Lateral trapping of DNA inside a voltage gated nanopore

Töws, Thomas; Reimann, Peter

doi:10.1103/physreve.95.062413

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Motivated by the concept and design of metal-oxidesemiconductor FET, an additional control gate near/around the nanopore can be introduced to manage the analyte movement. Simulation based on electrokinetics shows that the translocation dynamics of DNA strands, including capture rate and translocation speed, can be controlled by applying a bias voltage on the gate electrode around the nanopore [83,289]. A direct effect of the gate voltage is control of the surface potential, and thus the surface charge density, of the nanopore sidewall.…”

Section: Novel Signal Readout Methodsmentioning

confidence: 99%

Fundamentals and potentials of solid-state nanopores: a review

Wen

Zhang

2020

J. Phys. D: Appl. Phys.

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Solid-state nanopore (SSNP) technology presents an emerging single-molecule based analytical tool for separation and analysis of biomolecules or nanoparticles. Different prominent approaches have been pursued to attain the anticipated detection performance: process innovation to achieve pore size matching the physical dimensions of biomolecules so as to boost signal; electrolyte management to control translocation speed so as to improve signal quality; surface functionalisation to amplify molecular differences so as to enhance specificity; and implementation of additional, complementary means, such as optical, to manipulate the translocation so as to increase data fidelity. This review focuses on the fundamentals pertaining to the physical processes involved in nanopore sensing based on SSNPs of distinct shapes. It also provides a comprehensive picture regarding challenges and development trends in putting nanopore-based molecular sensors in use. This effort is facilitated by establishing physical-phenomenological models supported by experiment and numerical simulation. To assist the readership, the discussion starts from relatively simple cases and then develops towards complex systems, i.e. from open-pore state to analyte translocation and from single pores to pore arrays. Key physical parameter threading through these aspects is effective transport length that is simple to perceive and easy to calculate.

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Section: Novel Signal Readout Methodsmentioning

confidence: 99%

Fundamentals and potentials of solid-state nanopores: a review

Wen

Zhang

2020

J. Phys. D: Appl. Phys.

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“…Continuum electrostatic and hydrodynamic models [17] are used extensively to investigate the factors controlling nanoparticles or DNA (represented by a rod shaped object) translocation through a pore along its central axis [18][19][20][21]. Such models allowed to identify the interactions under certain conditions for the applied potential bias, membrane charge, and electrolyte concentration.…”

Section: Introductionmentioning

confidence: 99%

Brownian dynamics simulations of the ionic current traces for a neutral nanoparticle translocating through a nanopore

Hulings

Melnikov²,

Gracheva³

2018

Nanotechnology

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In this work, the ionic current blockades due to the translocation of a neutral spherical nanoparticle through a nanopore in a solid state membrane are computed. We use a Brownian dynamics approach, in conjunction with a full three-dimensional self-consistent solution of the Poisson-Nernst-Planck and Navier-Stockes system of equations to describe realistic ionic current response arising due to the random motion of a nanoparticle through a nanopore. We find that in addition to the usual geometric blockade, the variations of the current along the axis of the pore are largely caused by a concentration polarization induced by the presence of the translocating nanoparticle in the nanopore while the current changes in the radial (perpendicular to the axis) direction occur because of the local build up of the ionic charge between the particle and the nanopore surface. By performing statistical analysis of the current traces, we also observe that, in general, smaller current blockade values correspond to faster translocation times, while increased dwell times result in a larger current decrease.

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Self-consistent Brownian Dynamics Simulations of the Ionic Current Blockade in Solid State Nanopores

Melnikov,

Gracheva

2023

Nanostructure Science and Technology

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Lateral trapping of DNA inside a voltage gated nanopore

Cited by 3 publications

References 48 publications

Fundamentals and potentials of solid-state nanopores: a review

Fundamentals and potentials of solid-state nanopores: a review

Brownian dynamics simulations of the ionic current traces for a neutral nanoparticle translocating through a nanopore

Self-consistent Brownian Dynamics Simulations of the Ionic Current Blockade in Solid State Nanopores

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