Lateralization effects on functional connectivity of the auditory network in patients with unilateral pulsatile tinnitus as detected by functional MRI

Lv, Han; Zhao, Pengfei; Liu, Zhaohui; Liu, Xuehuan; Ding, Heyu; Liu, Liheng; Wang, Guo‐Peng; Xie, Jing; Zeng, Rong; Chen, Yu‐Chen; Yang, Zhenghan; Gong, Shusheng; Wang, Zhenchang

doi:10.1016/j.pnpbp.2017.09.020

Cited by 18 publications

(20 citation statements)

References 62 publications

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“…Surprisingly, almost all the abnormal FC patterns especially for the dACC were lateralized to the right hemisphere region in right-sided tinnitus patients. Asymmetry for the tinnitus patients has been reported both structurally and functionally (Smits et al, 2007 ; Landgrebe et al, 2009 ; Chen et al, 2014 ; Geven et al, 2014 ; Lanting et al, 2014 ; Lv et al, 2017 ). Prior PET studies have revealed higher resting-state metabolic activity in right associative auditory brain areas (Geven et al, 2014 ).…”

Section: Discussionmentioning

confidence: 98%

Abnormal Resting-State Functional Connectivity of the Anterior Cingulate Cortex in Unilateral Chronic Tinnitus Patients

Chen

Liu

et al. 2018

Front. Neurosci.

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Purpose: The anterior cingulate cortex (ACC) has been suggested to be involved in chronic subjective tinnitus. Tinnitus may arise from aberrant functional coupling between the ACC and cerebral cortex. To explore this hypothesis, we used resting-state functional magnetic resonance imaging (fMRI) to illuminate the functional connectivity (FC) network of the ACC subregions in chronic tinnitus patients.Methods: Resting-state fMRI scans were obtained from 31 chronic right-sided tinnitus patients and 40 healthy controls (age, sex, and education well-matched) in this study. Rostral ACC and dorsal ACC were selected as seed regions to investigate the intrinsic FC with the whole brain. The resulting FC patterns were correlated with clinical tinnitus characteristics including the tinnitus duration and tinnitus distress.Results: Compared with healthy controls, chronic tinnitus patients showed disrupted FC patterns of ACC within several brain networks, including the auditory cortex, prefrontal cortex, visual cortex, and default mode network (DMN). The Tinnitus Handicap Questionnaires (THQ) scores showed positive correlations with increased FC between the rostral ACC and left precuneus (r = 0.507, p = 0.008) as well as the dorsal ACC and right inferior parietal lobe (r = 0.447, p = 0.022).Conclusions: Chronic tinnitus patients have abnormal FC networks originating from ACC to other selected brain regions that are associated with specific tinnitus characteristics. Resting-state ACC-cortical FC disturbances may play an important role in neuropathological features underlying chronic tinnitus.

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Section: Discussionmentioning

confidence: 98%

Abnormal Resting-State Functional Connectivity of the Anterior Cingulate Cortex in Unilateral Chronic Tinnitus Patients

Chen

Liu

et al. 2018

Front. Neurosci.

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“…Few previous fMRI studies on patients with PT reported alterations in the parahippocampal gyrus. 9,17 This brain region has been considered to play a key role in tinnitus habituation. Studies have consistently found that the parahippocampal gyrus is functionally connected to the auditory cortex and dorsal attention network.…”

Section: Discussionmentioning

confidence: 99%

“…10 However, altered FC between the MTG and the DMN and auditory network was detected. 9,17 The right MTG was found to be much more vulnerable than the left. 17 Nonetheless, the role of the MTG in PT patients is still far from clear.…”

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confidence: 95%

“…8 Several studies have reported that resting-state functional magnetic resonance imaging (rs-fMRI) is an appropriate method for exploring neuropathophysiological changes in patients with PT. 9,10 Previous studies have noted disrupted brain activity in PT patients, as indicated by abnormal local field spontaneous neural activity and imbalanced functional connectivity (FC) between auditory and nonauditory brain regions. Among several other cortical brain regions, the right middle temporal gyrus (MTG) is considered to be critically involved in neural functional alterations in tinnitus patients.…”

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confidence: 99%

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Long‐term reactions to pulsatile tinnitus are marked by weakened short‐range functional connectivity within a brain network in the right temporal lobe

Wang

Zhang

Zhao

et al. 2018

Magnetic Resonance Imaging

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Background There have been recent efforts to characterize brain functional activity features in patients with pulsatile tinnitus (PT). These efforts have revealed evidence of aberrant functional connectivity (FC) of the right middle temporal gyrus (MTG) in PT patients with prolonged disease duration. Purpose To assess the possible predictive effect of aberrant FC of MTG in PT patients with prolonged disease duration. Study Type Retrospective. Population Thirty‐four patients with recent‐onset PT (RPTIN), 24 patients with long‐term PT (LPTIN), and 35 age‐, gender‐, and education‐matched healthy controls were enrolled. Field Strength/Sequence 3.0T MRI system and echo‐planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence. Assessment Functional MRI data preprocessing was performed in Data Processing & Analysis for Brain Imaging (DPABI) and Statistical Parametric Mapping (SPM) 8. The FC analyses were conducted using the software REST. Statistical Tests One‐way analysis of covariance was conducted between three groups with age and gender as covariates, and post‐hoc analysis was used to identify the sources of group effects. Pearson's correlation analysis was conducted for the z‐values of altered FC strength in the PT group and the clinical data. Results Among hubs belonging to the executive control network, the default mode network (DMN), and limbic network, the strength of FC was mainly decreased in the patient groups compared with normal controls (P < 0.05). Relative to RPTIN patients and normal controls, LPTIN patients were further characterized by significantly decreased FC between several short‐range brain regions adjacent to the seed (P < 0.05). Finally, disease duration was negatively correlated with decreased FC between the seed and right fusiform gyrus/parahippocampal gyrus, right inferior frontal gyrus, and right MTG (a brain area adjacent to the seed region). Data Conclusion Long‐term reactions to PT mainly involved weakened short‐range FC, especially within a functional network in the right temporal lobe. Level of Evidence: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

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“…According to our previous research, tinnitus has been proven to be a symptom characterized by abnormal resting-state functional magnetic resonance imaging (rs-fMRI) (11)(12)(13)(14). The brain regions involved include sound detection regions, such as the insula and hippocampus (15,16), and auditory and nonauditory brain regions (17), such as the parahippocampal gyrus (18), posterior cingulate cortex (19), and anterior cingulate cortex (20).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

Qian

et al. 2020

Preprint

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Background: Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Methods: Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and at the 24th week). Two-sample t tests, paired-samples t tests, and Pearson’s correlation analysis were used in the post hoc analysis.Results: Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality and nodal betweenness centrality after FDR correction. Decreased THI scores and GM volume changes between the left thalamus and right thalamus were not correlated. Conclusions: This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

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Lateralization effects on functional connectivity of the auditory network in patients with unilateral pulsatile tinnitus as detected by functional MRI

Cited by 18 publications

References 62 publications

Abnormal Resting-State Functional Connectivity of the Anterior Cingulate Cortex in Unilateral Chronic Tinnitus Patients

Abnormal Resting-State Functional Connectivity of the Anterior Cingulate Cortex in Unilateral Chronic Tinnitus Patients

Long‐term reactions to pulsatile tinnitus are marked by weakened short‐range functional connectivity within a brain network in the right temporal lobe

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

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