Latent tuberculosis infection, tuberculin skin test and vitamin D status in contacts of tuberculosis patients: a cross-sectional and case-control study

Arnedo-Pena, Alberto; Juan-Cerdán, J V; Romeu-Garcia, Angeles; García-Ferrer, Daniel; Holguín-Gómez, R; Iborra-Millet, Jesus; Herrero-Carot, Concepción; Piñana, María Jesús Sanchis; Bellido-Blasco, Juan B.; Ferrero-Vega, José Antonio; Adsuara, Lourdes Safont; Silvestre, Esther Silvestre; Ferrer, Noemi Meseguer; Bartual, Vicenta Rodrigo

doi:10.1186/1471-2334-11-349

Cited by 47 publications

(39 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Scientific research is studying the effect of vitamin D on the course of the TB disease. A recent study in Spain indicated that a high proportions of contacts of TB patients had low serum 25(OH)D levels and suggested that sufficient 25(OH)D levels protect against tuberculin skin test (TST) conversion, therefore supporting the hypothesis that deficient vitamin D status is a TB risk factor [44].…”

Section: Vitamin D Deficiency and Tbmentioning

confidence: 89%

The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

Dini

Bianchi

2012

Annali Dell'Istituto Superiore Di Sanità

View full text Add to dashboard Cite

Abstract.Introduction.Vitamin D deficiency (VDD) is a common condition among several populations in the world. VDD is associated with higher incidence of immune system disorders and faster progression of some infectious diseases. Vitamin D is known to be of physiological importance, it is considered an essential micronutrient for the bone health and plays a beneficial role in the prevention and/or treatment of a number of chronic diseases. Vitamin D has a complex action on the immune system. Results. Evidence that vitamin D protects against tuberculosis has been supported by in vitro, epidemiological and some preliminary clinical studies. Vitamin D has a potential effect on HIV (human immunodeficiency virus) and plays a crucial role in the defence against respiratory infections. Conclusions. Vitamin D supplementation could be a low-cost, practical method to protect groups of people with high incidence of those diseases. Public health education should stress the need for adequate dietary intake of vitamin D in those vulnerable groups.Key words: VDD, Vitamin D deficiency, tuberculosis, HIV, respiratory infections. Riassunto (Il ruolo potenziale della vitamina D nella prevenzione e terapia della tubercolosi e delle malattie infettive).Introduzione. La carenza di vitamina D è una condizione comune in numerosi gruppi di popolazione nel mondo. Essa risulta associata a un'elevata incidenza dei disturbi del sistema immunitario e a una più veloce progressione di alcune malattie infettive. Oltre ad essere un micronutriente essenziale per la salute dell'apparato scheletrico, la vitamina D riveste un ruolo importante nei processi fisiologici e nella prevenzione e/o terapia di numerose patologie croniche. Essa svolge un'azione complessa sul sistema immunitario. Risultati. La dimostrazione che la vitamina D protegge contro la tubercolosi è stata supportata da studi in vitro, epidemiologici e da alcuni dati clinici preliminari. La vitamina D ha un effetto potenziale sull'HIV (sindrome da immunodeficienza acquisita) e svolge un ruolo fondamentale nelle infezioni respiratorie. Conclusioni. La somministrazione di vitamina D può essere un metodo pratico, a basso costo per proteggere gruppi specifici di popolazione con elevata incidenza delle suddette malattie. L'educazione sanitaria pubblica dovrebbe mettere in risalto la necessità di una adeguata assunzione di vitamina D in tutti i gruppi vulnerabili.Parole chiave: carenza di vitamina D, tubercolosi, HIV, infezioni respiratorie.

show abstract

Section: Vitamin D Deficiency and Tbmentioning

confidence: 89%

The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

Dini

Bianchi

2012

Annali Dell'Istituto Superiore Di Sanità

View full text Add to dashboard Cite

show abstract

“…These include a clinical trial in Mongolian children on TBIC (14), a study of TB disease in Pakistan (4), and another study in Africa with HIV patients (15). In these studies, low VitD levels were associated with an increase of TB.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, all participants were interviewed about TB risk factors. A more detailed methodology has been reported in previous publications (15,16). For the participants, chemoprophylaxis against TB was recommended, taking into account exposure, age, clinical conditions, and the characteristics of the index TB case.…”

