Latency of pancreatic enzyme response to intraduodenal stimulants

Singer, Monique; Solomon, Travis E.; Wood, John G.; Grossman, M. I.

doi:10.1152/ajpgi.1980.238.1.g23

Cited by 48 publications

(53 citation statements)

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“…It is assumed that these effects of distension are mediated by reflexes lying within the vagus nerves from knowledge of similar responses in anaesthetized animals (Abrahamsson, 1973;Andrews et al 1980 a) and the fact that the events described in this paper were not influenced by either a-or ,-adrenergic blocking agents, nor were they altered by guanethidine (T. Scratcherd, unpublished observation). Although the experimental protocol prevented the accurate assessment of response latency it is clear (for example, Figs 1 and 4) that responses occurred within the circulation time as measured by the injection of CCK into the canine portal vein (Singer, Soloman & Grossman, 1980); a hormonal mechanism therefore seems unlikely though hormones could modify the response.…”

Section: Discussionmentioning

confidence: 99%

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Grundy¹,

Hutson²,

Rudge³

et al. 1989

Exp Physiol

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SUMMARYReflex mechanisms regulating gastric motor function were studied in four conscious dogs, whose stomachs had been surgically divided into separate corporal and antral pouches. Interactions between the corpus and antrum were investigated in fasted animals by balloon distension of each region. During the quiescent phase (phase I) of the migrating motor complex (MMC), distending the corpus with volumes greater than 80 ml resulted in contractions of the corpus, which persisted for as long as the distending stimulus was applied. This corporal distension also initiated antral contractions which were greater if the antrum was moderately distended and also greater with a larger corporal distending volume up to 300 ml. Graded 5 ml inflation of the antrum during the quiescent phase of the MMC stimulated antral contractions. This antral response to antral distension was augmented when the corpus was inflated but was only statistically significant with antral volumes below 25 ml. Distension of the antrum with volumes > 12-5 ml caused inhibition of corporal contractions during both the active phase of a migrating complex or when stimulated by corporal inflation. The degree of inhibition was proportional to the distending stimulus and was present for the duration of the applied distension. For antral volumes of 50 ml the inhibition persisted for a variable time after the stimulus was withdrawn. The inhibition of corporal activity by antral distension was still effective after blocking acid secretion with cimetidine (100 mg), which would eliminate spillage of acid into the jejunum as a cause of the inhibition. It is concluded that pre-pyloric mechanisms co-ordinate corporal and antral motor activity and would operate during gastric emptying to provide a controlled delivery of chyme to the duodenum.

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Section: Discussionmentioning

confidence: 99%

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Grundy¹,

Hutson²,

Rudge³

et al. 1989

Exp Physiol

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“…Even in the presence ofa secretin background, the shortest latency ofthe response to intraduodenal tryptophan or oleate was greater than that following intraportal secretin or CCK octapeptide (which probably represents the minimal circulation time of either hormone). In an earlier study (Singer et al 1980b) the latency of the amylase response to intestinal instillation of oleate (20 s) or tryptophan (18 s) was found to be shorter than that to intraportal injection of CCK (34 s). Since truncal vagotomy and atropine increased the latency of the enzyme response to both intestinal stimulants but not to intraportal CCK it was concluded that a vago-vagal, cholinergic reflex mediates the early pancreatic enzyme responses to intestinal amino acids and fatty acids.…”

Section: Discussionmentioning

confidence: 85%

“…However, recent studies (Singer, Solomon & Grossman, 1980a;Singer, Solomon, Rammert, Caspary, Niebel, Goebell & Grossman, 1981;Solomon & Grossman, 1979) in dogs with a transplanted extrinsically denervated portion of pancreas indicate that an enteropancreatic, vago-vagal, cholinergic reflex is a major mediator of the pancreatic enzyme response to intestinal stimulants such as amino acids, fatty acids and HCl. In another recent study (Singer, Solomon, Wood & Grossman, 1980b), further evidence for the existence of such a reflex was provided by comparing the latency of amylase secretion by the intact innervated pancreas in response to intestinal stimulants with that in response to an intraportal injection of cholecystokinin (CCK). The latency of the amylase response to intraduodenal oleate and tryptophan was shorter than to intraportal CCK.…”

Section: Introductionmentioning

confidence: 99%

Latency of pancreatic fluid secretory response to intestinal stimulants in the dog.

Singer¹

1983

The Journal of Physiology

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SUMMARY1. The effect of atropine and truncal vagotomy on the latency of the secretary response of the exocrine pancreas to rapid intraduodenal injection of L-tryptophan, sodium oleate and HCl or to rapid intraportal injection of secretin or CCK octapeptide has been determined in conscious dogs with pancreatic fistulae. The intraduodenal stimulants were injected either alone or in the presence of an intravenous infusion of secretin, CCK octapeptide or a combination of both hormones.2. The mean latency of response to tryptophan alone (62 + 2 s), oleate alone (64 + 5 s) and HCl alone (91 + 3 s) was significantly longer (P < 0 05) than the latency to intraportal secretin (28 + 5 s) or CCK octapeptide (45 + 4 s). Infusion of secretin alone or with CCK octapeptide significantly shortened the latency of response to tryptophan (38+3 s) and oleate (41 + 5 s), but had no effect on the latency to intraduodenal HCO (96 + 4 s).3. Atropine and truncal vagotomy both increased the latency to intraduodenal tryptophan and oleate threefold but did not affect the latency to intraduodenal HCO or intraportal secretin or CCK octapeptide.4. These data support the hypothesis that the stimulus to pancreatic fluid secretion evoked by intraduodenal HCl is humoral rather than neural, while the responses to intraduodenal tryptophan and oleate are mediated, at least in part, via an enteropancreatic, vago-vagal, cholinergic reflex.

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“…In dogs, however, the latency of the response of pancreatic outflow due to increased secretin release caused by intraduodenal injection of 30-50 ml of 0.4°c HC1 is about 2 min (BAYLISS and STARLING, 1902). SINGER et al (1980) also reported in vagotomized dogs that the latencies of the increased amylase output due to CCK release by intraduodenal stimulants, sodium oleate and tryptophan, are about 3 min. 2) There are some differences in the time courses of the responses by the short reflex and endogenous secretin.…”

Section: Discussionmentioning

confidence: 95%

Effects of antral distension on pancreatic exocrine secretion dogs: Evidence for a short reflex.

Furukawa

Okada

1987

Jpn.J.Physiol

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In WHITE et al. (1960) found that distension of the gastric corpus in conscious dogs caused an increase in pancreatic secretion via the vago-vagal reflex. DEGAS and YAMAGISHI (1978) reported that distension of the pyloric antrum in conscious dogs caused an increase in pancreatic secretion mainly through the vago-vagal reflex and partly through a rise in the serum gastrin concentration. DEGAS and YAMAGISHI (1978) stated that acid distension of the pyloric antrum caused no rise in pancreatic secretion after truncal vagotomy.The gastropancreatic reflexes have not been reported in anesthetized dogs or decerebrated dogs. Most anesthetics markedly diminish both the nervous activity and pancreatic response to a given stimulus. However, BABKIN (1924) has stated that chloralose is a very suitable narcotic for the study of the pancreatic secretion.

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Latency of pancreatic enzyme response to intraduodenal stimulants

Cited by 48 publications

References 0 publications

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Latency of pancreatic fluid secretory response to intestinal stimulants in the dog.

Effects of antral distension on pancreatic exocrine secretion dogs: Evidence for a short reflex.

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