Lateral Lymph Node Metastasis in Papillary Thyroid Carcinoma: Results of Therapeutic Lymph Node Dissection

Chung, Yoo Seung; Kim, Jee Young; Bae, Ja Seong; Song, Byung-Joo; Kim, Jeong Soo; Jeon, Hae Myung; Jeong, Sang-Seol; Kim, Eung Kook; Park, Woo-Chan

doi:10.1089/thy.2008.0244

Cited by 116 publications

(133 citation statements)

References 35 publications

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“…Extrathyroidal invasion (16), multifocality (17) and bilateral thyroid tumors of PTMC (18) are the important risk factors in lymph node metastasis that represent biological characteristics of progress. Although the study by McCarthy et al (19) reported that multifocality is highly homologous within the gland and is not associated with tumor invasion, Shindo et al (17) and Chow et al (20) found that neck lymph node metastasis and tumor multifocality remain significantly correlated, which is the major reason for lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Zhang

Wei

et al. 2015

Molecular and Clinical Oncology

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Abstract. The present study examines the requirement of prophylactic neck node dissection in papillary thyroid microcarcinoma (PTMC) patients by analyzing high-risk factors of neck lymph node metastasis in PTMC. The clinical pathological data was a review of 1,990 patients diagnosed between January 2013 and January 2014. The data included information on patient gender, age, tumor size, multifocal, tumor pathological staging, bilateral thyroid cancer, the subtypes, BRAF V600E mutation, human telomerase reverse transcriptase (hTERT), extrathyroidal invasion and neck lymph node metastasis. The univariate analysis (χ 2 test) showed that a number of factors were significantly associated with neck lymph node metastasis in PTMC (P<0.05): Male gender, aged <45 years, extrathyroidal invasion, bilateral thyroid cancer, various subtypes (package type, follicular variant, diffuse sclerosing variant, eosinophils, tall cell and column variant), BRAF V600E mutation-positive, hTERT mutation-positive, pt3/4 and multifocality. The multivariate analysis (regression binary logistic) showed that the male gender, <45 years, tumor size >5 mm, extrathyroidal invasion, bilateral thyroid tumors, multifocality, BRAF V600E mutation-positive, hTERT mutation-positive and pt3/4 are associated with the neck lymph node metastasis in PTMC (P<0.05). These paired analysis results show that the subtypes of PTMC with tumor size >5 mm is more common than the specific types of PTMC in which the tumor is ≤5 mm in neck lymph node metastasis. The neck lymph node metastasis incidence of the >45 years age group patients without high-risk factors in PTMC is 8.13 and 6.80%, respectively. In conclusion, PTMC patients with high-risk factors only are recommended to undergo a prophylactic lymph node dissection.

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Section: Discussionmentioning

confidence: 99%

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Zhang

Wei

et al. 2015

Molecular and Clinical Oncology

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“…Lymph node metastases are regarded as prognostic factor of PTC patient's survival. There are some reports demonstrating higher frequency of nodal involvement in younger patients, whereas other point out the nodal involvement and patient's age $45 as factors affecting survival in patients with papillary thyroid carcinoma [40,41]. We found that PDPN neoexpression is strongly correlated with older ($45) patients age, which is one of the several classical clinico-pathological highrisk factors in papillary thyroid carcinomas.…”

Section: Discussionmentioning

confidence: 46%

The role of podoplanin in the biology of differentiated thyroid cancers

Karpińska¹,

Rudzińska²,

Gawel³

et al. 2014

EJEA

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Podoplanin (PDPN), a mucin-type transmembrane glycoprotein specific to the lymphatic system is expressed in a variety of human cancers, and is regarded as a factor promoting tumor progression. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells. PDPN expression was evaluated in primary thyroid carcinomas and thyroid carcinoma cell lines by RT-qPCR, Western blotting, IF and IHC. To examine the role of podoplanin in determining a cell's malignant potential (cellular migration, invasion, proliferation, adhesion, motility, apoptosis), a thyroid cancer cell line with silenced PDPN expression was used. We observed that PDPN was solely expressed in the cancer cells of 40% of papillary thyroid carcinoma (PTC) tissues. Moreover, PDPN mRNA and protein were highly expressed in PTC-derived TPC1 and BcPAP cell lines but were not detected in follicular thyroid cancer derived cell lines. PDPN knock-down significantly decreased cellular invasion, and modestly reduced cell migration, while proliferation and adhesion were not affected. Our results demonstrate that PDPN mediates the invasive properties of cells derived from papillary thyroid carcinomas, suggesting that podoplanin might promote PTC progression.

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“…Mercante et al [2009], in their large study of 445 cases demonstrated that age was not a significant risk factor for neck recurrence or distant metastasis. Another study reported that patients with lymph node metastasis were younger than those without lymph node metastases [Chung et al, 2009]. Y.…”

Section: Age In Ptmcmentioning

confidence: 99%

“…PTMCs also showed a high incidence of regional lymph node metastasis, occurring in 12--64% of patients [Besic et al, 2008;Choi et al, 2008;Chung et al, 2009;J. Lee et al, 2006;Y.…”

Section: Ptmc In the Staging Systemsmentioning

confidence: 99%

Papillary Thyroid Microcarcinoma - Do Classical Staging Systems Need to Be Changed?

Zafón¹

2012

Thyroid and Parathyroid Diseases - New Insights Into Some Old and Some New Issues

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Lateral Lymph Node Metastasis in Papillary Thyroid Carcinoma: Results of Therapeutic Lymph Node Dissection

Cited by 116 publications

References 35 publications

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

The role of podoplanin in the biology of differentiated thyroid cancers

Papillary Thyroid Microcarcinoma - Do Classical Staging Systems Need to Be Changed?

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