Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study

Zhang, Lifan; Ma, Yanan; Jiang, Nan; Zou, Xiaoju; Zhang, Yueqiu; Zhang, Fengchun; Zeng, Xiaofeng; Zhao, Yan; Liu, Shengyun; Zuo, Xiaoxia; Wu, Huaxiang; Wu, Lijun; Li, Hongbin; Zhang, Zhiyi; Chen, Sheng; Zhu, Ping; Zhang, Miaojia; Qi, Wencheng; Liu, Yi; Liu, Huaxiang; Shi, Xiaochun; Liu, Xiaoqing

doi:10.1128/spectrum.00848-23

Cited by 1 publication

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“…To further rule out the impact of glucocorticoids, treatment exposures were analysed in other patients with RMD, with or without indeterminate QFT. First, as a previous report suggested that prednisone equivalent ≥60 mg/day contributes to false-negative readout of the T-SPOT TB assay, 10 our samples were below this threshold. Second, no significant difference in glucocorticoid exposure was observed between the patients with RMD with or without indeterminate QFT.…”

Section: Resultsmentioning

confidence: 61%

PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus

Wang,

Zhao,

Feng

et al. 2024

RMD Open

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BackgroundIndeterminate readout of the quantitative interferon-γ release test (QFT) forMycobacterium tuberculosisscreening is a specific laboratory finding for systemic lupus erythematosus (SLE), which may be due to T-cell exhaustion and abnormal programmed death receptor 1 (PD-1)/programmed death-ligand 1 (PD-L1) signalling.MethodsWe enrolled 104 patients with SLE and 225 with other rheumatic musculoskeletal diseases (RMDs) who presented to the outpatient clinic between 2020 and 2023. Twenty healthy donors served as the controls. The QFT was performed in all participants, and those with indeterminate results were compared among the groups. Immunophenotyping and functional assays were performed using blood mononuclear cells. Interferon (IFN)-γ was detected in vitro and ex vivo in patients with SLE with indeterminate or negative QFT results, before or after rituximab therapy.Results104 patients with SLE had a significantly higher rate of indeterminate QFT results was significantly higher (17.31%) than that of 225 patients with RMD (3.56%). Patients with SLE with indeterminate QFT had more active disease (SLEDAI-2K, mean 10.94 vs 4.02, p<0.0001), including a higher incidence of active nephritis (55.56% vs 29.07%). Indeterminate QFT in SLE is mainly caused by an insufficient IFN-γ response in CD8+T cells with exhausted immunophenotypes. The abnormal interaction between exhausted PD-1 high CD8+T cells and activated PD-L1 low memory B cells in SLE can be reversed with a PD-1 agonist or increased PD-L1 expression. Rituximab treatment indirectly reversed this IFN-γ response.ConclusionThe PD-1/PD-L1 signalling pathway, which governs the crosstalk between exhausted CD8+T cells and activated memory B cells, is a mechanistic explanation for insufficient interferon-γ response in patients with SLE.

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Section: Resultsmentioning

confidence: 61%

PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus

Wang,

Zhao,

Feng

et al. 2024

RMD Open

View full text Add to dashboard Cite

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Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study

Abstract: The burden of tuberculosis and systemic lupus erythematosus in China ranks among the top three in the world. Therefore, active screening for LTBI and preventive intervention in SLE patients are of great significance in China.

Cited by 1 publication

References 28 publications

PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus

PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus

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Latent Tuberculosis Infection and Associated Factors in Patients with Systemic Lupus Erythematosus: a Multicenter, Cross-Sectional Study

Abstract: The burden of tuberculosis and systemic lupus erythematosus in China ranks among the top three in the world. Therefore, active screening for LTBI and preventive intervention in SLE patients are of great significance in China.

Cited by 1 publication

References 28 publications

PD-1/PD-L1 governed cross-talk of exhausted CD8+T and memory B cells in systemic lupus erythematosus

PD-1/PD-L1 governed cross-talk of exhausted CD8+T and memory B cells in systemic lupus erythematosus

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PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus

PD-1/PD-L1 governed cross-talk of exhausted CD8⁺T and memory B cells in systemic lupus erythematosus