Late positive potential as a candidate biomarker of motivational relevance in substance use: Evidence from a meta-analysis

Webber, Heather E.; Dios, Constanza de; Kessler, Danielle A.; Schmitz, Joy M.; Lane, Scott D.; Suchting, Robert

doi:10.1016/j.neubiorev.2022.104835

Cited by 15 publications

(13 citation statements)

References 92 publications

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“…The LPP is a stimulus-evoked slow wave that is maximal at central–parietal/frontal–central sites and is reliably enhanced to motivationally significant relative to neutral stimuli (Hajcak & Foti, 2020). Consistent with the drug cue LPP’s conceptualization as a neural index of incentive salience, multiple studies have found greater LPP enhancement to drug cue versus neutral images in those with SUDs compared to controls (see Webber, de Dios, Kessler, Schmitz, et al, 2022, for meta-analysis). Further, other measures of drug use motivation, including craving (Franken et al, 2003, 2008), cue-elicited emotional arousal (Franken et al, 2003), drug cue attention bias (Webber, de Dios, Wardle, Suchting, et al, 2022), current versus ex-user status (Littel & Franken, 2007), substance use frequency/quantity (Cheng et al, 2016; Dunning et al, 2011), and simulated drug choice behavior (Moeller et al, 2012), positively correlate with drug-cue-elicited LPP amplitude, providing additional evidence of validity.…”

Section: Participantsmentioning

confidence: 84%

Physiological stress modulation of neural drug cue reactivity in cannabis use disorder.

Macatee¹,

Preston²,

Afshar³

et al. 2023

Psychology of Addictive Behaviors

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Objective: Rates of daily cannabis use and cannabis use disorder (CUD) are increasing in the United States. Prominent addiction theories suggest that stress potentiation of drug cue incentive salience is a central feature of disordered versus recreational drug use, which has been corroborated using a neurophysiological index of drug cue incentive salience (i.e., the late positive potential [LPP]) in adults who regularly use cannabis. However, the mechanism through which acute stress potentiates the cannabis LPP in CUD is unclear. Method: To address this gap, cannabis LPPs were measured before and after a stress induction in 95 adults who regularly use cannabis. Physiological (hypothalamic-pituitary-adrenal [HPA] axis, heart rate, skin conductance) and subjective stress reactivity were also measured. Results: Based on prior work, we hypothesized that cortisol stress reactivity would predict poststress cannabis LPP enhancement in more severe CUD. The hypothesis was supported and specific to HPA-axis versus autonomic or subjective stress reactivity. Conclusions: Acute stress potentiation of the cannabis LPP, likely via HPA-axis activation, may be a biomarker of heavy/disordered cannabis use in adults who regularly use cannabis. Public Health Significance StatementHeightened reward value of drug-related cues is a key feature of substance use disorders, including cannabis use disorder. This study suggests that the activation of the hypothalamic-pituitary-adrenal axis may underlie stress potentiation of neurophysiological cannabis cue reactivity in cannabis use disorder, representing a novel stress-related mechanism sensitive to disorder severity and independent of subjective craving.

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Section: Participantsmentioning

confidence: 84%

Physiological stress modulation of neural drug cue reactivity in cannabis use disorder.

Macatee¹,

Preston²,

Afshar³

et al. 2023

Psychology of Addictive Behaviors

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“…Macatee and colleagues (2019) measured the late positive potential (LPP) to cannabis cues, an event-related potential recorded using electroencephalography (EEG), before and after an acute stress induction in regular cannabis users varying in CUD severity. Consistent with the drug cue LPP's conceptualization as a neural index of incentive salience, multiple studies have found greater LPP enhancement to drug cue vs. neutral images in those with substance use disorders compared to controls (see Webber et al, 2022a for meta-analysis). Further, other measures of drug use motivation, including craving (Franken et al, 2003;Franken et al, 2008), cue-elicited emotional arousal (Franken et al, 2003), drug cue attention bias (Webber et al, 2022b), current vs. ex-user status (Littel & Franken, 2007), substance use frequency/quantity (Cheng et al, 2016;Dunning et al, 2011), and simulated drug choice behavior (Moeller et al, 2012), positively correlate with drug-cue elicited LPP amplitude, providing additional evidence of validity.…”

