Lateral Thinking: How Histone Modifications Regulate Gene Expression

Lawrence, Moyra; Daujat, Sylvain; Schneider, Robert

doi:10.1016/j.tig.2015.10.007

Cited by 708 publications

(526 citation statements)

References 337 publications

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“…Generally speaking, marks such as H3K4me3, H3K9ac and H3K27ac denote regions of active gene expression, and marks such as H3K9me2/3 and H3K27me3 denote regions of transcriptional repression (for review see refs. 27,28). Among the many known repressive epigenetic modifiers, the Ehmt1/2 complex plays a central part in establishing repressive epigenetic marks.…”

Section: The Ehmt1/2 Complexmentioning

confidence: 99%

The expanding role of the Ehmt2/G9a complex in neurodevelopment

2017

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Epigenetic regulators play a crucial role in neurodevelopment. One such epigenetic complex, Ehmt1/2 (G9a/GLP), is essential for repressing gene transcription by methylating H3K9 in a highly tissue-and temporal-specific manner. Recently, data has emerged suggesting that this complex plays additional roles in regulating the activity of numerous other non-histone proteins. While much is known about the downstream effects of Ehmt1/2 function, evidence is only beginning to come to light suggesting the control of Ehmt1/2 function may be, at least in part, due to context-dependent binding partners. Here we review emerging roles for the Ehmt1/2 complex suggesting that it may play a much larger role than previously recognized, and discuss binding partners that we and others have recently characterized which act to coordinate its activity during early neurodevelopment.

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Section: The Ehmt1/2 Complexmentioning

confidence: 99%

The expanding role of the Ehmt2/G9a complex in neurodevelopment

2017

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“…Information other than that on the genetic level has been found to be related to a variety of biological phenomena such as gene expression and cell differentiation [20][21][22][23][24][25][26][27][28]. Histone modifications and replacements belong to such mechanisms [25,26,[29][30][31][32][33][34][35][36][37][38][39].…”

Section: Modification and Replacement For Histonesmentioning

confidence: 99%

“…Histone modifications and replacements belong to such mechanisms [25,26,[29][30][31][32][33][34][35][36][37][38][39]. A chromosome is formed from chromatin, which is modelled from histones and DNA [40,41].…”

Section: Modification and Replacement For Histonesmentioning

confidence: 99%

Epigenetics and Codon Usage of the Histone Genes in 12 Drosophila Species

Matsuo¹

2017

J Phylogenetics Evol Biol

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Histones are proteins that bind to DNA and form nucleosomes. There are several types of histones that differ in chromosome distribution and timing of their expression. In Drosophila, each canonical type histone is identical or highly similar in amino acid sequence to its corresponding replacement type histone; however, gene structure and codon usage differ between the two types of histones. Identification of the evolutionary changes responsible for the differences between these two histone types will lead to an understanding of the development of epigenetic regulation. Here, recent findings regarding codon usage for canonical and replacement types of histones are outlined for study of the evolution of these histone genes and their epigenetic regulation in Drosophila.

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“…Current research work has shown DNA repair, replication, stemness and alteration in cell state are influenced as well by histone core modifications. In addition, histone modifications are directly regulating transcription (Lawrence et al, 2016).…”

Section: Histone Modification and Chromatin Remodellingmentioning

confidence: 99%

Pesticide Exposures Induce Male-Mediated Reproductive Toxicity: A Review

Yusoff¹,

Budin²,

Taib³

2017

JAS

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Infertility remains a continuing globally problem wherever couples worldwide were infertile as much as 42 million in 1990 and keep projecting to 48.5 million in 2010. Male-mediated infertility becomes one of the numerous concerns due to pesticide especially sperm quality as revealed with raising number of animal and human studies in latter-day among researchers. Pesticides have been used since the early days as pest control in agriculture, as vector controls in malaria and dengue as well as subject to much regulation. The reproductive system might be affected with some negative effects from pesticides that lead to interference with the male hormonal function. Polyunsaturated fatty acid (PUFA) content in the sperm cell membrane makes it become highly susceptible towards reactive oxygen species (ROS), thus leading to sperm damage. Besides known genetic and environmental factors, research during the last two decades has highlight on several mechanisms and their association with male infertility. The male germ line undergoes extensive epigenetic modifications throughout fetal to adult life hence vulnerable to environmental factors that may influence fertility. The present literature will help in understanding the mechanisms of pesticide in inducing male-mediated reproductive toxicity.

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Lateral Thinking: How Histone Modifications Regulate Gene Expression

Cited by 708 publications

References 337 publications

The expanding role of the Ehmt2/G9a complex in neurodevelopment

The expanding role of the Ehmt2/G9a complex in neurodevelopment

Epigenetics and Codon Usage of the Histone Genes in 12 Drosophila Species

Pesticide Exposures Induce Male-Mediated Reproductive Toxicity: A Review

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