Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea

Pradhan, Rojalin; Kumar, Shubham; Mathew, Renjith

doi:10.1016/j.isci.2023.106380

Cited by 2 publications

(1 citation statement)

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“…In humans, errors in tube formation can result in congenital defects such as spina bifida and lung hypoplasia ( Wilde et al, 2014 ). Studies in both vertebrates and invertebrates have revealed key morphogenetic mechanisms underlying epithelial tube formation during development ( Andrew and Ewald, 2010 ; Chung et al, 2014 ; Herriges and Morrisey, 2014 ; Girdler and Röper, 2014 ; Nikolopoulou et al, 2017 ; Spina and Cowin, 2021 ; Pradhan et al, 2023 ). While proper cell shape changes and cell rearrangement are critical, precise regulation of cell division and cell death is also essential for tissue morphogenesis ( Huh et al, 2004 ; Mao et al, 2013 ; LeGoff and Lecuit, 2015 ; Godard and Heisenberg, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Coordination of cell cycle and morphogenesis during organ formation

Matthew,

Vishwakarma,

et al. 2024

eLife

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Organ formation requires precise regulation of cell cycle and morphogenetic events. Using the Drosophila embryonic salivary gland (SG) as a model, we uncover the role of the SP1/KLF transcription factor Huckebein (Hkb) in coordinating cell cycle regulation and morphogenesis. The hkb mutant SG exhibits defects in invagination positioning and organ size due to abnormal death of SG cells. Normal SG development involves distal-to-proximal progression of endoreplication (endocycle), whereas hkb mutant SG cells undergo abnormal cell division, leading to cell death. Hkb represses the expression of key cell cycle and pro-apoptotic genes in the SG. Knockdown of cyclin E or cyclin-dependent kinase 1, or overexpression of fizzy-related rescues most of the morphogenetic defects observed in the hkb mutant SG. These results indicate that Hkb plays a critical role in controlling endoreplication by regulating the transcription of key cell cycle effectors to ensure proper organ formation.

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