Late stage modifications of phosphine oxide ligands by iron‐catalyzed hydrogen borrowing reactions

Blue‐Light Driven Iron‐Catalyzed Oxy‐phosphinylation of Activated Alkenes for β‐Ketophosphine Oxide Synthesis

“…[17,18] Interestingly, when using [CpFe(CO) 2 ] 2 (5 mol %) under visible light irradiation (LED bulb, hν > 500 nm), the hydrophosphination of styrene, acrylic derivatives and the double hydrophosphination of terminal arylalkynes with Ph 2 PH can be performed at 25-28 °C instead of 100 °C without light activation. [19] Following our continuous contribution in iron catalyzed transformations, [20] notably involving hydroelementations such as hydroboration or dehydrogenative borylation, [21] or via αalkylation reaction of methyldiarylphosphine oxides, [22] we report herein the iron-catalyzed oxo-phosphinylation of activated alkenes using secondary phosphine oxides leading to βketophosphine oxide derivatives under blue-light irradiation. (Scheme 1) To the best of our knowledge, there is no report dealing with such transformation using sole iron as a catalyst.…”

“…Following our continuous contribution in iron catalyzed transformations, [20] notably involving hydroelementations such as hydroboration or dehydrogenative borylation, [21] or via α‐alkylation reaction of methyldiarylphosphine oxides, [22] we report herein the iron‐catalyzed oxo‐phosphinylation of activated alkenes using secondary phosphine oxides leading to β‐ketophosphine oxide derivatives under blue‐light irradiation. (Scheme 1) To the best of our knowledge, there is no report dealing with such transformation using sole iron as a catalyst.…”