Lateralized and widespread brain activation during transient blood pressure elevation revealed by magnetic resonance imaging

Harper, Ronald M.; Bandler, Richard; Spriggs, Dale R.; Alger, Jeffry R.

doi:10.1002/(sici)1096-9861(20000207)417:2<195::aid-cne5>3.0.co;2-v

Cited by 140 publications

(102 citation statements)

References 32 publications

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“…The functional neuroimaging of adults have found concomitant increases in amygdalar activation and measures of autonomic arousal such as skin conductance [37], blood pressure [11,12] and heart rate [4,15].…”

Section: Discussionmentioning

confidence: 99%

“…The researchers observed that mean skin conductance level was positively correlated with right amygdala activity. By using different pressor challenges to elevate blood pressure, two fMRI studies in normal adults found that the pressor challenges elicited significant regional fMRI signal changes in the amygdala [11,12]. To address the question of central control of heart rate in emotions, parallel measurement of heart rate changes and changes in activation as indexed by fMRI was performed on normal adults [15].…”

Section: Introductionmentioning

confidence: 99%

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Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects

Yang

Simmons

Matthews

et al. 2007

Neuroscience Letters

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Emotions have been conceptualized as representations of bodily responses to a stimulus that critically involves the autonomic nervous system (ANS). An association between amygdala activation and ANS activity has been shown in adults. However, to date, no studies have demonstrated this association in adolescents. Examining the interaction between the ANS and amygdala in healthy adolescents may provide information about age-related changes in the association between amygdala activation and ANS measures. Therefore, the aim of this study was to examine the relationship between amygdala activation and heart rate in normal adolescents. Eighteen 12-to 17-year old adolescents participated. Heart rate data was collected during functional magnetic resonance imaging while subjects performed a facial expression matching task that reliably activates the amygdala. Adolescents showed significant amygdala activation for all facial expressions relative to the shapematching, control task. Moreover, the degree of activation in the right amygdala for Fearful faces was significantly correlated with heart rate (Spearman's rho = 0.55, p = 0.018, two-tailed). This study shows that amygdala activity is related to heart rate in healthy adolescents. Thus, similar to adults, adolescents show a coupling between processing emotional events and adjusting the ANS accordingly. Furthermore, this study confirms previous adolescent studies showing amygdala activation to Fearful, Angry, and Happy faces. Finally, the results of the present study lay the foundation for future research to investigate whether adolescents with mood or anxiety disorders show an altered coupling between processing emotionally salient events and ANS activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects

Yang

Simmons

Matthews

et al. 2007

Neuroscience Letters

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“…Therefore, we should expect that deactivation of the cingulate cortex might be observed in association with a relief from breathing difficulty by mandibular advancement. The cingulate cortex is also linked to central cardiovascular control mechanisms (15) and is activated by blood pressure challenges (21). Furthermore, it has been reported that there is a loss of gray matter in the cingulate cortex in subjects with OSA (36), who exhibit an increased risk of cardiovascular disorders and stroke.…”

Section: Deactivation In Cortical and Subcortical Regions Associated mentioning

confidence: 99%

Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study

Hashimoto¹,

Ono²,

Honda³

et al. 2006

Journal of Applied Physiology

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. Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study. J Appl Physiol 100: 579 -586, 2006. First published September 29, 2005 doi:10.1152/japplphysiol.00169.2005.-Oral appliances have been a popular treatment option for subjects with obstructive sleep apnea. However, little information is available on how brain activation induced by respiratory challenge is modulated by mandibular advancement with these appliances. We hypothesized that the brain activation caused by respiratory stress may be alleviated by mandibular advancement. Respiratory stress was induced in 12 healthy subjects by resistive inspiratory loading. The effects of mandibular advancement during resistive inspiratory loading were assessed subjectively by using a visual analog scale. These effects were also evaluated objectively by using blood oxygenation level-dependent functional magnetic resonance imaging. The score for the visual analog scale significantly decreased with mandibular advancement. Cortical deactivation, in association with mandibular advancement, was localized to several specific regions, including the left cingulate gyrus and the bilateral prefrontal cortexes. These regions are known to be involved in respiratory control. Our results suggest that mandibular advancement with an oral appliance appears to be useful for reducing respiratory stress, based on both subjective and neuronal criteria.

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“…Functional magnetic resonance imaging (fMRI) using the Blood Oxygenation Level Dependent [1] technique can be useful in visualizing brain areas involved in mediating cardiac and respiratory challenges [2]. Typically, physiological challenges are applied to monitor healthy neural responses to changing blood pressure.…”

Section: Introductionmentioning

confidence: 99%

“…The model has the advantage of simplicity, and allows easy comparison across subjects by averaging procedures. Neural signal changes in response to physiological challenges have been modeled previously using a boxcar model [2]. In some cases, however, a boxcar model may be inappropriate, since fMRI signal changes may be more closely related to momentary physiological alterations, or the neural responses may not follow the step function intrinsic to the boxcar design.…”

Section: Introductionmentioning

confidence: 99%

Neural signal changes associated with cardiac and respiratory measures vs boxcar analysis in functional magnetic resonance imaging (fMRI)

Macey

Macey²,

Woo³

et al.

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Functional magnetic resonance imaging (fMRI) was used to measure signal changes in the brain during a respiratory challenge that elevated blood pressure. Subjects were scanned during a baseline period and during a Valsalva maneuver. Results were compared using fixed-effects analysis with the SPM99 package, and examined once using a boxcar model and once by models generated from changes in cardiac and respiratory signals during the breathing challenge. Models based on physiological measures resulted in greater localization of signal changes.

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Lateralized and widespread brain activation during transient blood pressure elevation revealed by magnetic resonance imaging

Cited by 140 publications

References 32 publications

Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects

Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects

Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study

Neural signal changes associated with cardiac and respiratory measures vs boxcar analysis in functional magnetic resonance imaging (fMRI)

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