Late thalamic atrophy in infarction of the middle cerebral artery territory in neonates

Giroud, Maurice; Fayolle, H.; Martin, Didier; Baudoin, N.; André, N; Gouyon, Jean Bernard; Nivelon, J L; Dumas, R

doi:10.1007/bf00570252

Cited by 15 publications

(6 citation statements)

References 13 publications

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“…A delayed presentation after the age of 2 months was observed in 40% to 65% of PAIS in previous studies. 2,10,11 The radiological presentation of PAIS in this cohort showed that most strokes (78%) were limited to the middle cerebral artery territory (with classical late thalamic atrophy 12 ). This finding is in keeping with other studies with corresponding rates of 74% or 89%.…”

Section: Discussionmentioning

confidence: 73%

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Darmency-Stamboul

Chantegret

Ferdynus

et al. 2012

Stroke

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Background and Purpose-Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. Methods-A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2007. Case patients were confirmed by review of brain imaging and medical records. Three control subjects per case were randomly selected from the study population by sex, term, place, and year of birth. Results-PAIS was confirmed in 32 patients and its incidence was one per 4400 live births.

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Section: Discussionmentioning

confidence: 73%

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Darmency-Stamboul

Chantegret

Ferdynus

et al. 2012

Stroke

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“…Children with neonatal middle cerebral artery (MCA) territory infarction may develop thalamic atrophy, but whether this has long-term implications for sensory perception is unclear. 34 In a study of 12 children and young adults with unilateral perinatal stroke, 4 had abnormal somatosensoryevoked potentials, but these children were unable to cooperate for further evaluation of sensory function. 35 In a study of 16 school-aged children with perinatal stroke, 6 (28%) had impaired visual function.…”

Section: Residual Effects Of Perinatal Strokementioning

confidence: 99%

Management of Stroke in Infants and Children

Roach¹,

Golomb²,

Adams³

et al. 2008

Stroke

872

377

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Purpose— The purpose of this statement is to review the literature on childhood stroke and to provide recommendations for optimal diagnosis and treatment. This statement is intended for physicians who are responsible for diagnosing and treating infants, children, and adolescents with cerebrovascular disease. Methods— The Writing Group members were appointed by the American Heart Association Stroke Council’s Scientific Statement Oversight Committee. The panel included members with several different areas of expertise. Each of the panel’s recommendations was weighted by applying the American Heart Association Stroke Council’s Levels of Evidence grading algorithm. After being reviewed by panel members, the manuscript was reviewed by 4 expert peer reviewers and by members of the Stroke Council Leadership Committee and was approved by the American Heart Association Science Advisory and Coordinating Committee. We anticipate that this statement will need to be updated in 4 years. Results— Evidence-based recommendations are provided for the prevention of ischemic stroke caused by sickle cell disease, moyamoya disease, cervicocephalic arterial dissection, and cardiogenic embolism. Recommendations on the evaluation and management of hemorrhagic stroke also are provided. Protocols for dosing of heparin and warfarin in children are suggested. Also included are recommendations on the evaluation and management of perinatal stroke and cerebral sinovenous thrombosis in children.

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“…31 One confounder is the existence of trans-synaptic antero- and retrograde neuronal atrophy. Cortical infarction over an extensive frontoparietal area perfused by the middle cerebral artery will cause delayed thalamic atrophy30 and macroscopic ipsilateral atrophy of the corticospinal tract at brainstem level above the decussation 2732 Precise delineation of the original focus of damage may not be straightforward when reviewed subsequently.…”

Section: Discussionmentioning

confidence: 99%

Perinatal cortical infarction within middle cerebral artery trunks

Govaert

Matthys

Zecic

et al. 2000

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aim-To define neonatal pial middle cerebral artery infarction. Methods-A retrospective study was made of neonates in whom focal arterial infarction had been detected ultrasonographically. A detailed study was made of cortical middle cerebral artery infarction subtypes. Results-Forty infarctions, with the exception of those in a posterior cerebral artery, were detected ultrasonographically over a period of 10 years. Most were confirmed by computed tomography or magnetic resonance imaging. Factor V Leiden heterozygosity was documented in three. The onset was probably antepartum in three, and associated with fetal distress before labour in one. There were 19 cases of cortical middle cerebral artery stroke. The truncal type (n=13) was more common than complete (n = 5) middle cerebral artery infarction. Of six infarcts in the anterior trunk, four were in term infants and five aVected the right hemisphere. Clinical seizures were part of the anterior truncal presentation in three. One of these infants, with involvement of the primary motor area, developed a severe motor hemisyndrome. The Bayley Mental Developmental Index was above 80 in all of three infants tested with anterior truncal infarction. Of seven patients with posterior truncal infarction, six were at or near term. Six of these lesions were left sided. Clinical seizures were observed in three. A mild motor hemisyndrome developed in at least three of these infants due to involvement of parieto-temporal nonprimary cortex. Conclusions-Inability to diVerentiate between truncal and complete middle cerebral artery stroke is one of the explanations for the reported diVerent outcomes. Severe motor hemisyndrome can be predicted from neonatal ultrasonography on the basis of primary motor cortex involvement. Clinical seizures were recognised in less than half of the patients with truncal infarction; left sided presentation was present in the posterior, but not the anterior truncal type of infarction. Asphyxia is a rare cause of focal arterial infarction.

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Late thalamic atrophy in infarction of the middle cerebral artery territory in neonates

Cited by 15 publications

References 13 publications

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Management of Stroke in Infants and Children

Perinatal cortical infarction within middle cerebral artery trunks

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