Lateral displacement of the nipples, a sign of bilateral renal hypoplasia

Fleisher, Daniel S.

doi:10.1016/s0022-3476(66)80129-4

Cited by 24 publications

(11 citation statements)

References 4 publications

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“…Normal ratio values from a healthy control group with no renal and/or gonadal disorders were 0.656, SD 0.11 (statistical analysis assessed by Student's /-test). These values are consistent with those of Fleisher [7]. On the contrary, the ratio of the affected patient revealed a value of 0.997 to be greater than 2 SD.…”

Section: Case Reportsupporting

confidence: 90%

“…There was no evidence of accessory nipples and breasts; the ears, face and testicles were normal. According to Fleisher [7] the determination of the location of the nipples is calculated by the following ratio: distance between ihe nipples (internipple distance) widlh of the chest between the anterior axillary lines (at the level of the nipples)…”

Section: Case Reportmentioning

confidence: 99%

“…In 1966 Fleisher described a series of seven infatits affected with bilateral renal hypoplasia and a partieularly wide set nipple pattern [7]. 1 his assoeiation was later regarded by Goeminne as •Fleisher syndrome' in an interesting review of the mammo-renal syndromes [8].…”

Section: Introductionmentioning

confidence: 99%

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Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆

Urbani

1995

Acad Dermatol Venereol

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Bacl^round of studyPolythelia is a cutaneous marker of congenital diseases of the kidneys. Lateral displacement of the nippies (e.g. laterally located to their respective midciavicular lines) is eonsidered a further sign of renal disorders, particularly of bilateral renal hypoplasia. as reported by Fleisher in a detailed study on seven infants.Subject We observed a 45-year-oId white man with his morphologically normal nipples displaced on the lateral aspeets of the trunk without any other consistent clitiical features such as aeeessory nipples or areolae, gonadal dysgenesis, face or ear anomalies.Aims and metbods In order to reveal congenital abnormalities of the kidneys and the urinary collecting systems the following investigations were undertaken: renal ultrasound, intravenous pyclography, abdomen CT and NMR scans, urethrocystography, transurethral eystoseopy, urinalysis, laboratory tests including karyotype, ECG and cardiovascular evaluation.Results Instrumental findings disclosed a hypoplastie left kidney in an ectopic site, loeated below the right kidney (cross type of renal ectopy) without any connection between their urinary eoilecting systems. Complex malformations of the urinary traet such as an orthotopic narrow right ureteral orifice and ridge, a large-sized divertieulum on the left wall of the bladder were also present. Moreover, a tumour on the upper pole of the right kidney, 20 mm in diameter, with a histologieal picture of renal-cell carcinoma was detected.Conclusions A lateral displacement of the nipples is a clue for the presence of renal hypoplasia both bilateral and unilateral. The significance of this association is unclear and its occurrence is probably underestimated. Prcsenled as an oral communicalion al the Ilird Congress of the European Academy of Dermatology and Venereology, " Corresponding auihor. Tci: ( + 34 2) 58187551. Fax; ( + 39 26-.30/9/1993. Copenhagen. Denmark. 2) 8321645; ( + 39 2) 58187.500. ()926-9959/95/$09.30 e 1995 Elsevier Science B.V. All rights reserved SSDI 0926-9959(94)00053-3

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Section: Case Reportsupporting

confidence: 90%

Section: Case Reportmentioning

confidence: 99%

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Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆

Urbani

1995

Acad Dermatol Venereol

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“…This relationship is mirrored in ‘mammorenal syndromes’ (26) supported by the ipsilateral presence of mammorenal lesions, as in 81% of patients of the series of Urbani and Betti [3], although the exact embryogenetic mechanisms remain unknown [27]. The clinical spectrum of mammorenal syndromes associated with chromosomal, dysmorphic genetic syndromes and acromammorenal ones [27, 28, 29]is increasing these days.…”

Section: Discussionmentioning

confidence: 99%

Is Aberrant Mammary Tissue a Marker for Chronic Alcoholism or Kidney-Urinary Tract Malformations?

1998

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Background: Numerous publications describe the relationship between aberrant mammary tissue (AMT) and kidney-urinary tract malformations, individual/ familial alcoholism and sense organ disorders. Patients and Methods: We investigated these possible associations and reviewed 72 cases observed in our Department during the past 3 years: 30 men and 42 women, 17 of them with bilateral AMT (7 men and 10 women) and 25 patients from 9 families. Diagnosis was made according to Kajawa’s classification. A detailed family history was performed asking for individual or familial alcoholism, especially in the mother, in addition to blood tests and ultrasonographic examination of the abdomen and the kidneys. Results: We only found 1 family history of alcoholism in 3 families, but in the father, never in the mother or the affected subject. No congenital/ hereditary nephrourinary defects or sense organ disorders were found. Conclusions: We believe that in our population AMT is not a marker for alcoholism, kidney-urinary malformations nor sense organ disorders.

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“…Clinical examination without quantita tive support led some authors to have the impression that widely spaced nipples were present in some syndromes such as Noonan, Turner, Edwards, and renal hypoplasia [Butler et al, 1965;Collins, 1973;Fleisher, 1966;Salgado et al. 1977].…”

mentioning

confidence: 99%

A Note on Quantitation of Intermammillary Distance

Freire‐Maia¹,

Pinheiro²,

Rapone-Gaidzinski³

et al. 1981

Hum Hered

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Lateral displacement of the nipples, a sign of bilateral renal hypoplasia

Cited by 24 publications

References 4 publications

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆

Is Aberrant Mammary Tissue a Marker for Chronic Alcoholism or Kidney-Urinary Tract Malformations?

A Note on Quantitation of Intermammillary Distance

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Lateral displacement of the nipples, a sign of bilateral renal hypoplasia

Cited by 24 publications

References 4 publications

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?⋆

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?⋆

Is Aberrant Mammary Tissue a Marker for Chronic Alcoholism or Kidney-Urinary Tract Malformations?

A Note on Quantitation of Intermammillary Distance

Contact Info

Product

Resources

About

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆

Lateral displacement of the nipples and unilateral renal hypoplasia: another mammo‐renal syndrome?^⋆