Late-onset idiopathic thrombocytopenic purpura correlates with rapid B-cell recovery after allogeneic T-cell-depleted peripheral blood progenitor cell transplantation in children

Kałwak, K.; Gorczyńska, Ewa; Wójcik, Dorota; Toporski, Jacek; Turkiewicz, Dominik; Slociak, M; Latos-Grażyńska, Elżbieta; Bogusławska-Jaworska, J; Chybicka, Alicja

doi:10.1016/s0041-1345(02)03607-2

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…In addition to humoral immunity, multi-dysfunction of cellular immunity is considered etiologic in ITP. There is more than one dysfunctional step in the pathogenesis in ITP such as abnormalities of T-cells (the T helper 1, Th1) bias, the defective suppressive function of regulatory T-cells, and the platelet destruction by cytotoxic Tcells (CTLs), B-cells, costimulating factor, and altered cell communication [3][4][5][6][7][8][9]. The treatment regimens for ITP including glucocorticosteroids, intravenous IgG, anti-D, splenectomy, rituximab, and TPO receptor agonists are not always effective [8,10].…”

Section: Introductionmentioning

confidence: 99%

CD72 gene expression in immune thrombocytopenia

Zhou

et al. 2011

Platelets

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To explore the role of CD72 in the pathogenesis of immune thrombocytopenia (ITP), we detected CD72, Sema4D, IL-2, IL-4, and IFN-γ mRNA expressions and the levels of plasma Sema4D, IL-2, IL-4, IL-6, and IFN-γ in ITP patients (n = 39) and controls (n = 23). The levels of plasma IL-2, IL-4, and IL-6 were assayed by radioimmunoassay, and the levels of plasma IFN-γ and Sema4D were analyzed by enzyme-linked immunosorbent assay. Sema4D, CD72, IL-2, IFN-γ, and IL-4mRNA expressions were analyzed by real-time quantitative reverse-transcription polymerase chain reaction. The expression of CD72 mRNA in ITP patients (n = 23) with active disease was significantly lower than that in patients in remission (p = 0.029) (n = 16) and controls (p = 0.0296) (n = 23). The IFN-γ/IL-4 mRNA (Th1/Th2) expression in ITP patients with active disease and in remission was significantly higher than that in controls (p = 0.0023, p = 0.0125, respectively). The expression of IL-2 mRNA in ITP patients with active disease was significantly lower than that in patients in remission (p = 0.0418) and controls (p = 0.004). The level of plasma IL-2 in ITP patients with active disease was significantly lower than that in patients in remission (p = 0.0029) and controls (p = 0.0101). The levels of plasma IL-4 in ITP patients with active disease and in remission were significantly higher than that of controls (p = 0.0093, p = 0.0053, respectively). CD72 mRNA expression level might correlate with Sema4D mRNA expression in peripheral blood mononuclear cells and level of plasma IL-2 in active ITP patients (p = 0.024 and p = 0.036). Our findings suggest that CD72 might be involved in the pathophysiological process of the ITP disease by increasing B-cell receptor signals.

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Section: Introductionmentioning

confidence: 99%

CD72 gene expression in immune thrombocytopenia

Zhou

et al. 2011

Platelets

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“…In post-transplant microvariant nephrotic syndrome, real-time polymerase chain reaction (PCR) revealed that the onset of the disease was associated with an increase in tumor necrosis factor-α and interferon-γ produced by T cells ( 22 ), and it has been speculated that cytokines produced by activated T cells due to abnormal cellular immunity may be involved. In addition, since the incidence of autoimmune thrombocytopenic purpura after transplantation is frequently observed during the period of reduction or discontinuation of immunosuppressant drugs, the involvement of recovery of the donor-derived lymphocyte function, especially humoral immunity, has been speculated ( 23 ). Similarly, post-transplant myasthenia gravis has been reported to occur after the reduction or discontinuation of immunosuppressive drugs and has been characterized as being more common in patients with chronic GVHD than in those without.…”

Section: Discussionmentioning

confidence: 99%

Anti-MDA-5 Antibody-positive Dermatomyositis after Allogeneic Bone Marrow Transplantation for Acute Transformation of Chronic Myelogenous Leukemia

et al. 2023

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Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody-positive dermatomyositis is a disease with a poor prognosis associated with rapid progressive interstitial pneumonia. Autoimmune diseases have occasionally been reported to occur after hematopoietic stem cell transplantation (HSCT). We experienced a case of anti-MDA-5 antibody-positive dermatomyositis after HSCT. In this case, a sufficient dose of cyclophosphamide could not be administered due to an impaired bone marrow function. We discuss the complications of autoimmune diseases after HSCT.

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“…When there is dysregulation in the reconstitution of lymphocytes, there is loss of self-tolerance and proliferation of autoreactive lymphocytes [7,17]. Early recovery of B cells with delayed Treg development, especially after a severely T celledepleted allogeneic HSCT, could cause autoimmunity [18]. The lack of Tregs during the lymphodepleted phase can inhibit the mechanisms of tolerance with expansion of autoreactive B and T cells [19].…”

Section: Homeostatic Expansionmentioning

confidence: 99%

“…There is a reported case of adoptive transfer of donor ITP after allogeneic HSCT [48]. Rapid B cell recovery after T cell depletion with delay in Treg reconstitution has also been indicated [18,49].…”

Section: Autoimmune Thrombocytopeniamentioning

confidence: 99%

Immune-Mediated Complications after Hematopoietic Stem Cell Transplantation

Rubinstein

Thota

et al. 2016

Biology of Blood and Marrow Transplantation

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Hematopoietic stem cell transplantation (HSCT) has an integral role in the treatment of malignant and nonmalignant diseases. Long-term complications after HSCT have been well established and include graft-versus-host disease (GVHD), conditioning regimen-related toxicities, disease relapse, and infections. Immune-mediated phenomena are increasingly described after HSCT with clinically significant sequelae. Diagnosis is challenging because of features that overlap with other commonly reported post-transplantation complications. Patients who experience immune-mediated disease after HSCT tend to have poor outcomes. Early recognition of immune-mediated complications is imperative to reduce preventable morbidity and mortality. This review looks at the currently available literature on pathogenesis, incidence, risk factors, treatment, and outcomes of immune-mediated disease (other than GVHD) after HSCT.

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Late-onset idiopathic thrombocytopenic purpura correlates with rapid B-cell recovery after allogeneic T-cell-depleted peripheral blood progenitor cell transplantation in children

Cited by 11 publications

References 11 publications

CD72 gene expression in immune thrombocytopenia

CD72 gene expression in immune thrombocytopenia

Anti-MDA-5 Antibody-positive Dermatomyositis after Allogeneic Bone Marrow Transplantation for Acute Transformation of Chronic Myelogenous Leukemia

Immune-Mediated Complications after Hematopoietic Stem Cell Transplantation

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