Late rectal bleeding following combined x-ray and proton high dose irradiation for patients with stages T3–T4 prostate carcinoma

Benk, Veronique; Adams, Judy; Shipley, William U.; Urie, Marcia; McManus, P.L.; Efird, Jimmy T.; Willett, Christopher G.; Goitein, Michael

doi:10.1016/0360-3016(93)90978-5

Cited by 143 publications

(23 citation statements)

References 20 publications

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“…The clinical relevance of dose reductions below the 70% isodose level is not clearly understood. Most investigations correlated acute and/ or late toxicity with rectal DVH patterns especially in the high dose area [5,13,16,25,26,35]. These results support a relationship between the dose delivered to the rectal wall and the development of complications.…”

Section: A) Ptv I Photons I Photons Ii Imrt Protonssupporting

confidence: 64%

Comparative Treatment Planning on Localized Prostate Carcinoma

et al. 2005

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Section: A) Ptv I Photons I Photons Ii Imrt Protonssupporting

confidence: 64%

Comparative Treatment Planning on Localized Prostate Carcinoma

et al. 2005

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“…Most studies using a combination of HDR brachytherapy and external beam radiation found the incidence of grade 2 or greater proctitis to be less frequent (1.9-11.4%) (15)(16)(17)(18)(19)(20). Treatment plans exposing more than 40% of the anterior rectum to more than 75 Gy with conventional fractionation have been associated with an increase in the incidence of rectal bleeding (21). This accounts in part for the higher incidence of rectal bleeding in this study.…”

Section: Discussionmentioning

confidence: 46%

“…Rectal bleeding subsided spontaneously in the others. Proctologic complications following conventional external radiation for prostate cancer have been reported to range from 6.6 to 14% (21). Most studies using a combination of HDR brachytherapy and external beam radiation found the incidence of grade 2 or greater proctitis to be less frequent (1.9-11.4%) (15)(16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Health-related Quality of Life During and After High Dose Rate Brachytherapy Followed by External Beam Radiotherapy for Prostate Cancer

Egawa

Shimura²,

Irie³

et al. 2001

Japanese Journal of Clinical Oncology

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Background:The optimal protocol for combining high dose rate brachytherapy and external beam irradiation as treatment for localized prostate cancer is unknown. Toxicity rates and clinical and biochemical outcomes should be evaluated to validate the current treatment protocol. Methods: Fifty-eight patients were treated for prostate cancer with high dose rate brachytherapy followed by 30 Gy of external beam radiation therapy. Toxicity during treatment and for 12-18 months thereafter, and treatment-related morbidity, were evaluated. Physician-assessed treatment-related toxicity was graded at the time of occurrence using the Radiation Therapy Oncology Group morbidity criteria. Four separate self-administered questionnaires were used to collect longitudinally demographic data and general and prostate disease-related measures of quality of life. Results: Various degrees of rectal bleeding due to radiation proctitis were experienced by 13 patients (22%) at a median time of 11 months. Two of these patients needed hospitalization to undergo laser coagulation of the rectal mucosa. Study patients had statistically significant decreases in five SF-36 domains during the first month of treatment. All measures recovered by 12 months. Sexual function was not affected by irradiation. Lower urinary tract symptoms assessed by IPSS/QOL scores worsened significantly during the first month of treatment but later recovered to baseline levels. Physician-assessed RTOG scores failed to detect these changes. Conclusions: Morbidity associated with combined radiation therapy was greatest during the first month of treatment and affected quality of life significantly. Most measures recovered to baseline levels by 12 months following radiation therapy. Although the current protocol appears acceptable, measures should be taken to decrease treatment-related morbidity further. Key words: prostate cancer -high dose rate brachytherapy -external beam radiotherapy -quality of life

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“…Survival rates in both groups were similar. As a positive effect of the study it contributed to awareness of partial rectal wall tolerance (Hartford et al 1996;Benk et al 1993).…”

Section: Stage I: Safety Feasibilitymentioning

confidence: 95%

Proton Therapy for Prostate Cancer: Technological and Clinical Aspects

Schneider

2014

Radiotherapy in Prostate Cancer

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Late rectal bleeding following combined x-ray and proton high dose irradiation for patients with stages T3–T4 prostate carcinoma

Cited by 143 publications

References 20 publications

Comparative Treatment Planning on Localized Prostate Carcinoma

Comparative Treatment Planning on Localized Prostate Carcinoma

Toxicity and Health-related Quality of Life During and After High Dose Rate Brachytherapy Followed by External Beam Radiotherapy for Prostate Cancer

Proton Therapy for Prostate Cancer: Technological and Clinical Aspects

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