2010
DOI: 10.1039/c0cc02782k
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Lateral flow nucleic acid biosensor for Cu2+ detection in aqueous solution with high sensitivity and selectivity

Abstract: A lateral flow nucleic acid biosensor based on copper-dependent DNA-cleaving DNAzyme and gold nanoparticles has been developed for the visual detection of copper ions (Cu(2+)) in an aqueous solution with a detection limit of 10 nM.

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Cited by 109 publications
(46 citation statements)
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“…Liu et al, 2014;C. Liu et al, 2014) and metallic cations (Mazumdar et al, 2010;Torabi and Lu, 2011;Kuang et al, 2013;López-Marzo et al, 2013aFang et al, 2010) also can be detected using several strategies. In the case of the work of Fang et al (2010), Cu 2 þ ions can be detected taking advantage of the cleavage that cooper causes, in presence of ascorbate, on Cu 2 þ -specific-DNAzymes (linked to AuNPs) which, if broken, will be captured on TL.…”
Section: Designed a Lfsmentioning
confidence: 97%
“…Liu et al, 2014;C. Liu et al, 2014) and metallic cations (Mazumdar et al, 2010;Torabi and Lu, 2011;Kuang et al, 2013;López-Marzo et al, 2013aFang et al, 2010) also can be detected using several strategies. In the case of the work of Fang et al (2010), Cu 2 þ ions can be detected taking advantage of the cleavage that cooper causes, in presence of ascorbate, on Cu 2 þ -specific-DNAzymes (linked to AuNPs) which, if broken, will be captured on TL.…”
Section: Designed a Lfsmentioning
confidence: 97%
“…Zeng and coworkers utilized Cu 2+ - and Pb 2+ -dependent DNAzymes to fabricate a similar lateral flow device for the detection of Cu 2+ (Figure 8B) and Pb 2+ , respectively. 158,159 The introduction of a catalytic DNA circuit in the Pb 2+ -sensitive device dramatically enhanced the sensitivity of the sensor when compared with previous solution-based approaches. 159 …”
Section: Metal Ion-dependent Dnazymes For Metal Ion Recognitionmentioning
confidence: 99%
“…In the absence of Cu 2+ , however, no release of the ssDNA occurred, thus the AuNPs moved across the test line and were captured on the control line where complementary DNA was immobilized. Therefore, a red line appeared on the test line only when Cu 2+ was present in the samples [255]. Later, the same research group further incorporated a catalytic DNA circuit that could amplify the release of a ssDNA by the 8-17 DNAzyme and its substrate, achieving the detection of Pb 2+ on a lateral-flow device with high sensitivity [277].…”
Section: Nucleic Acid Cleaving/ligating Dnazymes and Aunps For Biosenmentioning
confidence: 98%