results showed both high area under the curve (AUC) value (0.86), and more importantly high partial AUC (pAUC) value (0.1296), and revealed higher accuracy and precision at the top predictions as compared with other well-performed gene prioritization tools, such as Endeavour (AUC-0.82, pAUC-0.083) and PINTA (AUC-0.76, pAUC-0.066). We were able to detect more target genes (9/18/19/27) on top positions (1/5/10/20) compared to Endeavour (3/11/14/23) and PINTA (6/10/13/18). To demonstrate its usability, we applied our method to a case study for the prediction of molecular mechanisms contributing to intellectual disability and autism. Our approach was able to correctly recover genes related to both disorders and provide suggestions for possible additional candidates based on their rankings and functional annotations.

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Latest Findings in Intellectual and Developmental Disabilities Research

Cited by 8 publications

References 428 publications

Oral health needs of athletes with intellectual disability in Eastern Europe: Poland, Romania and Slovenia

Oral health needs of athletes with intellectual disability in Eastern Europe: Poland, Romania and Slovenia

Sex differences in quadrupedal walking gaits of Uner Tan syndrome cases, healthy humans and nonhuman primates

Disease Gene Prioritization Using Network and Feature

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