Late-stage reshaping of phage-displayed libraries to macrocyclic and bicyclic landscapes using multipurpose linchpin
Ratmir Derda,
Kejia Yan,
Mark Miskolzie
et al.
Abstract:Genetically-encoded libraries (GEL) are increasingly used for discovery of ligands for ‘undruggable’ targets that cannot be addressed with small molecules. However, there is currently no consensus whether ‘zero knowledge’ naïve libraries or libraries with pre-existing knowledge can offer a more effective path to discover molecular interactions. In this manuscript, we evaluated the feasibility of discovery of macrocyclic and bicyclic peptide from "non-zero knowledge" libraries. Foundational GEL platforms like p… Show more
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