Lateralization of choline acetyltransferase (ChAT) activity in fetus and adult human brain

Bracco, Laura; Tiezzi, Antonio; Ginanneschi, A.; Campanella, Chiara; Amaducci, L.

doi:10.1016/0304-3940(84)90503-2

Cited by 26 publications

(6 citation statements)

References 13 publications

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“…In both cases, the changes were associated with the more marked decreases of the HACU in the L side [3]. Our experiments supported previous studies reporting L/R asymmetry of the cholinergic neurotransmitter system in young rat/human brains (e.g., [4][5][6]) and the HAROLD model [2]. Yet laterality of the HACU has not been estimated in the hippocampi of Long Evans rats, i.e., of the strain currently used, e.g., in pharmacological modeling of various diseases.…”

Section: Introductionsupporting

confidence: 89%

“…2. The activities of eNOS in young Wistar rats markedly differed from those in young Long Evans rats ( Human brains: L/R asymmetry of various cholinergic markers and its age-dependent decrease was observed in different brain structures including the hippocampi (e.g., [4][5][6]). The L regions are affected earlier and/or more severely in AD (for review see [1])…”

Section: Resultsmentioning

confidence: 93%

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Aging and Lateralization of the Rat Brain on a Biochemical Level

Krištofíková

Říčný

Ort³

et al. 2010

Neurochem Res

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It has been suggested that the lateralization of the human brain underlies hemispheric specialization and that it can be observed also on a biochemical level. Biochemical laterality appears to be a basis of volumetric or functional asymmetry but direct relationships among them are still unclear. Moreover, age-related differences between the right and left hemispheres are not well documented in various rat strains. In the current study, biochemical markers sensitive to Alzheimer disease (activities of high-affinity choline uptake and of nitric oxide synthases, expression of 17beta-hydroxysteroid dehydrogenase type 10) were estimated in both hemispheres of young and old male Wistar/Long Evans rats. Our experiments indicate (1) differences in some biochemical markers between young Wistar and Long Evans rats (the activities of endothelial nitric oxide synthase are higher in Long Evans and those of citrate synthase in Wistar rats), (2) more similar brain asymmetry of healthy human/young Wistar brains when compared to those of young Long Evans, (3) the decrease in asymmetry of the physiologically left/right lateralized biomarker during aging (the activity of the high-affinity choline uptake decreases more markedly in the left side of old Wistar rats) in accordance with the HAROLD model, (4) the age-related shift to reversed left/right asymmetry of the physiologically right/left lateralized biomarker (the activity of inducible nitric oxide synthase increases especially in the left side of old Long Evans rats), and finally (5) age-related differences in physiologically unlateralized biomarkers between Wistar and Long Evans rats (changes in the activities of neural/endothelial nitric oxide synthases or in expression of 17beta-hydroxysteroid dehydrogenase type 10 are more asymmetrical in old Wistar when compared to rather bilateral alterations of old Long Evans animals). It seems that the physiological lateralization of the human or rat brains on a biochemical level and their age-related alterations are dependent on biomarker type/function. By our opinion, it is difficult, perhaps impossible, to make one simple universal model, at least on a biochemical level. Since lateral analyses are of sufficient sensitivity to reveal subtle links, we recommend using Wistar rather than Long Evans rats in modeling of diseases accompanied by alterations in brain asymmetry.

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Section: Introductionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 93%

Aging and Lateralization of the Rat Brain on a Biochemical Level

Krištofíková

Říčný

Ort³

et al. 2010

Neurochem Res

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“…The authors proposed that the tendency toward higher FA and λ 1 values at the right PIC may reflect a greater degree of right hemispheric white matter organization. This finding is consistent with postmortem data, indicating an earlier morphological maturation and gyration of right-sided fetal brain structures [50,[59][60][61][62][63].…”

Section: Observed Structures 231 Structural Findingssupporting

confidence: 92%

Advanced fetal MRI: Diffusion tensor imaging, spectroscopy, dynamic MRI, resting-state functional MRI

Soman

Kasprian

Schöpf

et al. 2015

J Pediatr Neuroradiol

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Fetal magnetic resonance imaging is playing an increasingly important role in troubleshooting diagnostically uncertain fetal ultrasound examinations. Recent advances in imaging speed and post processing of fetal images have enabled new applications of advanced neural imaging techniques to fetal imaging. This paper reviews recent developments in the topics of fetal diffusion tensor imaging, fetal spectroscopy, fetal dynamic imaging and resting state fetal magnetic resonance imaging.

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“…Since 1989, we added several experimental supports to these scenarios: we confirmed our first finding that the right hemisphere advantage for individual face recognition is present at 4 -5 months of age and during the first year (de Schonen et al, 1986;de Schonen and Mathivet, 1990), whereas recognition of facedness can be performed equally well by the two hemispheres (de Schonen and Bry, 1987); the right hemisphere advantage in configural processing and the left hemisphere advantage for more local processing in geometrical patterns was observed in 5 -11-month-olds de Schonen, 1991, 1995), as well as in individual face processing (Deruelle and de Schonen, 1998). In addition, the finding that there is more activity in the right rather than in the left temporal cortex (as measured by PET with H 2 O 15 as a marker), when 2-months-olds view faces or other visual patterns, but no asymmetry in the parietal and occipital cortices, may indicate a wave of earlier maturation in the right temporal cortex as predicted by the scenario on the basis of other data (Bracco et al, 1984;Scheibel, 1993;. Moreover, greater activity in the temporal cortex on both sides, under the face presentations than under the circle presentation (control situation), might indicate that this region is already involved in complex visual pattern processing, as it is the case in adults.…”

Section: Timing Issues: In Search Of a Methodologymentioning

confidence: 88%

Comments on ‘developmental cognitive neuroscience. an introduction’ by M.H. Johnson

Schonen

1998

Early Dev. Parent.

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Lateralization of choline acetyltransferase (ChAT) activity in fetus and adult human brain

Cited by 26 publications

References 13 publications

Aging and Lateralization of the Rat Brain on a Biochemical Level

Aging and Lateralization of the Rat Brain on a Biochemical Level

Advanced fetal MRI: Diffusion tensor imaging, spectroscopy, dynamic MRI, resting-state functional MRI

Comments on ‘developmental cognitive neuroscience. an introduction’ by M.H. Johnson

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