Late paternity and stillbirth risk

Astolfi, Paola; Pasquale, Antonio De; Zonta, Laura Attinia

doi:10.1093/humrep/deh449

Cited by 40 publications

(30 citation statements)

References 39 publications

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“…We found that paternal age was an independent risk factor for adverse fetal birth outcomes, in which elevated risks for stillbirth and late stillbirth were observed for the older paternal age categories. These findings support the current hypothesis that in utero fetal development and survival are influenced by not only maternal but also paternal characteristics and is supported by previous research on paternal aging and stillbirth risk (Astolfi et al, 2004). Furthermore, the findings of this study are congruent with the notion of including fathers within the current framework of prenatal care and decision making, as well as counseling during the preconception period, to optimize pregnancy outcomes.…”

Section: Discussionsupporting

confidence: 90%

The Effect of Paternal Age on Fetal Birth Outcomes

et al. 2012

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Research investigating the role of paternal age in adverse birth outcomes is limited. This population-based retrospective cohort study used the Missouri maternally linked data set from 1989 to 2005 to assess whether paternal age affects fetal birth outcomes: low birth weight (LBW), preterm birth (PTB), stillbirth, and small size for gestational age (SGA). We examined these outcomes among infants across seven paternal age-groups (<20, 20-24, 25-29, 30-34, 35-39, 40-45, and >45 years) using the generalized estimating equation framework. Compared with infants born to younger fathers (25-29 years), infants born to fathers aged 40 to 45 years had a 24% increased risk of stillbirth but a reduced risk of SGA. A 48% increased risk of late stillbirth was observed in infants born to advanced paternal age (>45 years). Moreover, advanced paternal age (>45 years) was observed to result in a 19%, 13%, and 29% greater risk for LBW, PTB, and VPTB (very preterm birth) infants, respectively. Infants born to fathers aged 30 to 39 years had a lower risk of LBW, PTB, and SGA, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes. These findings demonstrate that paternal age influences birth outcomes and warrants further investigation.

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Section: Discussionsupporting

confidence: 90%

The Effect of Paternal Age on Fetal Birth Outcomes

et al. 2012

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“…In Spain registration of foetal deaths is required only in cases where the gestation is greater than 180 days. This threshold is comparable to the Italian ISTAT definition (Astolfi et al 2004). Huang et al (2008) suggested that, in the absence of pre-existing medical disorders, it is difficult to establish a range of limit points within a continuous variable, such as age.…”

Section: Introductionmentioning

confidence: 53%

Stillbirth incidence in Spain: A comparison of native and recent immigrant mothers

Fuster¹,

Zuluaga²,

Román-Busto³

2014

DemRes

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“…Growing evidence indicates that paternal aging is also a risk factor for congenital malformations and genetic disorders (Newcombe and Tavendale, 1965;Savitz et al, 1991;Crow, 2000;Zhu et al, 2008), which may be linked to accumulation of mutations in germ cells of aging parents, perhaps resulting from normal wear and tear as well as exposure to harmful environments over time (Savitz et al, 1991;Yauk et al, 2007;Malik et al, 2008). Moreover, child bearing at a later age is associated with adverse birth outcomes, such as preeclampsia, pre-term birth, stillbirth, low birthweight and child mortality; and predisposition of the offspring to serious health problems such as autism, epilepsy, schizophrenia and Alzheimer's disease (Fretts et al, 1995;Bertram et al, 1998;Abel et al, 2002;Harlap et al, 2002;Byrne et al, 2003;Astolfi et al, 2004Astolfi et al, , 2006Vestergaard et al, 2005;Durkin et al, 2008;Zhu et al, 2008). Advanced maternal age at childbirth has been linked to menstrual disorders and subfecundity in daughters owing to endocrinological irregularities (Smits et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Parental age at childbirth and age of menarche in the offspring

Shrestha¹,

Nøhr

Bech

et al. 2010

Human Reproduction

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background: Early age of menarche (AOM) is associated with serious health problems including breast cancer and heart disease.Rising parental age at childbirth is associated with some adverse health outcomes in the offspring, but whether early menarche is one of them is not known. methods:We studied a Danish cohort of singleton females (n ¼ 3168) born in [1984][1985][1986][1987]. Prenatal data were collected from mothers around 36th week of pregnancy (self-administered questionnaire), although the menarcheal age was collected from daughters aged 17 -21 years in 2005 (Web-based questionnaire). We assessed each parental age association in separate linear regression models adjusted for covariates (socioeconomic status, parity, maternal pre-pregnancy BMI, marital status, maternal smoking and daughter's self-reported BMI), then included both ages in a third model. conclusions: We found no significant association between parental age and AOM, but the small sample of advance aged parents (over 30 years) limits the information we have. Future studies with a larger sample or a sample with over-representation of older parents will be of value.

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Late paternity and stillbirth risk

Abstract: The effect of paternal ageing on stillbirth risk is revealed in mothers aged > or =30 years and is modified by family education. In mothers aged 30-34 years from families with high education, the increase imputable to paternal ageing might be indicative of a genetic component.

Cited by 40 publications

References 39 publications

The Effect of Paternal Age on Fetal Birth Outcomes

The Effect of Paternal Age on Fetal Birth Outcomes

Stillbirth incidence in Spain: A comparison of native and recent immigrant mothers

Parental age at childbirth and age of menarche in the offspring

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