Lateralisation of subcortical functional connectivity during and after general anaesthesia

Nir, Tommer; Raizman, Reut; Meningher, Inbar; Jacob, Yael; Huang, Kuang-Han; Schwartz, Arthur E.; Brallier, Jess W.; Ahn, Helen; Kundu, Prantik; Tang, Cheuk Y.; Delman, Bradley N.; McCormick, Patrick J.; Scarpa, Julia; Sano, Mary; Deiner, Stacie; Livny, Abigail; Baxter, Mark G.; Mincer, Joshua S.

doi:10.1016/j.bja.2021.08.033

Cited by 6 publications

(6 citation statements)

References 56 publications

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“…Homotopic interhemispheric rsFC can be extensively reduced by traumatic brain injury (Li et al ., 2017a ; Mäki-Marttunen et al ., 2013 ; Ovadia-Caro et al ., 2012 ; Raizman et al ., 2022 ; Song et al ., 2022 ) and predict the degree of consciousness or coma severity in disorders of consciousness (Mäki-Marttunen et al ., 2013 ; Ovadia-Caro et al ., 2012 ). Both animal model (Bukhari et al ., 2018 ) and human (Nir et al ., 2022 ) studies have also reported that loss of consciousness produced by general anesthesia reduces the strength of homotopic interhemispheric rsFC and correspondingly increases hemispheric lateralization.…”

Section: Vmhc Methodology and Functional Importance Of Homotopic Inte...mentioning

confidence: 98%

Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features

Yao

Kendrick

2022

Psychoradiology

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There is considerable interest in the significance of structural and functional connections between the two brain hemispheres both in terms of normal function and in relation to psychiatric disorders. In recent years many studies have used voxel mirrored homotopic connectivity (VMHC) analysis of resting state data to investigate the importance of connectivity between homotopic regions in the brain hemispheres in a range of neuropsychiatric disorders. The current review summarizes findings from these VMHC studies in individuals with autism spectrum disorder, addiction, attention deficit hyperactivity disorder, anxiety and depression disorders and schizophrenia as well as disorders such as Alzheimer's disease, mild cognitive impairment, epilepsy and insomnia. Overall, other than attention deficit hyperactivity disorder, studies across psychiatric disorders report decreased homotopic resting state functional connectivity in the default mode network, attention, salience, sensorimotor, social cognition, visual recognition, primary visual processing and reward networks, which are often associated with symptom severity and/or illness onset/duration. Decreased homotopic resting state functional connectivity may therefore represent a transdiagnostic marker for general psychopathology. In terms of disorder specificity, the extensive decreases in homotopic resting state functional connectivity in autism differ markedly from attention deficit hyperactivity disorder despite both occurring during early childhood and showing extensive co-morbidity. A pattern of more posterior than anterior regions showing reductions in schizophrenia is also distinctive. Going forward more studies are needed to elucidate the functions of these homotopic functional connections in both health and disorder and focusing on associations with general psychopathology not only on disorder specific symptoms.

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Section: Vmhc Methodology and Functional Importance Of Homotopic Inte...mentioning

confidence: 98%

Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features

Yao

Kendrick

2022

Psychoradiology

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“…The sensitive SNPs associated with sedative and cardiovascular effects of sevoflurane are not identical, possibly due to the different mechanisms by which sevoflurane exerts these 2 effects. Sevoflurane acts on multiple parts of the central nervous system, including the reticular ascending activation system in the brain, the thalamus, and so on, to exert a sedative effect 27,28 . However, the main centers that control cardiovascular activity are the spinal cord and brain stem.…”

Section: Discussionmentioning

confidence: 99%

“…Sevoflurane acts on multiple parts of the central nervous system, including the reticular ascending activation system in the brain, the thalamus, and so on, to exert a sedative effect. 27,28 However, the main centers that control cardiovascular activity are the spinal cord and brain stem.…”

