Late-onset mitochondrial encephalopathy with lactic acidosis and stroke-like episodes and the role of serial imaging
Robert Ambrogetti,
Ethan Kavanagh,
Khalid ElTayeb
Abstract:Mitochondria are essential for human metabolic function. Over 350 genetic mutations are associated with mitochondrial diseases, which are inherited in a matrilineal fashion. In mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), defective mitochondrial function and resultant impaired cellular energy production compromise vascular perfusion in affected tissues. Early diagnostic criteria suggested the diagnosis should be considered in those under 40. However, a broader range of phe… Show more
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