Lateral inhibition and habituation of the human auditory cortex

Pantev, Christo; Okamoto, Hidehiko; Roß, Bernhard; Stoll, Wolfgang; Ciurlia-Guy, E.; Kakigi, Ryusuke; Kubo, Takeshi

doi:10.1111/j.0953-816x.2004.03296.x

Cited by 77 publications

(84 citation statements)

References 21 publications

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“…Our target notched music introduced a functional deafferentation of auditory neurons corresponding to the eliminated frequency band, and because this frequency band overlapped the individual tinnitus frequency, the notched music no longer stimulated the cortical area corresponding to the tinnitus frequency, although it still excited surrounding neurons. Thus, the neurons, which were not stimulated due to the notch, were presumably actively suppressed via lateral inhibitory inputs originating from surrounding neurons (14,31,32). Alternatively, listening to the target notched music could have induced synaptic and/or cellular plasticity mechanisms (33,34).…”

Section: Discussionmentioning

confidence: 99%

“…For ASSR analysis, the grand-averaged magnetic field signals within the time range from 0.5 to 1 s were used for single equivalent current dipole estimations (43), and the maximal source strength for each condition and hemisphere was calculated by using the source space projection technique (44). For the N1m analysis, the grand-averaged magnetic fields were 30 Hz low-pass filtered and baseline corrected (31,32,45). Thereafter, the maximal source strength for each condition was calculated in a manner similar to the ASSR source strength calculation.…”

Section: Methodsmentioning

confidence: 99%

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Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Okamoto¹,

Stracke²,

Stoll

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

232

206

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Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus patients to self-chosen, enjoyable music, which was modified ("notched") to contain no energy in the frequency range surrounding the individual tinnitus frequency. After 12 months of regular listening, the target patient group (n = 8) showed significantly reduced subjective tinnitus loudness and concomitantly exhibited reduced evoked activity in auditory cortex areas corresponding to the tinnitus frequency compared to patients who had received an analogous placebo notched music treatment (n = 8). These findings indicate that tinnitus loudness can be significantly diminished by an enjoyable, low-cost, customtailored notched music treatment, potentially via reversing maladaptive auditory cortex reorganization.cortical plasticity | human auditory cortex | lateral inhibition | magnetoencephalography | MEG S ubjective tinnitus (1) is among the most prevalent symptoms of hearing disorders in industrialized countries (2, 3). Tinnitus loudness can be considered as the most tangible tinnitus characteristic. In 1-3% of the general population, the tinnitus sensation is loud enough to affect the quality of life (4). Causal treatment strategies for tinnitus are not yet available.The lack of treatment strategies is due to incomplete knowledge concerning the mechanisms of tinnitus generation and maintenance. However, recent neurophysiological studies have shown that tinnitus is presumably caused by maladaptive auditory cortex reorganization (4-6) (similar phenomena were observed also in somatosensory cortex; refs. 7-9). For instance, magnetoencephalography (MEG) studies have demonstrated that auditory cortical map areas corresponding to the tinnitus frequency were distorted; the amount of distortion correlated positively with perceived tinnitus strength (10). Moreover, auditory cortex activity corresponding to the tinnitus frequency was shown to be enhanced and related to perceived tinnitus intrusiveness (11).To date, widely used tinnitus treatment strategies (e.g., tinnitus retraining therapy; ref. 12) are merely symptom management approaches. Therefore, there is a great demand for causal treatment approaches targeting the tinnitus percept more directly. Recent neurophysiological studies indicate that behavioral training can be a powerful means to reverse maladaptive cortical reorganization (7, 13).A previous study (14) demonstrated that listening to spectrally "notched" music can reduce cortical activity corresponding to the notch center frequency, possibly through lateral inhibition. Motivated by this finding, we developed an innovative tinnitus treatment strategy aimed at reducing tinnitus loudness. The treatment regimen consists of regular listening to enjoyable, custom-tailored notched music. Here, we evaluate and report results of the treatment from a longitudinal double-blinded ...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Okamoto¹,

