Late-onset pulmonary arterial hypertension after successful early arterial switch surgery for simple transposition of the great arteries

Pulmonary arterial hypertension (PAH) is a rare but severe complication that should be investigated in patients diagnosed with transposition of the great arteries who have undergone neonatal arterial switch operation. Early diagnosis and aggressive combination therapy for PAH could help to improve survival in these patients. We report a favorable clinical response 6 months after the initiation of vasodilator therapy in a pediatric case with transposition of the great arteries, successfully repaired in the neonatal period, who developed pulmonary arterial hypertension at the age of 5 years.

show abstract

“…18 Smedema et al described a young male patient who was diagnosed with severe PAH 14 years after neonatal ASO. 19…”

Section: Discussionmentioning

confidence: 99%

Critical Neonatal Congenital Heart Disease – a Rare Complication after Successful Surgical Correction

Şuteu¹,

Muntean

Blesneac³

et al. 2020

Journal of Cardiovascular Emergencies

View full text Add to dashboard Cite

show abstract

“…For every 10% increase in LGE the LVEDV increased 9.1 ml in volume (r 2 0.239, p < 0.001, 95% CI 5.27 ml -12.92 ml). In patients with sVT at presentation the median LVEF was significantly poorer, and LV mass, LVEDV index, and %LV LGE significantly higher when compared to those without sVT at presentation (respectively 60% [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] (p = 0.016)). Figures 1A and 1B illustrate the base-line findings and outcomes.…”

Section: Cmr Findingsmentioning

confidence: 99%

“…10 cardiac events 1 -SCD at 3 months -biventricular LGE, LV LGE 32% 1 -3 rd degree AVB/PM implantation at 6 months -no LGE 1 -admission for CCF at 15 months -LV LGE 35% 7 -appropriate ICD therapy for VT/VF at 1-80 months -4 biventricular LGE, LV LGE 21% [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Programmed Electrical Stimulation: 6/8 (75%) PES with inducible sustained VT had arrhythmic end-point -i.e.VT/VF 1/11 (9%) PES without inducible VT had arrhythmic end-point -sustained VT at 10 months -no LGE PPV of PES + for arrhythmic end point: 75%, NPV of PESfor arrhythmic end point 91%, PES + for sustained VT correlated with trans-mural LGE (p = 0.018), and impaired LVEF < 40% (p = 0.018), LVEF in PES + compared to PESrespectively 38% and 61% [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70], p = 0.012 RVEF in PES + compared to PES -respectively 47% [40][41][42][43][44][45][46][47][48][49][50]…”

Section: Introductionmentioning

confidence: 99%

Delayed-Enhanced Cardiovascular Magnetic Resonance in the diagnosis and management of Cardiac Sarcoidosis

Smedema¹

View full text Add to dashboard Cite

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

show abstract

Late-onset pulmonary arterial hypertension after successful early arterial switch surgery for simple transposition of the great arteries

Cited by 2 publications

References 30 publications

Critical Neonatal Congenital Heart Disease – a Rare Complication after Successful Surgical Correction

Critical Neonatal Congenital Heart Disease – a Rare Complication after Successful Surgical Correction

Delayed-Enhanced Cardiovascular Magnetic Resonance in the diagnosis and management of Cardiac Sarcoidosis

Contact Info

Product

Resources

About