Latência da lidocaína a 1% para anestesia infiltrativa da pele

Almeida, Gustavo Paiva; Boos, Gustavo Luchi; Alencar, Tiago Gayer de; Filho, Getúlio Rodrigues de Oliveira

doi:10.1590/s0034-70942005000300005

Cited by 6 publications

(2 citation statements)

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“…The use of hyaluronidase, evaluated in the 15 studies sources [7,14,[15][16][17][18][19][20][21][22][23][24] regardless of the type and concentration of LA, hyaluronidase dose and regional blocking technique, was considered a protective factor against ocular akinesia failure in ophthalmic surgery (OR: 0.55; 95% CI: 0.32-0.93; p=0.027), as shown in Figure 2. (5 studies [14,19,20,22,23]; OR: 0.34; 95% CI: 0.09-1.34; p=0.12) or in PB (10 studies [7,[15][16][17][18][19][20][21][22][23][24][25][26][27][28]21,24]; OR: 0.65; 95% CI: 0.40-1.07; p=0.09). Still on the hyaluronidase dose, regardless of the type and concentration of LA and the regional blocking technique, the use of a dose greater than 100 IU / mL was considered a protective factor, as it prevented akinesia failure in ophthalmic anesthesia (7 studies [7,14,16,18,19,21,22]; OR: 0.43; 95% CI: 0.20-0.90; p=0.02) (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

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Addition of Hyaluronidase Reduces Failure of Regional Block in Ophthalmic Surgery: Meta-Analysis of Randomized Clinical Trials

Miranda

2020

BJSTR

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Objetive: To evaluate the efficacy of hyaluronidase in preventing total/partial failure of regional block in ophthalmic surgery.Method: Meta-analysis of randomized clinical trials, with patients undergoing ophthalmic procedures under peribulbar/subtenonian block, who received local anesthetic associated with hyaluronidase. The search for articles on PubMed used terms such as hyaluronidase, hyaluronoglucosaminidase and ophthalmology, or synonyms, using AND and OR interlocutors. Two independent researchers evaluated titles and abstracts. For those selected, there was complete reading of the text for inclusion in the sample. Manual search of references was also carried out. A random effects model (DerSimonian-Laird test) and Odds Ratios Calculation (OR) with 95% confidence intervals (95% CI) were used.Results: 242 studies identified, 12 were selected, including 1,328 patients (689 cases and 639 controls). The use of hyaluronidase was considered a protective factor against ocular akinesia failure in regional anesthesia (OR: 0.55; 95% CI: 0.32-0.93; p=0.027). The same was observed in the subgroups analysis with a hyaluronidase dose >100 IU / mL (OR: 0.43; 95% CI: 0.20-0.90; p=0.02) and association with bupivacaine (OR: 0.53; 95% CI: 0.33-0.84; p=0.01). Conclusion:This meta-analysis shows the efficacy of hyaluronidase associated with local anesthetics in preventing regional block failure in ophthalmic surgery.

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Section: Resultsmentioning

confidence: 99%

“…On the other hand, a disadvantage of bupivacaine relies in its more evident cardiotoxicity than lidocaine [27]. Lidocaine has a pKa closer to the physiological one, which implies shorter latency, faster onset of action, but also shorter duration, with the need to repeat supplementary doses, including intraoperatively [6,28].…”

Section: Discussionmentioning

confidence: 99%