Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy

McFadden, Eugène; Stabile, Eugenio; Regar, Evelyn; Cheneau, Édouard; Ong, Andrew T.L.; Kinnaird, Timothy; Suddath, William O.; Weissman, Neil J.; Torguson, Rebecca; Kent, Kenneth M.; Pichard, A.D.; Satler, Lowell F.; Waksman, Ron; Serruys, Patrick W.

doi:10.1016/s0140-6736(04)17275-9

Cited by 1,266 publications

(318 citation statements)

References 6 publications

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“…Owing to limitations of polymeric carriers in drug-eluting stents, [11][12][13][14][15][16][17][18][19][20][21] the development of polymer-free drug delivery platforms has potential applications in stents. 10 Surface modification using SAMs is one of the promising techniques for delivering drugs from metal implants without polymeric carriers.…”

Section: Discussionmentioning

confidence: 99%

“…10 Most commercially available DESs use polymers to coat and release drugs. The limitations of using some polymeric carriers in DES are as follows: ͑a͒ polymer coatings undergo cracks, fissures, waviness, and other irregularities during stent expansion; 11 ͑b͒ inflammatory and hypersensitivity reactions to polymer coatings; [12][13][14][15][16][17][18] and ͑c͒ polymer coatings affect the normal vessel healing process 17,19,20 and this could cause late stent thrombosis. 18,19,21 Hence, there is a need for developing polymer-free drug delivery platform for coronary stents.…”

Section: Introductionmentioning

confidence: 99%

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Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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Polymer-based platforms in drug-eluting stents ͑DESs͒ can cause adverse reactions in patients. Hence, the development of a polymer-free drug delivery platform may reduce adverse reactions to DES. In this study, the use of a polymer-free platform, self-assembled monolayers ͑SAMs͒, is explored for delivering an antiproliferative drug ͓paclitaxel ͑PAT͔͒ from a stent material ͓cobalt-chromium ͑͑Cou Cr͒ alloy͔. Initially, carboxylic acid terminated phosphonic acid SAMs were coated on Cou Cr alloy. Two different doses ͑25 and 100 g / cm 2 ͒ of PAT were coated on SAM coated Cou Cr surfaces using a microdrop deposition method. Also, control experiments were carried out to coat PAT directly on Cou Cr surfaces with no SAM modification. The PAT coated specimens were characterized using the Fourier transform infrared spectroscopy ͑FTIR͒, scanning electron microscopy ͑SEM͒, and atomic force microscopy ͑AFM͒. FTIR spectra showed the successful deposition of PAT on SAM coated and control-Cou Cr surfaces. SEM images showed islands of high density PAT crystals on SAM coated surfaces, while low density PAT crystals were observed on control-Cou Cr alloy. AFM images showed molecular distribution of PAT on SAM coated as well as control-Cou Cr alloy surfaces. In vitro drug release studies showed that PAT was released from SAM coated Cou Cr surfaces in a biphasic manner ͑an initial burst release in first 7 days was followed by a slow release for up to 35 days͒, while the PAT was burst released from control-Cou Cr surfaces within 1-3 days. Thus, this study demonstrated the use of SAMs for delivering PAT from Cou Cr alloy surfaces for potential use in drug-eluting stents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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“…Both angioplasty and bare metal stents are associated with significant restenosis caused by neointimal hyperplasia that leads to a 14% incidence of reintervention (2). Recent reports have described late in-stent thrombosis in drug-eluting stents (3,4).…”

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confidence: 99%

Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow

Skelly

Chandiwal

Vosicky

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Injury caused by distention of the arterial wall by balloon angioplasty can result in apoptosis and vascular smooth muscle cell proliferation. Here, we report that a brief exposure of the arterial lumen to a genetically engineered, attenuated herpes simplex virus 1 blocks activation of caspase 3-dependent apoptosis and MAPKdependent cell proliferation induced by carotid artery balloon angioplasty and ligation to reduce blood flow. The procedure enables the restoration of the endothelial cell layer lining the lumen and prevents neointimal hyperplasia and restenosis. These findings have a broad application in prevention of balloon angioplasty-induced restenosis.neointimal hyperplasia ͉ restenosis ͉ vascular smooth muscle cells ͉ endothelial cells

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“…Drug eluting stent technologies were composed of sustained drug release systems encapsulating anti-proliferative drugs to inhibit the proliferation of smooth muscle cells and they have been discovered to reduce the rate of in-stent restenosis [15,16]. Nevertheless, the anti-proliferative role of the drugs may impede endothelialization and blood is uncovered to the stent struts and/or to the surface coating, obviously increasing the proclivity of thrombosis [17,18]. Delayed or impaired endothelialization also limits the long-term success against restenosis [17,19].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behaviour

Wang

et al. 2013

J. R. Soc. Interface.

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In this communication, we report a facile nanotopographical control over a stainless steel surface via an electrophoretic deposition of colloidal amphiphilic chitosan for preferential growth, proliferation or migration of vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs). Atomic force microscopy revealed that the colloidal surface exhibited a deposition time-dependent nanotopographical evolution, wherein two different nanotopographic textures indexed by 'kurtosis' (R kur ) value were easily designed, which were termed as 'sharp' (i.e. high peak-to-valley texture) surface and 'flat' (i.e. low peak-to-valley texture) surface. Cellular behaviour of VSMCs and HUVECs on both surfaces demonstrated topographically dependent morphogenesis, adherent responses and biochemical properties in comparison with bare stainless steel. The formation of a biofunctionalized surface upon a facile colloidal chitosan deposition envisions the potential application towards numerous biomedical devices, and this is especially promising for cardiovascular stents wherein a new surface with optimized texture can be designed and is expected to create an advantageous environment to stimulate HUVEC growth for improved healing performance.

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Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy

Cited by 1,266 publications

References 6 publications

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow

Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behaviour

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