Section: Introductionmentioning

confidence: 83%

Physiological stress reactivity’s role in post-stress modulation of the drug cue-elicited late positive potential in Cannabis Use Disorder

Macatee¹,

Preston²,

Afshar³

et al. 2022

Preprint

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Rates of daily cannabis use and Cannabis Use Disorder (CUD) are increasing in the United States. To inform risk prediction and treatment development efforts, it is imperative to identify reliable neurobiological markers of CUD severity in at-risk populations such as regular cannabis users. Prominent addiction theories suggest that stress potentiation of drug cue incentive salience is a central feature of disordered vs. recreational drug use, which has been corroborated using a neurophysiological index of drug cue incentive salience (i.e., the late positive potential [LPP]) in cannabis users. However, the mechanism through which acute stress potentiates the cannabis LPP in CUD is unclear. To address this gap, cannabis LPPs were measured in 102 cannabis users before and after a stress induction. Physiological [hypothalamic- pituitary-adrenal (HPA) axis, heart rate, skin conductance] and subjective stress reactivity were also measured. An additional cannabis user control group (n=52) completed a single lab visit with a non-stressful task to validate the stress induction. Based on prior work, we hypothesized that cortisol stress reactivity would predict post-stress cannabis LPP enhancement in more severe CUD. The hypothesis was supported, specific to HPA-axis vs. autonomic or subjective stress reactivity, and independent of subjective craving. Acute stress potentiation of the cannabis LPP, likely via HPA-axis activation, may be a biomarker of heavy/disordered cannabis use in regular users.

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“…Reference lists of selected reviews were consulted to ensure other relevant work was not overlooked. Other ERP terms above, including “late positive potential” and “slow positive wave,” were used for a separate project and are not presented here (Webber et al., 2022).…”

Section: Methodsmentioning

confidence: 99%

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

Webber,

de Dios,

Kessler

et al. 2024

Psychophysiology

Self Cite

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Substance use disorders are characterized by marked changes in reward and error processing. The primary objective of this meta‐analysis was to estimate effect sizes for the reward positivity (RewP) and error‐related negativity (ERN), two event‐related potential indicators of outcome monitoring, in substance users compared to controls. The secondary objective was to test for moderation by demographic, substance type, and EEG experiment parameters. Final PubMed searches were performed in August 2023. Inclusion criteria were substance use disorder/dependence or validated self‐report of substance misuse, RewP/ERN means available, healthy control comparison group, non‐acute drug study, peer‐reviewed journal, English language, and human participants. Selection bias was tested through modified Egger's regression and exploratory 3‐parameter selection model tests. The RewP results (19 studies, 1641 participants) did not support an overall effect (Hedges' g = 0.07, 95% CI [−0.44, 0.58], p = .777) and nor effect of any moderators. The ERN results (20 studies, 1022 participants) indicated no significant overall effect (g = 0.41, 95%CI [−0.05, 0.88]). Subgroup analyses indicated that cocaine users had a blunted ERN compared to controls (g = 1.12, 95%CI [0.77, 1.47]). There was limited evidence for publication/small study bias. Although the results indicate a potential dissociation between substance types, this meta‐analysis revealed the need for additional research on the RewP/ERN in substance using populations and for better designed experiments that adequately address research questions.

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Late positive potential as a candidate biomarker of motivational relevance in substance use: Evidence from a meta-analysis

Cited by 15 publications

References 92 publications

Physiological stress modulation of neural drug cue reactivity in cannabis use disorder.

Physiological stress modulation of neural drug cue reactivity in cannabis use disorder.

Physiological stress reactivity’s role in post-stress modulation of the drug cue-elicited late positive potential in Cannabis Use Disorder

A meta‐analysis of electrophysiological biomarkers of reward and error monitoring in substance misuse

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