Lateralization of responses to vibrissal stimulation: Connectivity and information integration in the rat sensory-motor cortex assessed with fMRI

Alonso, Benito de Celis; Sergeyeva, Marina; Brune, Kay; Heß, Andreas

doi:10.1016/j.neuroimage.2012.05.045

Cited by 12 publications

(16 citation statements)

References 64 publications

(68 reference statements)

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“…Neurons of the whisker barrel system in the rodent primary somatosensory cortex are known to encode external events in time and space and thus offer an excellent model to study BOLD activation processes (de Celis Alonso et al, 2012;Lu et al, 2003;Yang et al, 1996Yang et al, , 1997. The rat barrel cortex can also be reliably and reproducibly activated through trigeminal nerve (TGN) stimulation (Nielsen and Lauritzen, 2001;Just et al, 2010;Fanselow and Nicolelis, 1999).…”

Section: Introductionmentioning

confidence: 99%

Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences

Just¹,

Xin²,

Frenkel³

et al. 2013

NeuroImage

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To date, only a couple of functional MR spectroscopy (fMRS) studies were conducted in rats. Due to the low temporal resolution of 1 H MRS techniques, prolonged stimulation paradigms are necessary for investigating the metabolic outcome in the rat brain during functional challenge. However, sustained activation of cortical areas is usually difficult to obtain due to neural adaptation. Anesthesia, habituation, high variability of the basal state metabolite concentrations as well as low concentrations of the metabolites of interest such as lactate (Lac), glucose (Glc) or γ-aminobutyric acid (GABA) and small expected changes of metabolite concentrations need to be addressed. In the present study, the rat barrel cortex was reliably and reproducibly activated through sustained trigeminal nerve (TGN) stimulation. In addition, TGN stimulation induced significant positive changes in lactate (+1.01 μmol/g, p b 0.008) and glutamate (+0.92 μmol/g, p b 0.02) and significant negative aspartate changes (−0.63 μmol/g, p b 0.004) using functional 1 H MRS at 9.4 T in agreement with previous changes observed in human fMRS studies. Finally, for the first time, the dynamics of lactate, glucose, aspartate and glutamate concentrations during sustained somatosensory activation in rats using fMRS were assessed. These results allow demonstrating the feasibility of fMRS measurements during prolonged barrel cortex activation in rats.

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Section: Introductionmentioning

confidence: 99%

Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences

Just¹,

Xin²,

Frenkel³

et al. 2013

NeuroImage

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“…It has been reported using fMRI that right-hemisphere structures are more dominant for righthanded humans (51) and animals (52). Lesions to this hemisphere decrease the ability to detect and distinguish smells more than to the left hemisphere (53).…”

Section: Lateralizationunclassified

Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children

Hidalgo-Tobón

Suárez²,

Pérez³

et al. 2020

Preprint

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Introduction: Lisdexamfetamine (LDX) is a drug used to treat ADHD/impulsive patients. Impulsivity is known to affect inhibitory, emotional and cognitive function. On the other hand, smell and odor processing are known to be affected by neurological disorders, as they are modulators of addictive and impulsive behaviors specifically. We hypothesize that, after LDX ingestion, inhibitory pathways of the brain would change, and complementary behavioral regulation mechanisms would appear to regulate decision-making and impulsivity.Methods: 20 children were studied in an aleatory crossover study. Imaging of BOLD-fMRI activity, elicited by olfactory stimulation in impulsive children, was performed after either LDX or placebo ingestion. Results:Findings showed that all subjects that underwent odor stimulation presented activations of similar intensities in the olfactory centers of the brain. This contrasted with inhibitory regions of the brain such as the cingulate cortex and frontal lobe regions, which demonstrated changed activity patterns and intensities. While some differences between the placebo and medicated states were found in motor areas, precuneus, cuneus, calcarine, supramarginal, cerebellum and posterior cingulate cortex, the main changes were found in frontal, temporal and parietal cortices. When comparing olfactory cues separately, pleasant food smells like chocolate seemed not to present large differences between the medicated and placebo scenarios, when compared to non-food-related smells. Conclusions:We demonstrated that LDX, first, altered the inhibitory pathways of the brain, second, increased activity in large amounts of brain regions which were not activated by smell in drug-naïve patients, third, facilitated a complementary behavioral regulation mechanism, run by the cerebellum, which regulated decision-making and impulsivity in motor and frontal structures.

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“…Immediately after, rat whiskers were trimmed on both sides of the snout with exception of the ones in the C row. Rats were then mounted on a Plexiglas cradle with incorporated mouth mask and with a tooth biting bar where the rat's head was fixed without the need of ear screws [see de Celis Alonso et al (2012) for details on experimental setup].…”

Section: Animal Preparationmentioning

confidence: 99%

“…Fig 2). BOLD activation induced by whisker stimulation was analyzed using standard procedures described by de Celis Alonso et al (2012). After appropriate preprocessing including interslice-time correction, motion correction, and spatial and temporal smoothing, a general linear model (GLM) analysis was performed (for detailed information see Supplementary Methods).…”

Section: Analysis Of Bold Activation Due To Whisker Stimulationmentioning

confidence: 99%

“…Unilateral whisker activation usually indicates food or foe; thus the animal reacts with an immediate behavioral and emotional response (Marshall et al, 1971;Prescott, 2011). When compared to the more natural stimulation of all whiskers, trimming and stimulation of the remaining whiskers induces altered functional activation patterns that are shown to be related to plasticity and learning processes (Albieri et al, 2015;Alonso Bde et al, 2008;de Celis Alonso et al, 2012;Mirabella et al, 2001;Sellien and Ebner, 2007).…”

Section: Introductionmentioning

confidence: 99%

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A new analysis of resting state connectivity and graph theory reveals distinctive short-term modulations due to whisker stimulation in rats

Kreitz

Alonso

Uder

et al. 2017

Preprint

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Resting state (RS) connectivity has been increasingly studied in healthy and diseased brains in humans and animals. This paper presents a new method to analyze RS data from fMRI that combines multiple seed correlation analysis with graph-theory (MSRA). We characterize and evaluate this new method in relation to two other graph-theoretical methods and ICA. The graph-theoretical methods calculate cross-correlations of regional average time-courses, one using seed regions of the same size (SRCC) and the other using whole brain structure regions (RCCA). We evaluated the reproducibility, power, and capacity of these methods to characterize short term RS modulation to unilateral physiological whisker stimulation in rats.Graph-theoretical networks found with the MSRA approach were highly reproducible, and their communities showed large overlaps with ICA components. Additionally, MSRA was the only one of all tested methods that had the power to detect significant RS modulations induced by whisker stimulation that are controlled by family-wise error rate (FWE).Compared to the reduced resting state network connectivity during task performance, these modulations implied decreased connectivity strength in the bilateral sensorimotor and entorhinal cortex. Additionally, the contralateral ventromedial thalamus (part of the barrel field related lemniscal pathway) and the hypothalamus showed reduced connectivity.Enhanced connectivity was observed in the amygdala, especially the contralateral basolateral amygdala (involved in emotional learning processes). In conclusion, MSRA is a powerful analytical approach that can reliably detect tiny modulations of RS connectivity. It shows a great promise as a method for studying RS dynamics in healthy and pathological conditions.

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Lateralization of responses to vibrissal stimulation: Connectivity and information integration in the rat sensory-motor cortex assessed with fMRI

Cited by 12 publications

References 64 publications

Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences

Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences

Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children

A new analysis of resting state connectivity and graph theory reveals distinctive short-term modulations due to whisker stimulation in rats

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