Late Recurrences Following Radical Cystectomy Have Distinct Prognostic and Management Considerations

PET Imaging in Bladder Cancer: An Update and Future Direction

“…In summary, [ 18 F]FDG-PET/CT seems to slightly improve sensitivity for the detection of pelvic lymph node involvement compared to CT, but in a non-selected population this improvement may be considered too low since both modalities have good specificity but relatively poor sensitivity. [ 18 F]FDG-PET/CT may be particularly useful in selected patients with enlarged lymph nodes seen on morphological imaging, whether to rule out lymph node involvement and enable curative treatment [23], or to confirm lymph node neoplastic spread and reveal potential additional metastases (Figures 2 and 3). studies have evaluated the role of [ 18 F]FDG-PET/CT for the detection of distant metastases, with sensitivities ranging from 54 to 87% and specificities ranging from 90% to 97% in a per-patient analysis [25][26][27][28].…”

Nivolumab (Opdivo)

“…• CADTH identified published literature that raises concerns as to whether adjuvant treatment might lead to overtreatment of patients, and whether it will actually lead to improvements in OS when used in all patients when compared with use after the first relapse (i.e., only received by the group of patients that ultimately need treatment). [21][22][23] Overall Conclusions…”

This Month in Adult Urology

“…Dason et al (page 460) from New York, New York evaluated the characteristics and prognosis of patients with late recurrence. 11 A total of 617 patients from a cohort of 2,315 had recurrence and 58 of these had late recurrence (more than 3 years after surgery). Overall 66%, 50% and 33% died within 1 year when recurrence was within 6 months, 2 years or 5 years after surgery, respectively.…”