Lateralized impairment of the emotional enhancement of verbal memory in patients with amygdala–hippocampus lesion

Frank, Jean Edith; Tomaz, Carlos

doi:10.1016/s0278-2626(03)00075-7

Cited by 27 publications

(12 citation statements)

References 21 publications

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“…However, as a limitation we did not examine the arousal levels in the study. Furthermore, previous research highlighted amygdalar volume as the best predictor of EEM in AD [43] and impaired EEM for verbal material was related to left amygdalar dysfunction [50]. Therefore, asymmetrical involvement of the left amygdala may be responsible for isolated EEM deficiency for verbal stimuli in these patients.…”

Section: Discussionmentioning

confidence: 89%

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

Baran

Cangöz²,

Ozel-Kizil³

2014

Eur Neurol

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Emotional enhancement of memory (EEM) has been a well-known phenomenon which corresponds to the advantage of emotional stimuli to be better recalled than neutral ones. Previous studies suggest that aging favours recollection of positive items and this pattern is disrupted in Alzheimer's disease (AD). Emotional valence of different stimulus modalities, i.e. pictures and words, may also have an effect on each other's memory performances. However, none of these were clearly studied in AD. This study aimed to evaluate how emotional valences of simultaneously presented stimuli affected recall in healthy young (YG, n = 30), healthy elderly (HE, n = 30) participants and in patients with AD (n = 30). A battery consisting of emotional words presented on emotional pictures was developed. An analysis of a 3 (Groups) × 3 (Emotional Valence of Picture) × 3 (Emotional Valence of Word) mixed ANOVA design was carried out. Patients with AD could process emotional information similarly to healthy participants; however, they had EEM only for picture recalling. Emotional valence of the co-presented stimulus had a boosting effect both in the YG and HE, but not in AD group, especially if both of the stimuli had the same emotional valence. This study highlights the impaired EEM for verbal and preserved EEM for non-verbal declarative memory in patients with AD, the neurobiological underpinnings of which should be addressed by future studies.

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Section: Discussionmentioning

confidence: 89%

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

Baran

Cangöz²,

Ozel-Kizil³

2014

Eur Neurol

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“…Some functional imaging studies which directly compared positive and negative material found the predicted lateralized pattern of amygdala activation (Canli et al, 1998; Zalla et al, 2000), while others reported bilateral (Garavan et al, 2001; Yang et al, 2002) or left-lateralized amygdala activation for both valences (Schneider et al, 1997; Hamann and Mao, 2002). Consistent with this latter finding, the majority of studies examining emotional processing (Morris et al, 1998; Canli et al, 2000; Zalla et al, 2000) and long-term memory (LaBar and Phelps, 1998; Adolphs et al, 2000; Buchanan et al, 2001; Frank and Tomaz, 2003) for either negative or positive material found primarily left-sided amygdala involvement for both valences (for an overview see Wager et al, 2003; Zald, 2003; Beraha et al, 2012). Thus, these results suggest that the right amygdala may play a weaker role in emotional memory enhancement compared to the left amygdala (LaBar and Phelps, 1998; Adolphs et al, 2000; Buchanan et al, 2001; Meletti et al, 2003, 2009) and that the processing of negative stimuli may be subserved by the bilateral amygdalae (Liberzon et al, 2000; Hamann et al, 2002; Ritchey et al, 2008; Baeken et al, 2009).…”

Section: Introductionmentioning

confidence: 75%

“…This result corroborates previous findings suggesting that the left amygdala facilitates the on-line processing of especially verbal emotional stimuli (Anderson and Phelps, 2001; Hamann and Mao, 2002) and may help to explain why the left amygdala is more often associated with the processing of both valences compared to the right amygdala in the previous literature on emotional long-term memory processing (cf. Adolphs et al, 2000; Buchanan et al, 2001; Frank and Tomaz, 2003). That is, while the left amygdala may support the encoding of both positive and negative items as well as the consolidation of positive material, the right amygdala may primarily support the consolidation of negative material.…”

Section: Discussionmentioning

confidence: 99%

Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease

Mistridis

Taylor

Kißler

et al. 2014

Front. Hum. Neurosci.

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Emotional information is typically better remembered than neutral content, and previous studies suggest that this effect is subserved particularly by the amygdala together with its interactions with the hippocampus. However, it is not known whether amygdala damage affects emotional memory performance at immediate and delayed recall, and whether its involvement is modulated by stimulus valence. Moreover, it is unclear to what extent more distributed neocortical regions involved in e.g., autobiographical memory, also contribute to emotional processing. We investigated these questions in a group of patients with Alzheimer's disease (AD), which affects the amygdala, hippocampus and neocortical regions. Healthy controls (n = 14), patients with AD (n = 15) and its putative prodrome amnestic mild cognitive impairment (n = 11) completed a memory task consisting of immediate and delayed free recall of a list of positive, negative and neutral words. Memory performance was related to brain integrity in region of interest and whole-brain voxel-based morphometry analyses. In the brain-behavioral analyses, the left amygdala volume predicted the immediate recall of both positive and negative material, whereas at delay, left and right amygdala volumes were associated with performance with positive and negative words, respectively. Whole-brain analyses revealed additional associations between left angular gyrus integrity and the immediate recall of positive words as well as between the orbitofrontal cortex and the delayed recall of negative words. These results indicate that emotional memory impairments in AD may be underpinned by damage to regions implicated in emotional processing as well as frontoparietal regions, which may exert their influence via autobiographical memories and organizational strategies.

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“…This criticism is tempered by the fact that several previous studies have identified deficits in emotion related processing following unilateral amygdala lesions (Adolphs, Tranel, & Damasio, 2001; Akiyama et al, 2007; Anderson, Spencer, Fulbright, & Phelps, 2000; Bechara et al, 1995; Benuzzi et al, 2004; Coppens, van Paesschen, Vandenbulcke, & Vansteenwegen, 2010; Frank & Tomaz, 2003; LaBar, LeDoux, Spencer, & Phelps, 1995). Although deficits after unilateral lesions are not always as severe as those found after bilateral damage, these studies support the notion that unilateral damage can be sufficient to disrupt normal emotional processing.…”

Section: Discussionmentioning

confidence: 99%

Attentional capture by emotional stimuli is preserved in patients with amygdala lesions

et al. 2011

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The importance of cues signaling reward, threat or danger would suggest that they receive processing privileges in the neural systems underlying perception and attention. Previous research has documented enhanced processing of motivationally salient cues, and has pointed to the amygdala as a candidate neural structure underlying the enhancements. In the current study, we examined whether the amygdala was necessary for this emotional modulation of attention to occur. Patients with unilateral amygdala lesions and matched controls completed an emotional attentional blink task in which emotional distractors impair the perception of subsequent targets. Emotional images proved more distracting across all participant groups, including those with right or left amygdala lesions. These data argue against a central role for the amygdala in mediating all types of attentional capture by emotional stimuli.

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Lateralized impairment of the emotional enhancement of verbal memory in patients with amygdala–hippocampus lesion

Cited by 27 publications

References 21 publications

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease

Attentional capture by emotional stimuli is preserved in patients with amygdala lesions

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