Late onset dysthymic disorder and major depression differ from early onset dysthymic disorder and major depression in elderly outpatients

Devanand, Davangere P.; Adorno, Elizabeth; Cheng, Jocelyn; Burt, Tal; Pelton, Gregory H.; Roose, Steven P.; Sackeïm, Harold A.

doi:10.1016/s0165-0327(02)00307-5

Cited by 61 publications

(31 citation statements)

References 48 publications

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“…Loss of weight was more prevalent in LOD. These results are in line with studies investigating dysthymia and double depression in older patients (Beekman et al, 2004;Devanand et al, 2004) while the differences in clinical depressive symptoms between EOD and LOD subjects are in part consistent with previous findings of increased depressive ideation in EOD (Conwell et al, 1989;Krishnan et al, 1995). Although other studies have not replicated this finding (Greenwald and Kramer-Ginsberg, 1988;Brodaty et al, 2001).…”

Section: Partner Losssupporting

confidence: 92%

Late‐life depression: the differences between early‐ and late‐onset illness in a community‐based sample

Janssen

Beekman

Comijs

et al. 2005

Int J Geriat Psychiatry

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In a community-based sample we did not detect clear differences in etiology and phenomenology between EOD and LOD. This discrepancy with reports from clinical samples could be due to selection bias in clinical studies. Consequently, all patients with late-life depression deserve a diagnostic work-up of both psychosocial and somatic risk factors and treatment interventions should be focused accordingly.

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Section: Partner Losssupporting

confidence: 92%

Late‐life depression: the differences between early‐ and late‐onset illness in a community‐based sample

Janssen

Beekman

Comijs

et al. 2005

Int J Geriat Psychiatry

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“…Recent results show that cognitive impairment can persist despite improvement of depressive symptoms [6, 7], particularly when the onset of depression occurs in late life [8]. Several studies [2, 9, 10] have suggested that late-onset depression (LOD) may be associated with more frequent (up to 60%) and rapid cognitive decline compared to age-matched controls [10].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Late-Onset Depression

Delaloye

Baudois²,

Bilbao³

et al. 2008

Eur Neurol

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Background: While cognitive dysfunction in late-onset depression (LOD) is common, the nature and determinants of this impairment are heterogeneous. It has been suggested that neuropsychological decrements in LOD patients might result from a deficit in processing resources. In order to address this issue, we analyzed processing resources in LOD to see if their decrease explains higher-level cognition (episodic memory and naming capacity) deficits. Methods: Measures of processing speed, working memory, inhibition, episodic memory and naming capacity were administered to 14 LOD inpatients and 14 controls. Results: The LOD patients performed significantly worse than the controls in all domains except for inhibition. Hierarchical regression analyses showed that naming capacity impairment was totally mediated by processing speed and working memory, whereas episodic memory dysfunction was only partially mediated by working memory. Conclusion: The reduction in certain processing resources (working memory, processing speed) in late-onset depressed patients appears to mediate impairments in episodic memory and naming capacity. However, episodic memory impairment cannot only be explained by processing resource decrement in LOD patients, suggesting that a primary episodic memory dysfunction is present in this condition.

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“…In any case the effect of age of onset must be continuous. Many previous studies did use 50 years, and Devanand et al [46] found fairly stable differences between LOD and EOD irrespective of whether age of onset cutoffs were set at 50 or 60 years. Some other studies have set the arbitrary division line even lower.…”

Section: Discussionmentioning

confidence: 99%

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

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Background: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. Method: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. Results: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. Conclusion: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression.

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Late onset dysthymic disorder and major depression differ from early onset dysthymic disorder and major depression in elderly outpatients

Cited by 61 publications

References 48 publications

Late‐life depression: the differences between early‐ and late‐onset illness in a community‐based sample

Late‐life depression: the differences between early‐ and late‐onset illness in a community‐based sample

Cognitive Impairment in Late-Onset Depression

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

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