Latent Class and Factor Analysis of DSM-IV ADHD: A Twin Study of Female Adolescents

Hudziak, James J.; Heath, Andrew C.; Madden, Pamela; Reich, Wendy; Bucholz, K.; Slutske, Wendy S.; Bierut, Laura J.; Neuman, Rosalin J.; Todd, Richard D.

doi:10.1097/00004583-199808000-00015

Cited by 230 publications

(204 citation statements)

References 34 publications

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“…The fact that it is possible to use LCA to carve out clinically significant phenomena in adolescents from the general population was demonstrated earlier by Hudziak et al [22]. They found evidence for the existence of three types of ADHD: an Inattention type, a Hyperactive/Impulsive type, and a combined type.…”

Section: Discussionmentioning

confidence: 81%

Classes of adolescents with disruptive behaviors in a general population sample

Sondeijker

Ferdinand

Oldehinkel

et al. 2005

Soc Psychiat Epidemiol

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Section: Discussionmentioning

confidence: 81%

Classes of adolescents with disruptive behaviors in a general population sample

Sondeijker

Ferdinand

Oldehinkel

et al. 2005

Soc Psychiat Epidemiol

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“…This statistical method creates phenotypically similar subgroups that may reflect aetiological homogeneity. 59 Eight latent classes found through twin analysis 55 have been broadly replicated in both extensions of the original and independent samples. 60,61 The latent classes so defined are familial, heritable and unlike the DSM-IV subtypes are more consistently reported to be independently transmitted.…”

Section: Reading Disabilitymentioning

confidence: 85%

“…One study 51 found no evidence of familial distinction between subtypes, a finding supported by analyses both of sibling pairs collected for a molecular genetic study 52 and of a twin sample. 53 In contrast, some twin studies based on general population samples [54][55][56] have found distinct genetic (and environmental) influences on the different subtype symptom scores.…”

Section: Reading Disabilitymentioning

confidence: 95%

Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies

et al. 2006

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It is well established that attention deficit hyperactivity disorder (ADHD) is a familial and highly heritable disorder. Consequently, much effort is being directed towards searching for specific susceptibility genes. There is a growing trend, across the field of complex disease genetics, towards undertaking secondary analyses based on refined phenotypic definitions and in testing whether specific susceptibility genes modify the phenotypic presentation of the disorder in question. It is crucial that good, empirically derived arguments are made before undertaking multiple analyses on different phenotype refinements. In this review article, we consider the evidence from genetic epidemiological studies as well as key clinical studies that provide guidance on examining the ADHD phenotype for the purpose of molecular genetic studies. Specifically, findings on categorical versus dimensional conceptualisations of ADHD, reporter effects, comorbidity, ADHD subtypes and persistence are reviewed. Current evidence suggests that for the purpose of identifying susceptibility genes for ADHD, parent and teachers should be used as informants and that focusing on the clinical diagnosis of ADHD is useful. There is also good empirical support in favour of examining antisocial behaviour in ADHD. Genetic studies of dimensional ADHD are useful for other complementary purposes.

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“…The results of the TDT test are also marginally significant (P = 0.053) when applied to the sample diagnosed by the earlier DSM-III-R criteria for probable or definite ADHD. Due to evidence suggesting possible genetic independence of ADHD subtypes, [4][5][6] we also conducted exploratory TDT analyses restricting the sample to those trios by ADHD subtype (Inattentive vs Combined/HyperactiveImpulsive). As seen in Table 2, the most robust evidence for linkage with the 240-bp allele was observed when the TDT analysis was restricted to those trios formed by probands meeting DSM-IV criteria for ADHD, Inattentive subtype (P = 0.005; 63 vs 35 transmissions).…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] Both the syndrome of ADHD 4 and the separate dimensions of inattention and hyperactivity appear to be under genetic regulation. 5,6 However, the mode of inheritance of ADHD appears to be complex and non-mendelian.…”

Section: Introductionmentioning

confidence: 99%