Stracke²,

Stoll

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

232

206

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the classical lateral inhibition concept (von Békésy, 1967; Suga, 1995; Pantev et al, 2004;Okamoto et al, 2005Okamoto et al, , 2007 can account for sharpening of frequency tuning in the central auditory system. Afferent neural inputs consist not only of excitatory, but also of broadly tuned inhibitory inputs, which suppress surrounding neural activities resulting in improved spectral contrast.…”

Section: Discussionmentioning

confidence: 99%

Attention Improves Population-Level Frequency Tuning in Human Auditory Cortex

Okamoto¹,

Stracke²,

Wolters³

et al. 2007

J. Neurosci.

Self Cite

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Attention improves auditory performance in noisy environments by either enhancing the processing of task-relevant stimuli ("gain"), suppressing task-irrelevant information ("sharpening"), or both. In the present study, we investigated the effect of focused auditory attention on the population-level frequency tuning in human auditory cortex by means of magnetoencephalography. Using complex stimuli consisting of a test tone superimposed on different band-eliminated noises during active listening or distracted listening conditions, we observed that focused auditory attention caused not only gain, but also sharpening of frequency tuning in human auditory cortex as reflected by the N1m auditory evoked response. This combination of gain and sharpening in the auditory cortex may contribute to better auditory performance during focused auditory attention.

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“…Given that tonotopic representations are retained up to the level of the primary auditory cortex (Kaas & Hackett, 2000), it is likely that segregation of tone sequences in the cochlea is transferred up the ascending auditory system. Additional inhibitory processes between neurons responsive to different frequencies in the auditory cortex have been proposed to enhance frequency-based segregation (Bee & Klump, 2004;Fishman et al, 2004;Kanwal et al, 2003;McCabe & Denham, 1997), and recent evidence shows that inhibition operates on the N1 (Pantev et al, 2004;Sable, Low, Maclin, Fabiani, & Gratton, 2004). Inhibition between neurons that are tuned to different frequencies in the auditory cortex might enhance frequency-based segregation by sharpening the tuning curves in individual neurons, thus leading to less overlap in the populations of neurons that are responding to the alternating A and B tones.…”

Section: Evidence For Distinct Mechanisms Of Stream Segregationmentioning

confidence: 99%

Effects of Attention on Neuroelectric Correlates of Auditory Stream Segregation

Snyder

Alain

Picton

2006

Journal of Cognitive Neuroscience

266

292

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Abstract& A general assumption underlying auditory scene analysis is that the initial grouping of acoustic elements is independent of attention. The effects of attention on auditory stream segregation were investigated by recording event-related potentials (ERPs) while participants either attended to sound stimuli and indicated whether they heard one or two streams or watched a muted movie. The stimuli were pure-tone ABAÀ patterns that repeated for 10.8 sec with a stimulus onset asynchrony between A and B tones of 100 msec in which the A tone was fixed at 500 Hz, the B tone could be 500, 625, 750, or 1000 Hz, and À was a silence. In both listening conditions, an enhancement of the auditory-evoked response (P1-N1-P2 and N1c) to the B tone varied with Áf and correlated with perception of streaming. The ERP from 150 to 250 msec after the beginning of the repeating ABAÀ patterns became more positive during the course of the trial and was diminished when participants ignored the tones, consistent with behavioral studies indicating that streaming takes several seconds to build up. The N1c enhancement and the buildup over time were larger at right than left temporal electrodes, suggesting a right-hemisphere dominance for stream segregation. Sources in Heschl's gyrus accounted for the ERP modulations related to Áf-based segregation and buildup. These findings provide evidence for two cortical mechanisms of streaming: automatic segregation of sounds and attention-dependent buildup process that integrates successive tones within streams over several seconds. &

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Lateral inhibition and habituation of the human auditory cortex

Cited by 77 publications

References 21 publications

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

Attention Improves Population-Level Frequency Tuning in Human Auditory Cortex

Effects of Attention on Neuroelectric Correlates of Auditory Stream Segregation

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