Late Toxicity After 3-Dimensional External Beam Radiotherapy Among Children With Cancer: A Systematic Review

Abstract

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Adverse late health outcomes among children treated with 3D radiotherapy techniques: Study design of the Dutch pediatric 3D‐RT study

“…Because of this difference in dose distribution, insight in late adverse events following 3D‐RT is important. Our recent systematic literature review of observational studies on adverse health outcomes after 3D‐RT included 13 studies, most of which describe small patient cohorts (range of N : 5–246) with a median follow‐up of 8.8 years, 22 and showed that evidence on this topic is scarce. Most available studies to date reported on selected late health outcomes.…”

“…Although small studies on specific childhood cancer types have reported on side effects of 3D-RT, 21 large-scale observational studies including follow-up of patients beyond the 5-year survival mark are rare to date. 22 This study has expanded upon the resources of the Dutch Childhood Cancer Survivor Study (DCCSS) LATER Cohort of 5-year CCS 10,11,23 with the purpose of filling this evidence gap. In particular, the overall aim of the Dutch Pediatric 3D-RT study is to evaluate adverse late health outcomes among children treated with radiotherapy in the era of CT-based treatment planning, and to assess dose response relationships for selected health outcomes.…”

“…As such, the validity of extrapolating currently available evidence on late effects generated from data on 2D‐RT treatments to patients treated in the 3D‐era remains uncertain. Although small studies on specific childhood cancer types have reported on side effects of 3D‐RT, 21 large‐scale observational studies including follow‐up of patients beyond the 5‐year survival mark are rare to date 22 …”

“…Although small studies on specific childhood cancer types have reported on side effects of 3D‐RT, 21 large‐scale observational studies including follow‐up of patients beyond the 5‐year survival mark are rare to date. 22 …”

Radioterapia en pacientes pediátricos con leucemia linfocítica aguda: experiencia de 9 años

“…[19][20][21][22][23] La mayoría de los efectos secundarios son auto limitados (resuelven al disminuir el edema tisular), pero algunos efectos pueden ser tardíos o permanentes, como fibrosis, infertilidad o segundas malignidades. 19,20,24,25 Actualmente, aproximadamente el 98% de los niños con LLA alcanzan remisión con tratamiento y la sobrevida a 5 años ronda el 90%; 9,26 sin embargo, se ha descrito que hasta un 20% de los niños con LLA recaen. 11 En Costa Rica se han publicado estudios acerca del diagnóstico y tratamiento de la leucemia en población pediátrica, pero ninguno específico acerca del uso de radioterapia en el tratamiento de la LLA.…”