Section: Discussionmentioning

confidence: 99%

Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane

Zhao

Huang

Zhong

et al. 2022

The Journal of Clinical Pharma

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The susceptibility of different individuals to anesthetics varies widely, and sevoflurane is no exception. We hypothesized that polymorphisms in genes involved in pharmacokinetics and pharmacodynamics may explain this variation. A total of 151 individuals undergoing otorhinolaryngology surgery were included. The influence of genetic polymorphisms on sevoflurane sensitivity were investigated through SNaPshot technology. Individuals carrying KCNK2 rs6686529 G > C, MTRR rs3733784 TT, rs2307116 GG, or rs1801394 AA polymorphisms had a higher sensitivity to the sedative effect of sevoflurane than those without those polymorphisms. The univariate linear regression analysis indicated that MTRR rs3733784 TT, rs2307116 GG, and rs1801394 AA were potentially significant predictors of higher sensitivity to the sedative effect of sevoflurane. Moreover, CYP2E1 rs3813867 G > C and rs2031920 C > T, GABRG1 rs279858 T > C, KCNK3 rs1275988 CC, GRIN2B rs1806201 GG, MTRR rs2307116 G > A, and rs1801394 A > G were associated with a higher sensitivity to the cardiovascular effect of sevoflurane. Our results suggested that 9 single nucleotide polymorphisms in genes involved in metabolizing enzymes, transport proteins, target proteins of sevoflurane and folate metabolism may help to explain individual differences in the susceptibility to the sedative or cardiovascular effect of sevoflurane.

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“…Previous studies suggested the critical roles of the thalamus system in regulation of GA. 1 , 4 , 5 The functional connectivity of thalamocortical networks was considered as an essential regulator of consciousness loss mediated by GA. 4 , 5 , 6 , 7 , 8 Numerous studies showed that thalamocortical functional connectivity was disrupted during GA‐induced unconsciousness in animals and humans. 9 , 10 , 11 , 12 , 13 Moreover, multiple nuclei in the thalamus, such as the paraventricular thalamus (PVT), the central medial thalamic nucleus (CMT) and their related neural circuits, have been reported to play important roles in the regulation of states of consciousness during GA, especially the recovery period after GA. 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 A recent study also revealed that the ventral posteromedial nucleus (VPM) of the thalamus actively promoted arousal of GA, which is independent of the process of anesthesia. 22 These findings suggested the importance of the thalamus in the recovery of consciousness after GA.…”

Section: Introductionmentioning

confidence: 99%

GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol‐ and isoflurane‐mediated general anesthesia

Yi,

Chen,

Zhong

et al. 2024

CNS Neurosci Ther

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BackgroundThe thalamus system plays critical roles in the regulation of reversible unconsciousness induced by general anesthetics, especially the arousal stage of general anesthesia (GA). But the function of thalamus in GA‐induced loss of consciousness (LOC) is little known. The thalamic reticular nucleus (TRN) is the only GABAergic neurons‐composed nucleus in the thalamus, which is composed of parvalbumin (PV) and somatostatin (SST)‐expressing GABAergic neurons. The anterior sector of TRN (aTRN) is indicated to participate in the induction of anesthesia, but the roles remain unclear. This study aimed to reveal the role of the aTRN in propofol and isoflurane anesthesia.MethodsWe first set up c‐Fos straining to monitor the activity variation of aTRNPV and aTRNSST neurons during propofol and isoflurane anesthesia. Subsequently, optogenetic tools were utilized to activate aTRNPV and aTRNSST neurons to elucidate the roles of aTRNPV and aTRNSST neurons in propofol and isoflurane anesthesia. Electroencephalogram (EEG) recordings and behavioral tests were recorded and analyzed. Lastly, chemogenetic activation of the aTRNPV neurons was applied to confirm the function of the aTRN neurons in propofol and isoflurane anesthesia.Resultsc‐Fos straining showed that both aTRNPV and aTRNSST neurons are activated during the LOC period of propofol and isoflurane anesthesia. Optogenetic activation of aTRNPV and aTRNSST neurons promoted isoflurane induction and delayed the recovery of consciousness (ROC) after propofol and isoflurane anesthesia, meanwhile chemogenetic activation of the aTRNPV neurons displayed the similar effects. Moreover, optogenetic and chemogenetic activation of the aTRN neurons resulted in the accumulated burst suppression ratio (BSR) during propofol and isoflurane GA, although they represented different effects on the power distribution of EEG frequency.ConclusionOur findings reveal that the aTRN GABAergic neurons play a critical role in promoting the induction of propofol‐ and isoflurane‐mediated GA.

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Lateralisation of subcortical functional connectivity during and after general anaesthesia

Cited by 6 publications

References 56 publications

Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features

Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features

Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane

GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol‐ and isoflurane‐mediated general anesthesia

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