Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil

Assis, Tália Santana Machado de; Rabello, Ana; Werneck, Guilherme Loureiro

doi:10.1111/j.1365-3156.2012.03064.x

Cited by 27 publications

(32 citation statements)

References 29 publications

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“…Tália Machado de Assis [1], [2] , Paloma Nogueira Guimarães [1] , Edward Oliveira [1] , Vanessa Peruhype-Magalhães [1] , Luciana Inácia Gomes [1] and Ana Rabello [1] [1]. Laboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brasil.…”

Section: Acceptance and Potential Barriers To Effective Use Of Diagnounclassified

“…Laboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brasil. [2]. Centro Federal de Educação Tecnológica de Minas Gerais, Campus Contagem, Contagem, Minas Gerais, Brasil.…”

Section: Acceptance and Potential Barriers To Effective Use Of Diagnounclassified

“…The sensitivity and specificity of the Kala-Azar Detect TM in Brazil vary from 72.4% to 90% and from 90.6% to 100%, respectively (8) (9) (10) (11) . The IT LEISH® rapid test was also validated in Brazil, with sensitivity and specificity estimated at 92-93% and 92-98%, respectively (2) (9) .…”

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confidence: 99%

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Acceptance and potential barriers to effective use of diagnostic tests for visceral leishmaniasis in an urban area in Brazil

Assis

Guimarães

Oliveira

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Acceptance of the IT LEISH® and direct agglutination test-made in the Laboratório de Pesquisas Clínicas (DAT-LPC) by healthcare professionals and patients suspected of visceral leishmaniasis (VL) in Ribeirão das Neves was evaluated. Methods: Ninety-two patients and 47 professionals completed three questionnaires. Results: Eighty-eight (96%) patients considered fingertip blood collection a positive test feature, and 86% (37) and 91% of professionals considered the IT LEISH® easy to perform and interpret, respectively. All professionals classified the DAT-LPC as simple and easy. Conclusions: Patients and healthcare professionals in Ribeirão das Neves demonstrated a high degree of acceptance of the IT LEISH ® and DAT-LPC.

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Acceptance and potential barriers to effective use of diagnostic tests for visceral leishmaniasis in an urban area in Brazil

Assis

Guimarães

Oliveira

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…The IT LEISH test is also simple and easy to interpret but has two advantages over previously available rapid tests: (1) improved performance (sensitivity of 92%-93% and specificity of 92%-98%) 3,4 ; and (2) the test is standardized for use in serum or finger capillary blood. In this sense, the incorporation of the IT LEISH rapid test by the SUS improved VL diagnosis: the diagnosis became possible at bedside, and the results are available in 30 minutes.…”

Section: Introductionmentioning

confidence: 99%

“…Until 2014, the Brazilian Ministry of Health provided two serological tests to public health care services: indirect fluorescence antibody test (IFAT) for human leishmaniasis, developed by Immunobiological Tecnology Institute (Biomanguinhos), Oswaldo Cruz Foundation, Brazil, and the Kalazar Detect rapid test (InBios International, USA). The IFAT has a sensitivity and specificity of 88%-92% and 83%-88%, respectively 2,3 . The advantage of the IFAT is that it is produced in Brazil, however, it requires a laboratory infrastructure of medium complexity and specialized professionals.…”

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confidence: 99%

Budgetary impact of diagnostic tests for visceral leishmaniasis in Brazil

et al. 2017

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Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease

Boelaert

Verdonck

Menten

et al. 2014

Cochrane Database of Systematic Reviews

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Background The diagnosis of visceral leishmaniasis (VL) in patients with fever and a large spleen relies on showing Leishmania parasites in tissue samples and on serological tests. Parasitological techniques are invasive, require sophisticated laboratories, consume time, or lack accuracy. Recently, rapid diagnostic tests that are easy to perform have become available. Objectives To determine the diagnostic accuracy of rapid tests for diagnosing VL in patients with suspected disease presenting at health services in endemic areas. Search methods We searched MEDLINE, EMBASE, LILACS, CIDG SR, CENTRAL, SCI‐expanded, Medion, Arif, CCT, and the WHO trials register on 3 December 2013, without applying language or date limits. Selection criteria This review includes original, phase III, diagnostic accuracy studies of rapid tests in patients clinically suspected to have VL. As reference standards, we accepted: (1) direct smear or culture of spleen aspirate; (2) composite reference standard based on one or more of the following: parasitology, serology, or response to treatment; and (3) latent class analysis. Data collection and analysis Two review authors independently extracted data and assessed quality of included studies using the QUADAS‐2 tool. Discrepancies were resolved by a third author. We carried out a meta‐analysis to estimate sensitivity and specificity of rapid tests, using a bivariate normal model with a complementary log‐log link function. We analysed each index test separately. As possible sources of heterogeneity, we explored: geographical area, commercial brand of index test, type of reference standard, disease prevalence, study size, and risk of bias (QUADAS‐2). We also undertook a sensitivity analysis to assess the influence of imperfect reference standards. Main results Twenty‐four studies containing information about five index tests (rK39 immunochromatographic test (ICT), KAtex latex agglutination test in urine, FAST agglutination test, rK26 ICT, and rKE16 ICT) recruiting 4271 participants (2605 with VL) were included. We carried out a meta‐analysis for the rK39 ICT (including 18 studies; 3622 participants) and the latex agglutination test (six studies; 1374 participants). The results showed considerable heterogeneity. For the rK39 ICT, the overall sensitivity was 91.9% (95% confidence interval (95% CI) 84.8 to 96.5) and the specificity 92.4% (95% CI 85.6 to 96.8). The sensitivity was lower in East Africa (85.3%; 95% CI 74.5 to 93.2) than in the Indian subcontinent (97.0%; 95% CI 90.0 to 99.5). For the latex agglutination test, overall sensitivity was 63.6% (95% CI 40.9 to 85.6) and specificity 92.9% (95% CI 76.7 to 99.2). Authors' conclusions The rK39 ICT shows high sensitivity and specificity for the diagnosis of visceral leishmaniasis in patients with febrile splenome...

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Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil

Cited by 27 publications

References 29 publications

Acceptance and potential barriers to effective use of diagnostic tests for visceral leishmaniasis in an urban area in Brazil

Acceptance and potential barriers to effective use of diagnostic tests for visceral leishmaniasis in an urban area in Brazil

Budgetary impact of diagnostic tests for visceral leishmaniasis in Brazil

Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease

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