Lateral Tarsorrhaphy

Panda, Anita; Pushker, Neelam; Bageshwar, Lalit M. S.

doi:10.1097/00003226-199905000-00010

Cited by 28 publications

(1 citation statement)

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“…Sometimes, corneal wounds persist over time and are resistant to conventional treatment, such as artificial tears or topical antibiotics [4], lateral tarsorrhaphy [5], bandage contact lenses [6], punctual plugs [7], and amniotic membrane transplantation [8]. Different topical growth factors have been also tested in these persistent epithelial defects [9,10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects

Suárez-Barrio

Etxebarría

Hernáez‐Moya

et al. 2019

IJMS

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The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a blood derivative that has already shown efficacy in corneal epithelial wound healing), to reduce time of healing or posology. In vitro proliferation and migration studies, both in human corneal epithelial (HCE) cells and in rabbit primary corneal epithelial (RPCE) cultures, were carried out. In addition, we performed studies of corneal wound healing in vivo in rabbits treated with s-PRGF, NaHA, or the combination of both. We performed immunohistochemistry techniques (CK3, CK15, Ki67, ß4 integrin, ZO-1, α-SMA) in rabbit corneas 7 and 30 days after a surgically induced epithelial defect. In vitro results show that the combination of NaHA and s-PRGF offers the worst proliferation rates in both HCE and RPCE cells. Addition of NaHA to s-PRGF diminishes the re-epithelializing capability of s-PRGF. In vivo, all treatments, given twice a day, showed equivalent efficacy in corneal epithelial healing. We conclude that the combined use of s-PRGF and HaNA as an adhesive biopolymer does not improve the efficacy of s-PRGF alone in the wound healing of corneal epithelial defects.

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