Late sexual transmission of Zika virus related to persistence in the semen

Turmel, Jean Marie; Abgueguen, P.; Hubert, B.; Vandamme, Yves Marie; Maquart, Marianne; Guillou‐Guillemette, Hélène Le; Leparc-Goffart, Isabelle

doi:10.1016/s0140-6736(16)30775-9

Cited by 192 publications

(152 citation statements)

References 3 publications

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“…Persistent replication in these tissues has been connected to diverse severe conditions, such as end-organ disease, platelet-related illness, and potentially blinding uveitis (8). Persistent ZIKV in the reproductive tissue is possibly responsible for a growing number of cases of sexually transmitted disease, with some studies predicting that this may become a major route of infection in the future (10, 86–92). Vaginal mucosa infection has also been related to fetal infection, further highlighting the impact of ZIKV persistence in the genital tract (9, 93).…”

Section: Discussionmentioning

confidence: 99%

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

Bassi

Sempere

Meyn

et al. 2018

Antimicrob Agents Chemother

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Flaviviruses constitute an increasing source of public health concern, with growing numbers of pathogens causing disease and geographic spread to temperate climates. Despite a large body of evidence supporting mutagenesis as a conceivable antiviral strategy, there are currently no data on the sensitivity to increased mutagenesis for Zika virus (ZIKV) and Usutu virus (USUV), two emerging flaviviral threats.

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Section: Discussionmentioning

confidence: 99%

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

Bassi

Sempere

Meyn

et al. 2018

Antimicrob Agents Chemother

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“…Sexual transmission of Zika virus has been associated with condomless anal sex and vaginal sex and possibly also with fellatio (17). Among reported cases of sexually transmitted Zika virus infection, the longest reported period between sexual contact that might have transmitted Zika virus and symptom onset was 32-41 days (based on an incubation period of 3-12 days) (18).…”

Section: Review Of Evidencementioning

confidence: 99%

Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure — United States, September 2016

Petersen

Meaney‐Delman

Neblett-Fanfair

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

111

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“…Partners of either sex, who had not traveled and lived in areas without arthropodborne transmission, developed Zika virus disease (ZVD) after oral, vaginal or anal sex with infected men [3][4][5] . Infection of the partner occurred for up to 41 days after the index infection 6 .…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Zika virus persistence in semen

Huits

Smet

Ariën

et al. 2016

Bull. World Health Organ.

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ObjectiveInterim guidelines to prevent sexual transmission of Zika virus (ZIKV) do not recommend diagnostic testing, because the knowledge of viral kinetics in semen after acute infection is limited. We studied the presence and duration of ZIKV in semen after onset of symptoms. MethodsA prospective observational cohort study (NCT 02733796) is ongoing to determine the presence, persistence and kinetics of ZIKV in semen of men with confirmed ZIKV infection after returning from areas with vector-borne transmission. ZIKV RT-PCR is performed in weekly semen samples until ZIKV is no longer detectable. The main endpoint is the proportion of ZIKV positive semen samples over time after acute ZIKV infection. We report preliminary findings after enrolment of the first 4 patients. FindingsSemen of two out of four immunocompetent men with symptomatic ZIKV infection tested positive for ZIKV-RNA by RT-PCR. ZIKV levels in semen declined to undetectable after 68 and 56 days respectively, suggesting elimination of the virus. ConclusionOur findings indicate that presence and persistence of ZIKV in semen after acute infection appear common. Algorithms can be developed that incorporate ZIKV-specific molecular and antibody detection assays and subsequent testing for ZIKV in semen of selected men. We suggest that future guidelines to prevent sexual transmission of ZIKV, adopt diagnostic testing of both symptomatic and asymptomatic individuals returning from endemic areas.

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Late sexual transmission of Zika virus related to persistence in the semen

Abstract: during sex for 1 month after their return-should be extended, especially in the case of sexual intercourse involving women of reproductive age. 4,5 We declare no competing interests.

Cited by 192 publications

References 3 publications

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure — United States, September 2016

Kinetics of Zika virus persistence in semen

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