Lateral ridge augmentation using particulated or block bone substitutes biocoated with rhGDF-5 and rhBMP-2: an immunohistochemical study in dogs

Abstract

Within the limits of the present study, it was concluded that both rhGDF-5 and rhBMP-2 have shown efficacy; however, their bone regenerative effect was markedly influenced by the carrier.

Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs

“…Such observations might result from the different biodegradation patterns of particulated and block-type biomaterials. Some previous studies [28,29] found less biodegradation and bone formation with block bone grafts in lateral or calvarial defects. In calvarial defects that received particulated bone, new bone formation occurred on the surface of individual particles of biomaterials, and grew into the spaces between them over a longer healing period.…”

The effect of two point mutations in GDF-5 on ectopic bone formation in a β-tricalciumphosphate scaffold

“…BMP-2 and GDF-5 have been compared regarding their angiogenic and osteogenic capacity in the past [32][33][34][35]: in vitro GDF-5 not only promoted osteogenic differention of fat derived MSC but, in contrast to BMP-2, also increased vascular endothelial growth factor gene expression [35]. While the angiogenic capacity of GDF-5 was superior to BMP-2 in chick chorioallantoic membrane and rabbit cornea assays [34], the in vivo osteogenic activity of BMP-2 was higher than that of GDF-5 in calvarial defects of rats [33].…”

Tissue engineering for bone regeneration and osseointegration in the oral cavity

“…GDF-5 has also been used in mini-pig sinus augmentation, where it enhanced bone formation with a β-TCP carrier [120, 121]. In lateral ridge augmentation with a coated Bio-Oss ® block, GDF-5 resulted in increased mineralized tissue formation [122]. …”