Section: Tuberculosis Diagnostic Testsmentioning

confidence: 99%

“…A cohort study of the contacts of pulmonary TB patients may allow for the quantification of the association of VitD status with TB disease, latent TB infection (LTBI), and TB infection conversion (TBIC), as we have already studied in recent publications (15)(16)(17). In addition, an analysis of this cohort as a whole may be useful to obtain measurements of the association of VitD with other potential factors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tuberculosis and Vitamin D Status Among the Contacts of Pulmonary Tuberculosis Patients

Arnedo-Pena¹,

Juan-Cerdán²,

Romeu-Garcia³

et al. 2016

Avicenna J Clin Microbiol Infect

Self Cite

View full text Add to dashboard Cite

Background: Serum vitamin D (VitD) status is associated with active tuberculosis (TB) and TB infection conversion (TBIC). Objectives: The objective of the present study was to quantify the risks of TB (latent, conversion, disease) in accordance with VitD status and other variables among the contacts of pulmonary TB patients. Methods: From 2009 to 2012, a cohort of the contacts of pulmonary TB patients was studied to rule out and prevent TB in Castellon (Spain). The exams performed included a tuberculin skin test (TST), a QuantiFERON Gold in-tube test® (QFTGIT), blood and radiographic tests, and an initial measurement of serum VitD status. Contacts who were initially without active TB were followed up through 2015. Multinomial logistic regression (MLR) analyses were carried out. Results: From a total of 572 contacts of pulmonary TB patients with VitD status measurement, 523 completed the follow-up (participation rate 91.4%). Among them, five groups could be established: 3 new cases of pulmonary TB (0.6%), 27 cases of TBIC (5.2%), 116 cases of latent TB infection (LTBI) (22.2%), 125 uninfected TB contacts with only one TST or QFTGIT measurement (23.9%), and 252 uninfected TB contacts with two TST or QFTGIT measurements (48.2%). The comparison of these five groups revealed several significant differences, including age, whether they were foreign-born, place of residence, social class, high exposure to an index case with sputum acid-fast bacilli (AFB), and VitD status. The MLR analysis for all groups, with the group of uninfected TB contacts with two TST or QFTGIT measurements as a reference, estimated that only two of these factors were significantly associated with TB in three or more groups; these factors were VitD status and high exposure and a sputum AFB-positive index case. VitD status was a protector against pulmonary TB with a relative risk (RR) of 0.86 (95% confidence interval [CI] 0.74 -0.99) and against TBIC (R = 0.95; 95% CI 0.91 -0.99), while it was not associated with LTBI (RR = 0.99; 95% CI 0.97-1.01). Only 34.0% of the contacts had sufficient VitD levels (≥ 30 ng/mL). Conclusions: Our results suggest that a sufficient VitD level could be a protective factor against TBIC and active TB.

show abstract

“…25hydroxyvitamin D levels lower than 80 nm in liter is generally believed to be deficient. Another new and different action which recently ascribed forvitamin D is its anti-proliferative and (14).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Zinc,Vitamin A &D Serum Levels Between Children With Respiratory Tract Infection And Healthy Individuals in two Iranian Referral Hospitals

Shokrollahi¹,

Movahedi²,

Nia³

et al. 2016

IOSR

View full text Add to dashboard Cite

show abstract

Latent tuberculosis infection, tuberculin skin test and vitamin D status in contacts of tuberculosis patients: a cross-sectional and case-control study

Cited by 47 publications

References 49 publications

The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases

Tuberculosis and Vitamin D Status Among the Contacts of Pulmonary Tuberculosis Patients

Comparison of Zinc,Vitamin A &D Serum Levels Between Children With Respiratory Tract Infection And Healthy Individuals in two Iranian Referral Hospitals

Contact Info

Product

Resources

About