Late sequelae of symptomatic epidural compression in children with localized neuroblastoma

Angelini, Paola; Plantaz, Dominique; Bernardi, Bruno; Passagia, J.-G.; Pastore, Guido

doi:10.1002/pbc.23037

Cited by 32 publications

(82 citation statements)

References 23 publications

(32 reference statements)

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“…The association between the primary tumor location and the prevalence of spinal deformity is disputed. Two studies found more spinal deformity with thoracic located tumors, while two other studies did not found such an association …”

Section: Resultsmentioning

confidence: 92%

“…also found an advantageous outcome for the group treated with chemotherapy in comparison with neurosurgery; however, this difference did not reach statistical significance . The symptomatology at diagnosis (motor deficit and/or sphincter dysfunction) has strong predictive value for sphincter problems experienced at the end of follow‐up …”

Section: Resultsmentioning

confidence: 96%

“…None of the studies reported that the outcome was assessed by an investigator who was blinded for the treatment status of the patients. Eight studies (28.6%) assessed the influence of prognostic/risk factors on survival, neurological outcome, and/or long‐term health problems . Only two studies (7.1%) adjusted for possible confounders in a multivariate analysis …”

Section: Resultsmentioning

confidence: 99%

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Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Kraal

Blom

Noesel

et al. 2017

Pediatric Blood & Cancer

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We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

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Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Kraal

Blom

Noesel

et al. 2017

Pediatric Blood & Cancer

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“…Follow-up time (52, 99) and concomitant radiotherapy (107, 108) influence the effects of surgery on spinal malalignment. In a study of neuroblastoma survivors, Paulino et al .…”

Section: Resultsmentioning

confidence: 99%

“…(52) observed that those treated with laminectomy developed scoliosis after a median of 23 months, and those treated with radiotherapy developed scoliosis after a median of 68.5 months. Among 98 neuroblastoma survivors with symptomatic epidural compression, the prevalence of spinal deformity among those who had chemotherapy, radiotherapy and surgery was 62.5% compared to those who had chemotherapy and surgery (30%) or surgery alone (50%) (108). …”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

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Survivors of childhood cancer are at risk for treatment-related musculoskeletal late effects. Early detection and orthopedic intervention can help ameliorate musculoskeletal late effects and prevent subsequent complications. This systematic review summarizes the literature describing associations between cancer, its treatment, and musculoskeletal late effects. We searched PubMed and Web of Science for English language articles published between January 1970 and December 2012. The search was limited to investigations with at least 15 participants and conducted at least 2 years after completion of therapy for childhood, adolescent, or young adult cancer. Some late skeletal effects, including low bone mineral density, osteonecrosis, slipped capital femoral epiphyses, oncogenic rickets, and hormone-related growth disturbances have been previously reviewed and were excluded, as were outcomes following amputation and limb-salvage procedures. Of 2347 references identified, 30 met inclusion criteria and were retained. An additional 54 studies that met inclusion criteria were found in reference lists of retained studies. Of 84 studies, 60 focused on associations between radiotherapy, six between chemotherapy, and 18 between surgery and musculoskeletal late effects. We found that younger age, higher radiation dosage, and asymmetric or partial bone radiation volume influences the effects of radiation on the musculoskeletal system. Methotrexate and vincristine are associated with long-term muscular strength and flexibility deficits. Laminectomy and chest wall resection are associated with spinal malalignment, and enucleation is associated with orbital deformities among survivors. Radiotherapy, chemotherapy, and surgery are associated with musculoskeletal late effects independently and additively. Associations are additionally influenced by host and treatment characteristics.

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Neuroblastoma with symptomatic epidural compression in the infant: The AIEOP experience

Bernardi

Quaglietta

Haupt

et al. 2014

Pediatric Blood & Cancer

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Late sequelae of symptomatic epidural compression in children with localized neuroblastoma

Abstract: Fifty-eight percent of the children with localized neuroblastoma and symptomatic EC registered in this study developed late sequelae. The severity of motor deficit at diagnosis was the main risk factor.

Cited by 32 publications

References 23 publications

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Neuroblastoma with symptomatic epidural compression in the infant: The AIEOP experience

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