Late ventricular dilatation in survivors of acute myocardial infarction

Gadsbøll, Niels; Høilund-Carlsen, Poul Fl.; Badsberg, Jens Henrik; Stage, P; Marving, J.; Lønborg-Jensen, H

doi:10.1016/0002-9149(89)90790-x

Cited by 49 publications

(13 citation statements)

References 20 publications

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“…As previous studies have shown that an increase in end-diastolic volume is predictive of a poor prognosis [4, 20, 33], this distinction might be important.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

Kaltoft

Bøttcher²,

Sand³

et al. 2003

Cardiology

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Following an acute myocardial infarction, the size of the infarct and the resulting left ventricular volume and function are important predictors of mortality. Identifying patients with impaired tissue level perfusion after percutaneous coronary intervention (PCI) for myocardial infarction therefore could have prognostic implications. To obtain combined measures of left ventricular perfusion, volumes and function we applied a gated myocardial perfusion imaging by ^99mTc-sestamibi single photon emission computerized tomography to 19 patients immediately after revascularization by PCI and repeated this after 3 months. The results of the acute myocardial perfusion imaging significantly correlated to final infarct size, left ventricular volumes and function 3 months later. It is concluded that the method holds the potential for risk stratifying patients immediately after revascularization for acute myocardial infarction.

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“…As previous studies have shown that an increase in end-diastolic volume is predictive of a poor prognosis [4, 20, 33], this distinction might be important.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

Kaltoft

Bøttcher²,

Sand³

et al. 2003

Cardiology

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“…Similar persistence of ventricular dilatation has been found in other studies.' 44 The optimal duration of captopril treatment remains to be defined but our results suggest that it should be continued for at least a year and possibly indefinitely. The lack of a change in ventricular volumes in the captopril group after the month of treatment withdrawal confirms that the reduction in ventricular dilatation is structural and not due simply to a rapidly reversible haemodynamic effect.…”

Section: Discussionmentioning

confidence: 86%

Early treatment with captopril after acute myocardial infarction.

Ray

Pye

Oldroyd

et al. 1993

Heart

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Objectives-To determine the effects of early treatment with captopril on haemodynamic function, neuroendocrine biochemistry, left ventricular structure, clinical outcome, and exercise capacity over one year from acute myocardial infarction.Design mlum' v 14*7 ml/ml (95% confidence interval (95% CI) of difference -14-6 to -3 9; p=0O0011); left ventricular end diastolic volume index 8-4 ml/ml v 19*0 mllm' (95% CI of difference, -17-0 to -4-2; p=00016). Withdrawal of captopril for one month did not affect ventricular volumes. There was no difference in exercise capacity.Conclusions-Captopril started between six and 24 hours after acute myocardial infarction is not associated with significant hypotension. It suppresses activation of the renin angiotensin system but has no effect on plasma concentrations of other neurohormones. Atrial natriuretic factor remains raised at two months after myocardial infarction. Captopril significantly decreases left ventricular dilatation. This effect is not lost after one month of treatment withdrawal and is thus due to an alteration of left ventricular structure and not to a short lived haemodynamic action of captopril. Long-term treatment with captopril does not result in improved aerobic exercise capacity after acute myocardial infarction. (Br Heart J 1993; 69:215-222)

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“…Ninety‐seven patients were eligible for the study []. Between hospital discharge and the 1‐year re‐investigation 18 patients died, seven had a recurrent AMI, two underwent coronary artery bypass surgery, one developed malignant disease and four patients did not want to participate in the 1‐year follow‐up.…”

Section: Methodsmentioning

confidence: 99%

“…The investigation was a follow‐up of a previous report concerning the spontaneous change in LV volume during the first year after AMI []. In that study, 57 hospital survivors of AMI underwent radionuclide ventriculography at discharge (1984–1985) and again 1 year later (1985–1986).…”

Section: Methodsmentioning

confidence: 99%

“…We have previously reported that spontaneous LV dilatation occurs in more than 50% of post‐AMI patients during the first year after hospital discharge []. The purpose of the present study was to examine the prognostic significance of this ‘first‐year’ increase in LV volume on long‐term survival in comparison with in‐hospital heart failure and established prognostic factors such as LV ejection fraction in a cohort of patients, who did not receive thrombolytic treatment or ACE‐inhibition post AMI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In‐hospital heart failure, first‐year ventricular dilatation and 10‐year survival after acute myocardial infarction

Gadsbøll

Torp‐Pedersen

Høilund‐Carlsen

2001

European J of Heart Fail

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Background: Little is known about the factors that determine long-term prognosis in patients who have survived the first Ž . Ž . year after acute myocardial infarction AMI . Aims: To study the influence of left and right ventricular LV and RV dilatation during the first year after AMI on subsequent 10-year survival in comparison with in-hospital heart failure and other established prognostic indices. Methods: Radionuclide ventriculography was performed before the era of thrombolysis and post-infarction ACE-inhibition in 57 patients with AMI at hospital discharge and again 1 year later, and compared with Ž . Ž . survival the ensuing 10 years. Results: After 1 year significant LV-dilatation ) 20% had occurred in 32 56% patients. One Ž . year after the re-investigation the mortality in these was 19% vs. 0% in patients without dilatation Ps 0.02 ; after 5 years the Ž . difference was 38 vs. 12% Ps 0.02 , whereafter it declined and became insignificant at 10 years. Neither RV-dilatation, nor LVEF determined at discharge or at the 1-year reinvestigation influenced long-term survival. In contrast, clinical heart failure recorded during the hospital stay had a sustained negative influence on long-term survival. Conclusion: Progressive LV dilatation after discharge and clinical heart failure during the hospital stay are both determinants of late survival after AMI, whereas LV ejection fraction at hospital discharge or 1 year later has little, if any, effect on survival beyond 1-year post-AMI.

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Late ventricular dilatation in survivors of acute myocardial infarction

Cited by 49 publications

References 20 publications

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

Early treatment with captopril after acute myocardial infarction.

In‐hospital heart failure, first‐year ventricular dilatation and 10‐year survival after acute myocardial infarction

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