Latent inhibition is affected by phase of estrous cycle in female rats

Quinlan, Matthew G.; Duncan, Andrew; Loiselle, Catherine; Graffe, Nicole; Brake, Wayne G.

doi:10.1016/j.bandc.2010.08.003

Cited by 24 publications

(24 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the reported proestrus advantage in spatial tasks is inconsistent with other data in rats showing enhanced spatial reference memory in the Morris water maze during estrus relative to proestrus (Frye 1995;Warren and Juraska 1997;Sutcliffe et al 2007) or no effect of the cycle on spatial reference memory in the water maze or radial arm maze, spatial working memory in the radial arm maze, or spatial novelty in a T-maze (Berry et al 1997;Stackman et al 1997;Conrad et al 2004;Pompili et al 2010). In tasks modeling selective attention, rats trained during proestrus failed to show latent inhibition (Arad and Weiner 2008;Quinlan et al 2010). In object recognition tasks, rats and mice tested in proestrus have been reported to outperform those in diestrus and estrus, but other findings show intact object recognition memory in all phases of the cycle (Walf et al 2006(Walf et al , 2009Sutcliffe et al 2007;Paris and Frye 2008).…”

Section: Memory and The Estrous Cyclementioning

confidence: 62%

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

et al. 2015

View full text Add to dashboard Cite

Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17b-estradiol (E 2 ), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes the effects of E 2 on hippocampal spinogenesis, neurogenesis, physiology, and memory, with particular attention paid to the effects of E 2 in male rodents. The estrogen receptors, cell-signaling pathways, and epigenetic processes necessary for E 2 to enhance memory in female rodents are also discussed in detail. Finally, practical considerations for working with female rodents are described for those investigators thinking of adding females to their experimental designs.Hormones have long been known to play key roles in regulating learning and memory. Many hormones, including epinephrine, glucocorticoids, and insulin influence learning and memory via inverted U-shaped dose-response relationships in which memory is enhanced by moderate, but not low or high, hormone levels (Roozendaal 2000;Korol and Gold 2007;McNay and Recknagel 2011). Research from the past two decades has demonstrated that sex steroid hormones, particularly the potent estrogen 17b-estradiol (E 2 ), also regulate learning and memory in male and female rodents via an inverted U-shaped dose-response function that is influenced by estrogen receptor expression (Packard and Teather 1997a;Packard 1998;Foster 2012). Yet E 2 has not gained widespread acceptance as a hormonal modulator of memory in both females and males, perhaps because the majority of this research has been conducted in female rodents. Moreover, the common view of E 2 as a "female" hormone may contribute to the misperception that E 2 is not relevant for cognitive function in males. However, considerable evidence supports a vital role for E 2 in mediating neural function and behavior in male rodents. Therefore, it is important for investigators working with males to understand the ways in which E 2 and other sex steroid hormones (e.g., androgens, progestins, and other estrogens) may influence their brain regions and behaviors of interest.Another reason for investigators to be cognizant of sex steroid hormone-induced regulation of learning and memory is that males and females may respond differently to various treatments and environmental factors. A classic example is that of acute stress, which enhances classical conditioning and increases apical CA1 dendritic spine density in male rats, but impairs classical conditioning and decreases CA1 spine density in female rats (Wood and Shors 1998;Shors et al. 2001). Therefore, investigators hoping to comply with National Institutes of Health policies that encourage the inclusion of females in biomedical research must be aware that adding females to a study is not as simple as adding another group. In some ways, females are fundamentally different from males, the most obvious of which is the presence of reproductive...

show abstract

Section: Memory and The Estrous Cyclementioning

confidence: 62%

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The effects varied across the menstrual cycle: the association between estradiol and risk-taking was strongest during the mid-luteal phase where estradiol levels are relatively high. Interestingly, female rats during the proestrus phase of the menstrual cycle (in which E2 levels are also high), exhibit attenuated inhibition when compared to rats with low levels of E2 (Quinlan, Duncan, Loiselle, Graffe, & Brake, 2010). Moreover, this effect was not seen until puberty indicating it is dependent on the surge of hormones at puberty (Quinlan et al, 2010).…”

Section: Pubertal Hormones and (Neuro-) Behavioral Changes During Adomentioning

confidence: 99%

“…Interestingly, female rats during the proestrus phase of the menstrual cycle (in which E2 levels are also high), exhibit attenuated inhibition when compared to rats with low levels of E2 (Quinlan, Duncan, Loiselle, Graffe, & Brake, 2010). Moreover, this effect was not seen until puberty indicating it is dependent on the surge of hormones at puberty (Quinlan et al, 2010). Taken together, these data suggest that increased pubertal estradiol in females relates to less behavioral inhibition and increased risk-taking.…”

Section: Pubertal Hormones and (Neuro-) Behavioral Changes During Adomentioning

confidence: 99%

The Teenage Brain

Peper

Dahl

2013

Curr Dir Psychol Sci

211

View full text Add to dashboard Cite

In this paper we discuss the surging hormones of puberty and their influences on adolescent behavior. We describe why these issues represent an interesting and important area of investigation, emphasizing their contributions to a specific set of developmental processes at the heart of the transition from childhood to adolescence. We briefly review the neuroendocrine underpinnings of human puberty. Our review focuses on evidence for behavioral (and neurobehavioral) effects of gonadal hormones, and emphasizes the social and affective dimensions of these hormonal effects. More broadly, we consider how these hormonal events contribute to brain-behavior interactions that can bias early adolescent trajectories in both positive and negative directions, and in ways that may begin as small influences, but can spiral into large-scale effects over time. These influences also appear to play an important role in functional and structural brain development during adolescence. Finally we offer some thoughts on directions for future research in these areas.

show abstract

“…Instead, female rats exhibit greater LI than male rats (Bethus et al, 2005), whereas other researchers have not found marked sex differences in LI (Arad and Weiner, 2010). Regarding the oestrous cycle, female rats tested during prooestrous, when oestrogen levels are high, exhibit a marked attenuation of LI, in comparison with female rats in oestrous or dioestrous, when oestrogen levels are lower (Quinlan et al, 2010). In another study, female rats in oestrous during the pre-exposure phase and in dioestrous during the conditioning phase (oestrous-dioestrous group) displayed a normal LI as did male rats, whereas LI was absent in female rats at other stages of the oestrous cycle (Arad and Weiner, 2008).…”

mentioning

confidence: 96%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

353

187

View full text Add to dashboard Cite

Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

show abstract

Latent inhibition is affected by phase of estrous cycle in female rats

Cited by 24 publications

References 50 publications

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

The Teenage Brain

Sex differences in animal models of psychiatric disorders

Contact Info

Product

Resources

About