Late presenters among newly diagnosed HIV-infected in Poland in 2006-2008

Pyziak-Kowalska, Karolina; Dusza, Marta; Mularska, E.; Kalinowska-Nowak, Anna; Jabłonowska, Elżbieta; Barałkiewicz, Grażyna; Bander, Dorota; Podlasin, Regina; Kubicka, Joanna

doi:10.5114/hivar.2017.72025

Cited by 2 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first Polish data collected from several centres for 1100 newly diagnosed HIV‐infected Polish patients in the 2006–2008 period showed that almost 50% were late presenters, with a median CD4 count at diagnosis of 355 cells/μL. Older age and male PWID were risk factors for delayed care entry . However, data from a smaller single‐centre study in Poland showed a very high (63%) incidence of late presentation for HIV infection.…”

Section: Discussionmentioning

confidence: 99%

“…This has been associated with improved prognosis and a decrease in mortality among HIV‐infected patients. Delayed HIV diagnosis and late care entry, linked to late presentation either with diagnosed AIDS or with low CD4 counts, remain major challenges for the control of the HIV/AIDS epidemic, with single‐centre data indicating that 50 to 63% of individuals were linked to care with either AIDS or a CD4 count < 350 cells/μL, despite expansion of test and treat efforts in Poland .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

et al. 2019

View full text Add to dashboard Cite

Introduction Delay in HIV diagnosis and consequently late care entry with low CD4 counts remain a major challenge for the control of the HIV/AIDS epidemic. The aim of this study was to analyse the evolution of characteristics of the HIV epidemic in Poland. Methods Cross‐sectional data were collected for 3972 HIV‐infected patients followed up in 14 of 17 Polish HIV treatment centres in the years 2000–2015. Clinical data were analysed and factors associated with late presentation (baseline CD4 count < 350 cells/μL or history of AIDS‐defining illness) and advanced HIV disease (baseline CD4 count < 200 cells/μL or history of AIDS) were identified. Results The majority (57.6%) of patients entered care late, while 35.6% presented with advanced HIV disease. The odds of being linked to care late or with advanced HIV disease increased consistently across age categories, increasing from 2.55 [95% confidence interval (CI) 1.46–4.47] for late presentation and 3.13 (95% CI 1.49–6.58) for advanced disease for the 21–30‐year‐old category to 5.2 (95% CI 1.94–14.04) and 8.15 (95% CI 2.88–23.01), respectively, for individuals > 60 years of age. Increased risks of late entry and advanced HIV disease were also observed for injecting drug users [adjusted odds ratio (aOR) 1.74 (95% CI 1.16–2.60) and 1.55 (95% CI 1.05–2.30), respectively], with lower aOR associated with the men who have sex with men transmission route [aOR 0.3 (95% CI 0.31–0.59) and 0.39 (95% CI 0.29–0.53), respectively]. The frequencies of cases in which patients were linked to care late and with advanced HIV disease decreased over time from 67.6% (2000) to 53.5% (2015) (P < 0.0001) and from 43.5% (2000) to 28.4% (2015) (P = 0.001), respectively. Conclusions Despite improvements over time, most patients diagnosed with HIV infection entered care late, with a third presenting with advanced HIV disease. Late care entry remains common among people who inject drugs and heterosexual groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In a number of countries, including Poland, as many as 45–60% of patients are diagnosed with HIV/AIDS very late and at the stage of full-blown AIDS, usually with severe immunodeficiency and a CD4 T-lymphocyte count below 350 cells/mm 3 (late presenters). This requires quick and complex diagnostics and the fastest possible introduction of cART therapy [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Neurological Disorders of Patients Living with HIV Hospitalized in Infectious Departments of the Specialist Hospital in Lower Silesia in Poland

Janocha-Litwin

Simon

2022

Healthcare

View full text Add to dashboard Cite

Background and Objectives: Central nervous system (CNS) disorders are estimated to occur in approximately 10–20% of people living with HIV (PLWH). They are more commonly observed in newly diagnosed patients and in previously untreated patients or those refusing to undergo antiretroviral treatment. CNS diseases can also be the first manifestation of HIV/AIDS infection. The most common HIV-related central nervous system diseases (CNS-D) are CNS toxoplasmosis, CNS cryptococcosis, progressive multifocal leukoencephalopathy (PML), and HIV-associated encephalopathy treated as a neurocognitive disorder. Materials and Methods: A retrospective analysis of available medical records was performed on 476 patients hospitalised over a period from 2016 to 2021 and diagnosed with HIV/AIDS infection at the department of infectious diseases at the Provincial Specialist Hospital in Wroclaw. An additional criterion for selecting patients for the analysis was the performance of head imaging using computed tomography or magnetic resonance imaging on prospective patients. Results: Neurotoxoplasmosis, neurocryptococcosis, progressive multifocal leukoencephalopathy (PML), and neurosyphilis were the most common CNS diseases among the analysed group of patients. Based on radiological descriptions, other abnormalities, such as vascular changes or cortical and subcortical atrophy of multifactorial origin, not exclusively related to HIV infection, were also frequently observed. The most common neurological symptoms reported in the study group were headaches, limb paresis, and gait and balance disturbance. Conclusions: The clinical picture and epidemiology of neurological manifestations in the group of HIV-infected patients under assessment were similar to the results of other authors. Given the current epidemiological situation, diagnosis for HIV infection should be considered in patients admitted to neurological departments.

show abstract

Late presenters among newly diagnosed HIV-infected in Poland in 2006-2008

Abstract: Introduction: Assessment of incidence and factors associated with late vs. early human immunodeficiency virus (HIV) diagnosis among newly diagnosed patients referred to HIV treatment centres in Poland in the years 2006-2008.

Cited by 2 publications

References 23 publications

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

Long‐term trends in HIV care entry: over 15 years of clinical experience from Poland

Neurological Disorders of Patients Living with HIV Hospitalized in Infectious Departments of the Specialist Hospital in Lower Silesia in Poland

Contact Info

Product

Resources

About