Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity

Hamad, Abdualrahman E.; Moinuddin, Omar; Blair, Michael P.; Schechet, Sidney A.; Shapiro, Michael J.; Quiram, Polly A.; Mammo, Danny A.; Berrocal, Audina M.; Prakhunhungsit, Supalert; Cernichiaro-Espinosa, Linda A.; Mukai, Sonoyo; Yonekawa, Yoshihiro; Ung, Cindy; Holz, Eric R.; Harper, C. Armitage; Young, Ryan C.; Besirli, Cagri G.; Nagiel, Aaron; Lee, Thomas C.; Gupta, Mrinali P.; Walsh, Mark K.; Khawly, Joseph A.; Campbell, J. Peter; Kychenthal, Andrés; Nudleman, Eric; Robinson, Josh E.; Hartnett, M. Elizabeth; Calvo, Charles M.; Chang, Emmanuel

doi:10.1016/j.oret.2019.12.015

Cited by 53 publications

(62 citation statements)

References 28 publications

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“…Infants with untreated ROP have a wide range of vision outcomes, with no light perception as the worst-case scenario [ 55 ]. Even in those with treated ROP, approximately 4.1—30% will have visual impairment due to a variety of causes including refractive errors, amblyopia, strabismus, and retinal detachment [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Pheng

Lim

Tai

et al. 2021

IJERPH

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Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder attributed to an ischaemic stimulus in preterm infants. Haemoglobin, the main component for oxygen transportation, may be implicated in ROP development. This retrospective study compared the mean weekly haemoglobin levels between infants with and without ROP over the first six weeks of life. Premature infants of less than 32 weeks gestational age and less than 1.5 kg birth weight were grouped into age and birth weight-matched ROP cases and controls. Weekly mean haemoglobin levels were documented. An independent t-test was used to analyze the difference in mean haemoglobin levels between infants with ROP and infants without ROP. Adjustment for confounders was performed using one-way analysis of covariance. There was a statistically significant difference in adjusted mean haemoglobin levels between the ROP and non-ROP group during the first week of life (p = 0.038). No significant intergroup differences were observed at the other weeks. Haemoglobin monitoring during the first week of postnatal life may be useful to guide ROP screening in premature infants.

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Section: Discussionmentioning

confidence: 99%

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Pheng

Lim

Tai

et al. 2021

IJERPH

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“…4,7,13,15 Conversely, the occurrence of tractional retinoschisis without Coats exudation in late, untreated ROP has been reported by Hamad et al at an incidence of almost 12% of eyes. 16 In 2015, Gursoy and colleagues reported a case of advanced bilateral ROP with sequential bilateral Coats-like retinopathy without retinoschisis. 4 A combination of anti-VEGF, photocoagulation, and cryotherapy resulted in regression.…”

Section: Discussionmentioning

confidence: 99%

X-Linked Retinoschisis and a Coats-Like Response in the Setting of Retinopathy of Prematurity

Fan

McAllister

Yannuzzi

et al. 2020

Journal of VitreoRetinal Diseases

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Purpose: This case report describes a unique case of a young patient with retinopathy of prematurity (ROP), a unilateral Coats-like response, and X-linked retinoschisis (XLRS). Methods: A 9-year-old boy with a history of regressed ROP presented with a unilateral Coats-like response, subretinal exudation, and XLRS. Examination and imaging findings demonstrated a highly unique combination of bilateral retinoschisis and a dramatic unilateral Coats-like response with a large schisis cavity. Results: Treatment with laser photocoagulation and anti-VEGF therapy led to resolution of the subretinal exudative changes. Conclusions: This is the first published description to our knowledge of a patient with a Coats-like response, XLRS, and a history of regressed ROP with resolution after treatment.

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“…Of utmost importance, anti-VEGF therapy for ROP is far from the “one and done” paradigm, as there is an extremely high likelihood (>90%) of needing additional examination under anesthesia, fluorescein angiography, and laser treatment in both eyes following anti-VEGF treatment. In addition, there are lifelong anatomical changes in the peripheral retina and increased risk for retinal detachment as a young adult (especially if the child was not also treated with laser therapy) which requires life-long monitoring [ 43 ].…”

Section: Treatment: Anti-vascular Endothelial Growth Factor (Anti-vegf) Therapy For Type 1 Ropmentioning

confidence: 99%

“…The literature varies in describing this phenomenon, with one study finding that only 50% of the vasculature reached Zone III following IVR [ 59 ], and another study finding that only 3.3% of eyes following IVB fully vascularized (within 2 optic disc diameters of the termination of the retina) [ 60 ]. Persistent avascular retina increases the risk of ROP disease re-activation as well as retinal tears and detachments later in life [ 43 , 61 , 62 ]. In a large retrospective review of 363 eyes with untreated (mild or regressed) retinopathy of prematurity, 30.8% of eyes developed a retinal detachment [ 43 ].…”

Section: The Role Of Fluorescein Angiography and “Delayed” Lasermentioning

confidence: 99%

80 Years of vision: preventing blindness from retinopathy of prematurity

Wood

Chang

Beck³

et al. 2021

J Perinatol

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Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity

Cited by 53 publications

References 28 publications

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

X-Linked Retinoschisis and a Coats-Like Response in the Setting of Retinopathy of Prematurity

80 Years of vision: preventing blindness from retinopathy of prematurity

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