Laterality dissociation of ventral hippocampus inhibition in learning and memory, glial activation and neural arborization in response to chronic stress in male Wistar rats

Brojeni, Masoud Shareghi; Korani, Mohsen; Meftahi, Gholam Hossein; Davoodian, Nahid; Hadipour, Mohammadmehdi; Jahromi, Gila Pirzad

doi:10.1016/j.jchemneu.2022.102090

Cited by 2 publications

(3 citation statements)

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“…In a recent study, Virmani et al (2021) exposed adult male mice to CUS and found no differences in astrocyte morphology in the dorsal CA3, as well as in the number of astrocytes in CA1. Interestingly, there is evidence indicating increases in GFAP expression in prefrontal cortex and in whole hippocampal area in adult male rats after CUS (Rao et al, 2021) or chronic restraint stress (Brojeni et al, 2022). Duration of chronic stress exposure is another factor that could explain the inconsistencies, as prolonged exposure to CUS (12 weeks) increased GFAP expression in the DG of adult male rats (du Preez et al, 2021).…”

Section: Effects Of Ee and Cus On Gfap Expression In The Hippocampusmentioning

confidence: 99%

“…Animal studies exploring the effects of chronic stress on GFAP expression often present inconsistent results that can be partially explained by differences in GFAP expression in certain hippocampal subregions as a function of stress (Balog et al., 2022; Brojeni et al., 2022; Li et al., 2020; Rao et al., 2021; Virmani et al., 2021). For example, hippocampal GFAP expression was decreased after chronic stress when the whole hippocampus was examined (Barbosa et al., 2017; Liu et al., 2009; Yao et al., 2021), but no difference was found in astrocyte morphology in the dorsal CA3, as well as in the number of astrocytes in CA1 of male rodents (Virmani et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

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Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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This study aims at investigating whether environmental enrichment (EE) initiated in adolescence can alter chronic unpredictable stress (CUS)‐associated changes in astroglial and synaptic plasticity markers in male and female rats. To this end, we studied possible alterations in hippocampal glial fibrillary acidic protein (GFAP) and synaptophysin (SYN) in CUS rats previously housed in EE. Wistar rats on postnatal day (PND) 23 were housed for 10 weeks in standard housing (SH) or enriched conditions. On PND 66, animals were exposed to CUS for 4 weeks. SYN and GFAP expressions were evaluated in CA1 and CA3 subfields and dentate gyrus (DG). CUS reduced the expression of SYN in all hippocampal areas, whereas lower GFAP expression was evident only in CA1 and CA3. The reduced expression of SYN in DG and CA3 was evident to male SH/CUS rats, whereas the reduced GFAP expression in CA1 and CA3 was limited to SH/CUS females. EE housing increased the hippocampal expression of both markers and protected against CUS‐associated decreases. Our findings indicate that the decreases in the expression of SYN and GFAP following CUS are region and sex‐specific and underline the neuroprotective role of EE against these CUS‐associated changes.

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Section: Effects Of Ee and Cus On Gfap Expression In The Hippocampusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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“…Cunha, Machado (42) revealed that the antidepressant-like activity of creatine seems to be mediated by the activation of dopamine D1 and D2 receptors and probably a modulation of dopamine reuptake. Many studies have demonstrated that chronic stress causes dendritic atrophy and decreased spine density in neurons of the medial prefrontal cortex (43) and the hippocampus (44)(45)(46).…”

Section: Discussionmentioning

confidence: 99%

Creatine Activity as a Neuromodulator in the Central Nervous System

2023

ARI

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Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and acts as a neuromodulator. Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies have reported that brain creatine content could be enhanced with creatine supplementation. Nevertheless, there is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective effects of creatine on various mental aspects, such as cognition, memory skills, and spatial memory. The present review aimed to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, first, creatine and its potential influence on cognitive health and performance were briefly reviewed. Next, the existing experimental and clinical evidence was specifically explored to understand how creatine could interact as a neurotransmitter in the nervous system. Studies have revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with the N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies that creatine can be considered a neuromodulator.

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Laterality dissociation of ventral hippocampus inhibition in learning and memory, glial activation and neural arborization in response to chronic stress in male Wistar rats

Cited by 2 publications

References 54 publications

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Creatine Activity as a Neuromodulator in the Central Nervous System

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