LATENT IMMUNOGLOBULIN G (Gm) ALLOTYPES: OCCURRENCE IN THE CEREBROSPINAL FLUID IN SOME NEUROPATHOLOGICAL STATES

Salier, J.P.; Jm, Goust; Link, H.; Pandey, Janardan P.; Daveau, Maryvonne; Fudenberg, H. Hugh

doi:10.1111/j.1744-313x.1983.tb00808.x

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Expression of latent immunoglobulin allotypes, i.e. allotypes inconsistent with serum phenotype, has been detected in individuals undergoing immunological disturbances, for example, in the cerebrospinal fluid of multiple sclerosis patients [15].…”

Section: Resultsmentioning

confidence: 99%

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin

Orchard

Young²,

Smith

et al. 1990

Vox Sanguinis

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A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.

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Section: Resultsmentioning

confidence: 99%

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin

Orchard

Young²,

Smith

et al. 1990

Vox Sanguinis

View full text Add to dashboard Cite

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“…We have presented evidence for latent allotypes in the CSF of patients with various neurological diseases, including multiple sclerosis, seizure disorder, and Parkinson's disease (Salier et al, 1983). We have presented evidence for latent allotypes in the CSF of patients with various neurological diseases, including multiple sclerosis, seizure disorder, and Parkinson's disease (Salier et al, 1983).…”

Section: Herpes Viruses Latent Gm Allotypes and Sczmentioning

confidence: 94%

Genetic etiology of schizophrenia

Pandey

2014

Psychiatric Genetics

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There is increasing evidence for the involvement of herpes simplex virus type 1 and human cytomegalovirus in the cognitive impairment of patients with schizophrenia (SCZ). Both herpes simplex virus type 1 and human cytomegalovirus have evolved strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. Immunoglobulin GM genes, genetic markers of IgG heavy chains located on chromosome 14, modify certain immunoevasion strategies of these viruses. Particular GM alleles are also associated with antibody responsiveness to gliadin or gluten sensitivity, an attribute reported to be prevalent in a significant proportion of SCZ patients. On the basis of these properties, I hypothesize that GM alleles are risk factors for SCZ and their evaluation could help genetically dissect the disease in different subsets and/or help unify some disparate areas of pathobiology (e.g. cognitive dysfunction and gluten sensitivity) affected in this disorder.

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“…al lotypes inconsistent with serum phenotype, has been de tected in individuals undergoing immunological disturb ances, for example, in the cerebrospinal fluid of multiple sclerosis patients [15].…”

Section: Resultsmentioning

confidence: 99%

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti-B of Donor Origin

Orchard¹,

Young²,

Smith³

et al. 1990

Vox Sanguinis

View full text Add to dashboard Cite

A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gml;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.

show abstract

LATENT IMMUNOGLOBULIN G (Gm) ALLOTYPES: OCCURRENCE IN THE CEREBROSPINAL FLUID IN SOME NEUROPATHOLOGICAL STATES

Cited by 9 publications

References 20 publications

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti‐B of Donor Origin

Genetic etiology of schizophrenia

Severe Intravascular Haemolysis in a Renal Transplant Recipient due to Anti-B of Donor Origin

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