Late onset Epstein–Barr virus-associated lymphoproliferative disease after allogeneic bone marrow transplant presenting as breast masses

Abhyankar, SH; Chiang, K-Y; Jp, McGuirk; Ar, Pati; Godder, K.; Ja, Welsh; nd, Waldron Rl; Jl, McElveen; Henslee‐Downey, P. Jean

doi:10.1038/sj.bmt.1701070

Cited by 17 publications

(9 citation statements)

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“…EBV captured interest as a possible breast cancer agent when Labrecque et al [24] reported its presence in breast tissue. Some previous studies have demonstrated a high incidence of male breast cancer in countries with a high incidence of EBV-associated lymphomas [25], identification of EBV in primary breast lymphomas [26], and morphological similarities between nasopharyngeal carcinoma and spinal cord carcinoma [27], supporting the idea of pursuing research into a potential association of EBV and breast cancer.…”

Section: Investigations Of Viral Etiology For Breast Cancermentioning

confidence: 88%

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

2018

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Background: Although the association of human papillomavirus (HPV) with many cancers is well established, the involvement of HPV in breast cancer remains controversial. The purpose of this study is to perform a comprehensive review of the results and methods used to demonstrate that HPV markers are present in human breast cancer, and how well these studies fulfil the criteria for proving the viral etiology of a cancer. Study Design: We conducted a search for molecular studies published until November 2016 that relate human breast cancer to HPV. Results: Forty-three original molecular studies were found, some of which compared cases to nonneoplastic controls. Some investigations did not identify HPV in mammary tissue, but others identified it with different frequencies of positivity, varying between 1.2 and 86%. In most case-control studies (21/24 studies), positivity in cases was found to be higher than in controls, but odds ratios and confidence intervals were not reported. Conclusion: The results are controversial. However, they arouse a great interest in the potential participation of HPV in breast carcinogenesis, but rather as an essential cause-effect participant, at least as a co-participant in some cases. The circumstance of HPV positivity in breast cancer can be criticized, but the elements that clearly demonstrate it in a number of cases are also relevant.

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Section: Investigations Of Viral Etiology For Breast Cancermentioning

confidence: 88%

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

2018

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“…15,16 When clinical suspicions of LPD were entertained, every effort was made to obtain a tissue biopsy for pathological confirmation of the diagnosis of EBV-LPD. Peripheral blood as well as biopsy tissue samples (whenever possible) were sent for flow cytometric analysis for the presence of abnormal cellular clonality.…”

Section: Diagnosis Of Ebv-lpdmentioning

confidence: 99%

Epstein–Barr virus-associated B cell lymphoproliferative disorder following mismatched related T cell-depleted bone marrow transplantation

Chiang

Hazlett²,

Godder

et al. 2001

Bone Marrow Transplant

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Summary: Epstein-Barr virus (EBV) is closely associated with the progressive and often fatal lymphoproliferative disorders (LPD) inBone marrow transplantation provides a life-saving therapy for a variety of hematologic and non-hematologic diseases. 1 In bone marrow transplant recipients, manipulation of the marrow graft, infection, graft-versus-host disease (GVHD), and/or usage of immunosuppressive agents all contribute to delay in immune reconstitution. The incidence of EBV-LPD has been reported to be between 5 and 39% in solid organ transplant recipients. 2-4 EBV-LPD following autologous BMT is rare, 5,6 and the incidence of EBV-LPD in HLA-identical sibling bone marrow transplants is generally less than 1%. 7 Recently, several reports 8-12 have identified risk factors in allogeneic transplants, which are associated with an increased incidence of EBV-LPD. These risk factors include HLA disparity, depletion of the donor marrow graft with T cell-specific monoclonal antibodies (MAb), use of antithymocyte globulin in vivo, and severe GVHD.Increasing numbers of BMT are being performed using alternative donors and manipulated grafts. There has not been much reported focus on the incidence of EBV-LPD on these high-risk patients group. We retrospectively examined EBV-LPD in a series of 318 patients who underwent partially mismatched related donor bone marrow transplants at the Division of Transplantation Medicine in the University of South Carolina. This study represents the largest series describing the incidence of EBV-LPD following PMRD bone marrow transplants with T cell-depleted grafts from a single institution. This descriptive report is focused on EBV-LPD clinical characteristics, relationship

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“…It is also well recognised that African Burkitt's lymphoma can target the breast [91][92][93]. It is likely that the morphological similarities between NPC and some lymphocyte-rich types of breast carcinoma, including the rare medullary type, stimulated several workers to hypothesise that EBV could be associated with breast carcinomas in Western societies.…”

Section: Epstein-barr Virusmentioning

confidence: 99%

A Viral Aetiology for Breast Cancer: Time to Re-Examine the Postulate

Mant

Hodgson²,

Hobday

et al. 2004

Intervirology

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Despite decades of research, no aetiologic factor(s) for human breast cancer has been identified and the search for a causal agent has all but been abandoned during the past thirty years. Over 60 years ago, it was demonstrated that breast tumours in mice are caused by an oncornavirus, murine mammary tumour virus (MMTV). Whilst many at that time postulated a similar virus might be the causative agent of human breast cancer, genetic evidence was difficult to obtain primarily because of the occurrence of endogenous human retrovirus (HER) sequences within the human genome that share extensive regions of nucleotide homology with MMTV. Recently, there has been a resurgence of interest in the possibility that a significant proportion of human breast cancers may be caused by viral infections. Two candidate viruses have been proposed, a human retroviral analogue of MMTV (which differs significantly in sequence and characteristics from HERs) and, the Epstein-Barr virus (γ-herpes virus). These two viruses have been reported to occur in up to 37 and 50% of breast cancer cases, respectively. Here we present the background to the infectious hypothesis for the aetiology of breast cancer and review recent findings.

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Late onset Epstein–Barr virus-associated lymphoproliferative disease after allogeneic bone marrow transplant presenting as breast masses

Cited by 17 publications

References 1 publication

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

Epstein–Barr virus-associated B cell lymphoproliferative disorder following mismatched related T cell-depleted bone marrow transplantation

A Viral Aetiology for Breast Cancer: Time to Re-Examine the Postulate

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